FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2537306989> ?p ?o ?g. }

• W2537306989 endingPage "2244" @default.
• W2537306989 startingPage "2236" @default.
• W2537306989 abstract "Several receptor tyrosine kinases (RTKs) including EGFR, ALK, and MET have been identified as therapeutic targets in non-small cell lung cancer (NSCLC). Among the downstream pathways of RTKs, the MAPK pathway is particularly important for cancer cell proliferation, differentiation, and survival. In this study, the effects of MEK inhibitors (trametinib and PD0325901) in several NSCLC cell lines with driver gene alterations, especially RTK genes, were tested in vitro using an MTT assay, and a wide range of sensitivities was found. In particular, all the EGFR-mutated cell lines were resistant to MEK inhibitors, whereas all the MET-amplified cell lines were sensitive. A bioinformatics technique and western blot analyses showed that the PI3K/AKT pathway is more activated in EGFR-mutated NSCLC than in MET-amplified NSCLC, and a PI3K inhibitor enhanced the sensitivity to trametinib in the EGFR-mutated cell lines, suggesting that this pathway is associated with resistance to MEK inhibitors. Although the HCC827 cell line (EGFR mutation) was resistant to MEK inhibitors, the HCC827CNXR cell line, whose driver gene shifts from EGFR to MET, exhibited enhanced sensitivity to MEK inhibitors, indicating the biological importance of the MAPK pathway for MET-amplified NCSLC. Furthermore, a synergistic effect of crizotinib (a MET inhibitor) and trametinib was observed in MET-amplified NCLC cell lines. Our findings indicate that the MAPK pathway is biologically important for MET-amplified NSCLC and strongly encourage the development of combination therapy with a MET inhibitor and a MEK inhibitor against MET-amplified NSCLC." @default.
• W2537306989 created "2016-10-28" @default.
• W2537306989 creator A5002405384 @default.
• W2537306989 creator A5004282323 @default.
• W2537306989 creator A5005624969 @default.
• W2537306989 creator A5015524135 @default.
• W2537306989 creator A5016503174 @default.
• W2537306989 creator A5027938444 @default.
• W2537306989 creator A5033862426 @default.
• W2537306989 creator A5038101792 @default.
• W2537306989 creator A5051802514 @default.
• W2537306989 creator A5052265261 @default.
• W2537306989 creator A5054052615 @default.
• W2537306989 creator A5075697574 @default.
• W2537306989 creator A5081110935 @default.
• W2537306989 date "2016-10-17" @default.
• W2537306989 modified "2023-10-14" @default.
• W2537306989 title "MEK inhibitors against MET-amplified non-small cell lung cancer" @default.
• W2537306989 cites W1773455335 @default.
• W2537306989 cites W1981145667 @default.
• W2537306989 cites W1982987246 @default.
• W2537306989 cites W1989786382 @default.
• W2537306989 cites W1998971866 @default.
• W2537306989 cites W2004774286 @default.
• W2537306989 cites W2007118438 @default.
• W2537306989 cites W2009711329 @default.
• W2537306989 cites W2011826559 @default.
• W2537306989 cites W2020608820 @default.
• W2537306989 cites W2035845984 @default.
• W2537306989 cites W2041420833 @default.
• W2537306989 cites W2043696829 @default.
• W2537306989 cites W2044414123 @default.
• W2537306989 cites W2049315660 @default.
• W2537306989 cites W2052378862 @default.
• W2537306989 cites W2056837471 @default.
• W2537306989 cites W2069421644 @default.
• W2537306989 cites W2077224394 @default.
• W2537306989 cites W2086631242 @default.
• W2537306989 cites W2093613683 @default.
• W2537306989 cites W2121260558 @default.
• W2537306989 cites W2129360604 @default.
• W2537306989 cites W2132157071 @default.
• W2537306989 cites W2132657998 @default.
• W2537306989 cites W2139236349 @default.
• W2537306989 cites W2140126391 @default.
• W2537306989 cites W2160247920 @default.
• W2537306989 cites W2160725767 @default.
• W2537306989 cites W2161821474 @default.
• W2537306989 cites W2165708858 @default.
• W2537306989 cites W2166084034 @default.
• W2537306989 cites W2170552969 @default.
• W2537306989 cites W2180481128 @default.
• W2537306989 cites W2342364781 @default.
• W2537306989 cites W2439107762 @default.
• W2537306989 cites W2517665762 @default.
• W2537306989 doi "https://doi.org/10.3892/ijo.2016.3736" @default.
• W2537306989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5118002" @default.
• W2537306989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27748834" @default.
• W2537306989 hasPublicationYear "2016" @default.
• W2537306989 type Work @default.
• W2537306989 sameAs 2537306989 @default.
• W2537306989 citedByCount "19" @default.
• W2537306989 countsByYear W25373069892017 @default.
• W2537306989 countsByYear W25373069892018 @default.
• W2537306989 countsByYear W25373069892019 @default.
• W2537306989 countsByYear W25373069892021 @default.
• W2537306989 countsByYear W25373069892022 @default.
• W2537306989 crossrefType "journal-article" @default.
• W2537306989 hasAuthorship W2537306989A5002405384 @default.
• W2537306989 hasAuthorship W2537306989A5004282323 @default.
• W2537306989 hasAuthorship W2537306989A5005624969 @default.
• W2537306989 hasAuthorship W2537306989A5015524135 @default.
• W2537306989 hasAuthorship W2537306989A5016503174 @default.
• W2537306989 hasAuthorship W2537306989A5027938444 @default.
• W2537306989 hasAuthorship W2537306989A5033862426 @default.
• W2537306989 hasAuthorship W2537306989A5038101792 @default.
• W2537306989 hasAuthorship W2537306989A5051802514 @default.
• W2537306989 hasAuthorship W2537306989A5052265261 @default.
• W2537306989 hasAuthorship W2537306989A5054052615 @default.
• W2537306989 hasAuthorship W2537306989A5075697574 @default.
• W2537306989 hasAuthorship W2537306989A5081110935 @default.
• W2537306989 hasBestOaLocation W25373069891 @default.
• W2537306989 hasConcept C101544691 @default.
• W2537306989 hasConcept C121608353 @default.
• W2537306989 hasConcept C143998085 @default.
• W2537306989 hasConcept C184235292 @default.
• W2537306989 hasConcept C2776232967 @default.
• W2537306989 hasConcept C2776256026 @default.
• W2537306989 hasConcept C2777506169 @default.
• W2537306989 hasConcept C2778472372 @default.
• W2537306989 hasConcept C2779422266 @default.
• W2537306989 hasConcept C2779438470 @default.
• W2537306989 hasConcept C2781249067 @default.
• W2537306989 hasConcept C502942594 @default.
• W2537306989 hasConcept C54355233 @default.
• W2537306989 hasConcept C57074206 @default.
• W2537306989 hasConcept C62112901 @default.
• W2537306989 hasConcept C62478195 @default.

• next