FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2537339723> ?p ?o ?g. }

• W2537339723 endingPage "45" @default.
• W2537339723 startingPage "37" @default.
• W2537339723 abstract "The South African clawed frog, Xenopus laevis, has a strong history as a suitable model for environmental studies. Its embryos and transparent tadpoles are highly sensitive to the environment and their developmental processes are well described. It is also amenable for molecular studies. These characteristics enable its use for rapid identification and understanding of exposure-induced defects. To investigate the consequences of chemical exposure on aquatic animals, Xenopus laevis embryos and tadpoles were exposed to the biocide, methylisothiazolinone (MIT). Frog tadpoles exposed to MIT following tail amputation lost their natural regenerative ability. This inhibition of regeneration led to a failure to regrow tissues including the spinal cord, muscle, and notochord. This MIT-dependent regenerative defect is due to a failure to close the amputation wound. A wound healing assay revealed that while untreated embryos close their wounds within one day after injury, MIT-treated animals maintained open wounds that did not reduce in size and caused lethality. Concomitant exposure of MIT with chemicals containing thiol groups such as glutathione and N-acetyl cysteine restored normal wound healing and regeneration responses in tadpoles. Together these results indicate that exposure to MIT impairs developmental wound repair and tissue regeneration in Xenopus laevis. Thus, this study reveals new aspects of MIT activity and demonstrates that Xenopus laevis is a well-suited model for facilitating future research into chemical exposure effects on injury responses." @default.
• W2537339723 created "2016-10-28" @default.
• W2537339723 creator A5031098170 @default.
• W2537339723 creator A5035032743 @default.
• W2537339723 creator A5058542308 @default.
• W2537339723 creator A5065423984 @default.
• W2537339723 creator A5068134592 @default.
• W2537339723 creator A5087420169 @default.
• W2537339723 date "2016-12-01" @default.
• W2537339723 modified "2023-10-01" @default.
• W2537339723 title "Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration" @default.
• W2537339723 cites W1508175871 @default.
• W2537339723 cites W1721669572 @default.
• W2537339723 cites W1761291524 @default.
• W2537339723 cites W1964706304 @default.
• W2537339723 cites W1965296879 @default.
• W2537339723 cites W1966406774 @default.
• W2537339723 cites W1984941121 @default.
• W2537339723 cites W1997774898 @default.
• W2537339723 cites W2007165774 @default.
• W2537339723 cites W2021058162 @default.
• W2537339723 cites W2021204903 @default.
• W2537339723 cites W2025294279 @default.
• W2537339723 cites W2033267151 @default.
• W2537339723 cites W2035936653 @default.
• W2537339723 cites W2039344238 @default.
• W2537339723 cites W2044250657 @default.
• W2537339723 cites W2045236185 @default.
• W2537339723 cites W2051414725 @default.
• W2537339723 cites W2054826495 @default.
• W2537339723 cites W2059812718 @default.
• W2537339723 cites W2061563606 @default.
• W2537339723 cites W2062094940 @default.
• W2537339723 cites W2070908085 @default.
• W2537339723 cites W2071033492 @default.
• W2537339723 cites W2072412081 @default.
• W2537339723 cites W2072505153 @default.
• W2537339723 cites W2076535503 @default.
• W2537339723 cites W2077890747 @default.
• W2537339723 cites W2086262311 @default.
• W2537339723 cites W2093080528 @default.
• W2537339723 cites W2099489016 @default.
• W2537339723 cites W2104901773 @default.
• W2537339723 cites W2105715849 @default.
• W2537339723 cites W2107016440 @default.
• W2537339723 cites W2128043470 @default.
• W2537339723 cites W2139043462 @default.
• W2537339723 cites W2149224807 @default.
• W2537339723 cites W2151536861 @default.
• W2537339723 cites W2159063766 @default.
• W2537339723 cites W2171490829 @default.
• W2537339723 cites W2205761303 @default.
• W2537339723 cites W2245617550 @default.
• W2537339723 cites W2276212571 @default.
• W2537339723 cites W2330842740 @default.
• W2537339723 cites W2334317506 @default.
• W2537339723 cites W2335576529 @default.
• W2537339723 cites W2347095414 @default.
• W2537339723 cites W2468835156 @default.
• W2537339723 cites W2485024012 @default.
• W2537339723 cites W2516878077 @default.
• W2537339723 cites W4243450759 @default.
• W2537339723 doi "https://doi.org/10.1016/j.aquatox.2016.10.016" @default.
• W2537339723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27810491" @default.
• W2537339723 hasPublicationYear "2016" @default.
• W2537339723 type Work @default.
• W2537339723 sameAs 2537339723 @default.
• W2537339723 citedByCount "5" @default.
• W2537339723 countsByYear W25373397232017 @default.
• W2537339723 countsByYear W25373397232020 @default.
• W2537339723 countsByYear W25373397232022 @default.
• W2537339723 countsByYear W25373397232023 @default.
• W2537339723 crossrefType "journal-article" @default.
• W2537339723 hasAuthorship W2537339723A5031098170 @default.
• W2537339723 hasAuthorship W2537339723A5035032743 @default.
• W2537339723 hasAuthorship W2537339723A5058542308 @default.
• W2537339723 hasAuthorship W2537339723A5065423984 @default.
• W2537339723 hasAuthorship W2537339723A5068134592 @default.
• W2537339723 hasAuthorship W2537339723A5087420169 @default.
• W2537339723 hasConcept C104317684 @default.
• W2537339723 hasConcept C105702510 @default.
• W2537339723 hasConcept C16685009 @default.
• W2537339723 hasConcept C171056886 @default.
• W2537339723 hasConcept C196843134 @default.
• W2537339723 hasConcept C203014093 @default.
• W2537339723 hasConcept C2776133846 @default.
• W2537339723 hasConcept C2776718933 @default.
• W2537339723 hasConcept C2779535977 @default.
• W2537339723 hasConcept C2780269544 @default.
• W2537339723 hasConcept C55493867 @default.
• W2537339723 hasConcept C71924100 @default.
• W2537339723 hasConcept C86803240 @default.
• W2537339723 hasConcept C87073359 @default.
• W2537339723 hasConcept C95444343 @default.
• W2537339723 hasConceptScore W2537339723C104317684 @default.
• W2537339723 hasConceptScore W2537339723C105702510 @default.
• W2537339723 hasConceptScore W2537339723C16685009 @default.
• W2537339723 hasConceptScore W2537339723C171056886 @default.

• next