FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2537377493> ?p ?o ?g. }

• W2537377493 abstract "The aim of this article is to review the interplay between adenosine and mast cells in asthma. Adenosine is an endogenous nucleoside released from metabolically active cells and generated extracellularly via the degradation of released ATP. It is a potent biological mediator that modula- tes the activity of numerous cell types including platelets, neutrophils and mast cells via action at specific adenosine receptors (A1, A2a, A2b, A3). These receptors are expressed on mast cells but the exact pattern of receptor subtype expression depends on the source of the mast cells. Adeno- sine is also a potent bronchoconstricting agent and is sug- gested to contribute to the pathophysiology of asthma. Evi- dence is provided to suggest that the nucleoside exerts its influence on the asthmatic condition through its ability to modulate the release of mast cell derived mediators. How- ever, the mechanism of adenosine/mast cell interaction which contributes to asthma remains unclear. Progress in the area has been hampered by the heterogeneity of mast cell res- ponses and a lack of highly specific receptor agonists and antagonists. The expression of different adenosine receptor subtypes on mast cells is described. The final section of the review presents data to suggest that BAL mast cells may provide an accurate and relevant model for future investi- gations and together with the development of superior pharmacological tools, may aid the realisation of the thera- peutic potential of adenosine/mast cell interactions in asthma. In conclusion, the role of adenosine in asthma is clearly com- plex. A better understanding of the contribution of adenosine to the asthmatic condition may lead to novel therapeutic approaches in the treatment of the disease." @default.
• W2537377493 created "2016-10-28" @default.
• W2537377493 creator A5062234265 @default.
• W2537377493 creator A5088456234 @default.
• W2537377493 date "1999-01-01" @default.
• W2537377493 modified "2023-09-24" @default.
• W2537377493 title "Review Adenosine, mast cells and asthma" @default.
• W2537377493 cites W1490279270 @default.
• W2537377493 cites W1499343079 @default.
• W2537377493 cites W1529918408 @default.
• W2537377493 cites W1532247415 @default.
• W2537377493 cites W1535611266 @default.
• W2537377493 cites W1545295983 @default.
• W2537377493 cites W1547230308 @default.
• W2537377493 cites W1680232320 @default.
• W2537377493 cites W1924515390 @default.
• W2537377493 cites W1959276012 @default.
• W2537377493 cites W1966657000 @default.
• W2537377493 cites W1967696463 @default.
• W2537377493 cites W1971866218 @default.
• W2537377493 cites W1972133285 @default.
• W2537377493 cites W1972431403 @default.
• W2537377493 cites W1981193359 @default.
• W2537377493 cites W1986494697 @default.
• W2537377493 cites W1986732364 @default.
• W2537377493 cites W1992023928 @default.
• W2537377493 cites W1993671977 @default.
• W2537377493 cites W1995484947 @default.
• W2537377493 cites W1997018092 @default.
• W2537377493 cites W2002129459 @default.
• W2537377493 cites W2006756106 @default.
• W2537377493 cites W2007934886 @default.
• W2537377493 cites W2011222413 @default.
• W2537377493 cites W2015286189 @default.
• W2537377493 cites W2017008588 @default.
• W2537377493 cites W2028692843 @default.
• W2537377493 cites W2030882045 @default.
• W2537377493 cites W2034090982 @default.
• W2537377493 cites W2040168089 @default.
• W2537377493 cites W2042059384 @default.
• W2537377493 cites W2049632565 @default.
• W2537377493 cites W2049900497 @default.
• W2537377493 cites W2054906104 @default.
• W2537377493 cites W2055203846 @default.
• W2537377493 cites W2058559462 @default.
• W2537377493 cites W2059153581 @default.
• W2537377493 cites W2061193280 @default.
• W2537377493 cites W2070693311 @default.
• W2537377493 cites W2076380054 @default.
• W2537377493 cites W2077712485 @default.
• W2537377493 cites W2081592351 @default.
• W2537377493 cites W2084839593 @default.
• W2537377493 cites W2086616049 @default.
• W2537377493 cites W2092820463 @default.
• W2537377493 cites W2101535048 @default.
• W2537377493 cites W2103983530 @default.
• W2537377493 cites W2105752678 @default.
• W2537377493 cites W2116418941 @default.
• W2537377493 cites W2122666166 @default.
• W2537377493 cites W2130535220 @default.
• W2537377493 cites W2145698708 @default.
• W2537377493 cites W2152261567 @default.
• W2537377493 cites W2248420142 @default.
• W2537377493 cites W2270897439 @default.
• W2537377493 cites W2281172583 @default.
• W2537377493 cites W2409997024 @default.
• W2537377493 cites W2413566081 @default.
• W2537377493 cites W2413736153 @default.
• W2537377493 cites W2416560444 @default.
• W2537377493 cites W2429379154 @default.
• W2537377493 cites W2466347511 @default.
• W2537377493 cites W2621317696 @default.
• W2537377493 cites W2007358080 @default.
• W2537377493 hasPublicationYear "1999" @default.
• W2537377493 type Work @default.
• W2537377493 sameAs 2537377493 @default.
• W2537377493 citedByCount "0" @default.
• W2537377493 crossrefType "journal-article" @default.
• W2537377493 hasAuthorship W2537377493A5062234265 @default.
• W2537377493 hasAuthorship W2537377493A5088456234 @default.
• W2537377493 hasConcept C134018914 @default.
• W2537377493 hasConcept C170493617 @default.
• W2537377493 hasConcept C185592680 @default.
• W2537377493 hasConcept C203014093 @default.
• W2537377493 hasConcept C2776042228 @default.
• W2537377493 hasConcept C2776543447 @default.
• W2537377493 hasConcept C2776991684 @default.
• W2537377493 hasConcept C2778938600 @default.
• W2537377493 hasConcept C2779726688 @default.
• W2537377493 hasConcept C55493867 @default.
• W2537377493 hasConcept C67907053 @default.
• W2537377493 hasConcept C86803240 @default.
• W2537377493 hasConcept C95444343 @default.
• W2537377493 hasConcept C98274493 @default.
• W2537377493 hasConceptScore W2537377493C134018914 @default.
• W2537377493 hasConceptScore W2537377493C170493617 @default.
• W2537377493 hasConceptScore W2537377493C185592680 @default.
• W2537377493 hasConceptScore W2537377493C203014093 @default.
• W2537377493 hasConceptScore W2537377493C2776042228 @default.
• W2537377493 hasConceptScore W2537377493C2776543447 @default.

• next