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- W2537609570 abstract "Author(s): Barton, V; Armeson, K; Hampras, S; Ferris, LK; Visvanathan, K; Rollison, D; Alberg, AJ | Abstract: BackgroundSome reports suggest a history of keratinocyte carcinoma (KC) may be associated with increased mortality. The high prevalence of KC makes the possibility of associated subsequent mortality from other causes important from a clinical and public health perspective. However, the variable methods and findings of existing studies leave the overall significance of these results uncertain. To provide clarity, we conducted a systematic review to characterize the evidence on the associations of KC with: 1) all-cause mortality, 2) cancer-specific mortality, and 3) cancer survival.MethodsBibliographic databases were searched through February 2016. Studies were included if adequate data were provided to estimate mortality ratios in patients with- vs.-without KC. Data were abstracted from the studies that met inclusion criteria.ResultsFor all-cause mortality, a significant increased risk was observed for patients with a history of squamous cell carcinoma (SCC) (relative risk estimates (RR) 1.25 and 1.30), whereas no increased risk was observed for patients with a history of basal cell carcinoma (BCC) (RRs 0.96 and 0.97). In one study, cancer-specific mortality was increased for patients with a KC history (RR 1.28; 95% CI 1.22-1.34). With few exceptions, across multiple types of cancer BCC and SCC were consistently associated with poorer survival from second primary malignancies.ConclusionMultiple studies support an association between KC and fatal outcomes; the associations tend to be more potent for SCC than BCC. Additional investigation is needed to more precisely characterize these associations and elucidate potential underlying mechanisms." @default.
- W2537609570 created "2016-10-28" @default.
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- W2537609570 date "2016-01-01" @default.
- W2537609570 modified "2023-10-01" @default.
- W2537609570 title "Keratinocyte carcinoma and risk of all-cause and cancer-related mortality: A systematic review" @default.
- W2537609570 doi "https://doi.org/10.5070/d3229032550" @default.
- W2537609570 hasPublicationYear "2016" @default.
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