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- W2537767577 endingPage "478" @default.
- W2537767577 startingPage "456" @default.
- W2537767577 abstract "The biosynthesis of proteins entails a complex series of chemical reactions that transform the information stored in the nucleic acid sequence into a polypeptide chain that needs to properly fold and reach its functional location in or outside the cell. It is of no surprise that errors might occur that alter the polypeptide sequence leading to a non-functional proteins or that impede delivery of proteins at the appropriate site of activity. In order to minimize such mistakes and guarantee the synthesis of the correct amount and quality of the proteome, cells have developed folding, quality control, degradation and transport mechanisms that ensure and tightly regulate protein biogenesis. Genetic mutations, harsh environmental conditions or attack by pathogens can subvert the cellular quality control machineries and perturb cellular proteostasis leading to pathological conditions. This review summarizes basic concepts of the flow of information from DNA to folded and active proteins and to the variable fidelity (from incredibly high to quite sloppy) characterizing these processes. We will give particular emphasis on events that maintain or recover the homeostasis of the endoplasmic reticulum (ER), a major site of proteins synthesis and folding in eukaryotic cells. Finally, we will report on how cells can adapt to stressful conditions, how perturbation of ER homeostasis may result in diseases and how these can be treated." @default.
- W2537767577 created "2016-10-28" @default.
- W2537767577 creator A5012945125 @default.
- W2537767577 creator A5035366529 @default.
- W2537767577 creator A5074679087 @default.
- W2537767577 date "2016-01-01" @default.
- W2537767577 modified "2023-09-27" @default.
- W2537767577 title "Quality control mechanisms of protein biogenesis: proteostasis dies hard" @default.
- W2537767577 cites W1481795283 @default.
- W2537767577 cites W1522752776 @default.
- W2537767577 cites W1546139069 @default.
- W2537767577 cites W1547110853 @default.
- W2537767577 cites W1782287000 @default.
- W2537767577 cites W1797898354 @default.
- W2537767577 cites W1848978662 @default.
- W2537767577 cites W1894612901 @default.
- W2537767577 cites W1910229720 @default.
- W2537767577 cites W1969809368 @default.
- W2537767577 cites W1974854199 @default.
- W2537767577 cites W1976678081 @default.
- W2537767577 cites W1979573823 @default.
- W2537767577 cites W1980438612 @default.
- W2537767577 cites W1981170034 @default.
- W2537767577 cites W1985387528 @default.
- W2537767577 cites W1986304086 @default.
- W2537767577 cites W1987769185 @default.
- W2537767577 cites W1989125189 @default.
- W2537767577 cites W1989768108 @default.
- W2537767577 cites W1989821468 @default.
- W2537767577 cites W1990054050 @default.
- W2537767577 cites W1991103963 @default.
- W2537767577 cites W1991547131 @default.
- W2537767577 cites W1991736711 @default.
- W2537767577 cites W1992125357 @default.
- W2537767577 cites W1993413544 @default.
- W2537767577 cites W1994117065 @default.
- W2537767577 cites W1994772574 @default.
- W2537767577 cites W1997464771 @default.
- W2537767577 cites W1997500225 @default.
- W2537767577 cites W1997811592 @default.
- W2537767577 cites W1998767410 @default.
- W2537767577 cites W2000789682 @default.
- W2537767577 cites W2001150129 @default.
- W2537767577 cites W2001314904 @default.
- W2537767577 cites W2002364392 @default.
- W2537767577 cites W2005539608 @default.
- W2537767577 cites W2008744347 @default.
- W2537767577 cites W201050536 @default.
- W2537767577 cites W2013241878 @default.
- W2537767577 cites W2013947447 @default.
- W2537767577 cites W2015227829 @default.
- W2537767577 cites W2019577213 @default.
- W2537767577 cites W2021242983 @default.
- W2537767577 cites W2025356047 @default.
- W2537767577 cites W2025851491 @default.
- W2537767577 cites W2026357888 @default.
- W2537767577 cites W2027619670 @default.
- W2537767577 cites W2030009057 @default.
- W2537767577 cites W2030267305 @default.
- W2537767577 cites W2031269330 @default.
- W2537767577 cites W2032700869 @default.
- W2537767577 cites W2033164699 @default.
- W2537767577 cites W2036333455 @default.
- W2537767577 cites W2038287503 @default.
- W2537767577 cites W2040204840 @default.
- W2537767577 cites W2044353042 @default.
- W2537767577 cites W2045777307 @default.
- W2537767577 cites W2045893780 @default.
- W2537767577 cites W2046250764 @default.
- W2537767577 cites W2048281868 @default.
- W2537767577 cites W2048551040 @default.
- W2537767577 cites W2053442171 @default.
- W2537767577 cites W2055214702 @default.
- W2537767577 cites W2055347597 @default.
- W2537767577 cites W2055985881 @default.
- W2537767577 cites W2062717825 @default.
- W2537767577 cites W2063078491 @default.
- W2537767577 cites W2063240158 @default.
- W2537767577 cites W2070112408 @default.
- W2537767577 cites W2071849521 @default.
- W2537767577 cites W2077243151 @default.
- W2537767577 cites W2081104776 @default.
- W2537767577 cites W2082001606 @default.
- W2537767577 cites W2084944302 @default.
- W2537767577 cites W2085648696 @default.
- W2537767577 cites W2089273088 @default.
- W2537767577 cites W2089328676 @default.
- W2537767577 cites W2091303024 @default.
- W2537767577 cites W2092011356 @default.
- W2537767577 cites W2096261947 @default.
- W2537767577 cites W2097164847 @default.
- W2537767577 cites W2101445704 @default.
- W2537767577 cites W2102049218 @default.
- W2537767577 cites W2107493006 @default.
- W2537767577 cites W2111415532 @default.
- W2537767577 cites W2112137646 @default.
- W2537767577 cites W2114514257 @default.
- W2537767577 cites W2118934597 @default.