Matches in SemOpenAlex for { <https://semopenalex.org/work/W2537785526> ?p ?o ?g. }
- W2537785526 endingPage "117" @default.
- W2537785526 startingPage "110" @default.
- W2537785526 abstract "There is now growing evidence suggesting that Vitamin D is playing a critical role in modulating the innate and adaptive immune responses. Several polymorphisms have been identified in the vitamin D receptor (VDR) gene but their association with ulcerative colitis (UC) susceptibility remained controversy. In the current study, we examined the association between VDR polymorphisms and serum level of 25-hydroxyvitamin D [25(OH)D] with UC in Chinese Han population. Polymorphisms of FokI (rs2228570)/BsmI (rs1544410)/ApaI (rs7975232)/TaqI (rs731236) in the VDR gene were assessed in a case-control study comprising 404 UC patients and 612 controls. Moreover, 25(OH)D levels were measured by electro-chemiluminescence immunoassay in 75 UC patients and 120 controls. Our results suggested that BsmI polymorphism frequency was significantly lower in UC patients (P=0.028), and the frequency of AAC haplotype formed by BsmI, ApaI and TaqI was also significantly lower in UC patients (P=0.012). Moreover, FokI polymorphism was more frequently observed in patients with mild and moderate UC as compared to those with severe UC (P=0.001, P<0.001, respectively). Average 25(OH)D level was lower in UC patients than in controls (19.3±6.8 vs. 21.8±7.3ng/mL, P=0.017), and was significantly correlated with hemoglobin (β=0.49, P<0.001), C-reactive protein (β=-0.36, P<0.001), severity of UC (β=-0.21, P=0.025) and FokI polymorphism (β=-0.20, P=0.031) in UC patients. Interestingly, there was a significant correlation between FokI polymorphism and vitamin D deficiency (<20ng/mL) in UC patients (P=0.006). Together, these results supported that VDR polymorphisms and 25(OH)D level were significantly correlated with UC risk and severity in Chinese Han population." @default.
- W2537785526 created "2016-10-28" @default.
- W2537785526 creator A5010818881 @default.
- W2537785526 creator A5022496548 @default.
- W2537785526 creator A5028634125 @default.
- W2537785526 creator A5042921982 @default.
- W2537785526 creator A5055316584 @default.
- W2537785526 creator A5074270442 @default.
- W2537785526 creator A5088874330 @default.
- W2537785526 creator A5089488228 @default.
- W2537785526 date "2017-02-01" @default.
- W2537785526 modified "2023-10-12" @default.
- W2537785526 title "The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population" @default.
- W2537785526 cites W1501956704 @default.
- W2537785526 cites W1917017124 @default.
- W2537785526 cites W1956824670 @default.
- W2537785526 cites W1970956723 @default.
- W2537785526 cites W1986532444 @default.
- W2537785526 cites W1996562387 @default.
- W2537785526 cites W2009547297 @default.
- W2537785526 cites W2024513156 @default.
- W2537785526 cites W2027149883 @default.
- W2537785526 cites W2033023549 @default.
- W2537785526 cites W2033206630 @default.
- W2537785526 cites W2033459292 @default.
- W2537785526 cites W2046306450 @default.
- W2537785526 cites W2046600521 @default.
- W2537785526 cites W2067605997 @default.
- W2537785526 cites W2074596123 @default.
- W2537785526 cites W2075295377 @default.
- W2537785526 cites W2091134382 @default.
- W2537785526 cites W2091957879 @default.
- W2537785526 cites W2092185431 @default.
- W2537785526 cites W2094080536 @default.
- W2537785526 cites W2098442452 @default.
- W2537785526 cites W2102013054 @default.
- W2537785526 cites W2102354280 @default.
- W2537785526 cites W2109978145 @default.
- W2537785526 cites W2113143740 @default.
- W2537785526 cites W2116482730 @default.
- W2537785526 cites W2119092383 @default.
- W2537785526 cites W2133364349 @default.
- W2537785526 cites W2133540209 @default.
- W2537785526 cites W2134828080 @default.
- W2537785526 cites W2139890289 @default.
- W2537785526 cites W2145133165 @default.
- W2537785526 cites W2153059487 @default.
- W2537785526 cites W4210972027 @default.
- W2537785526 cites W4230739486 @default.
- W2537785526 doi "https://doi.org/10.1016/j.clinre.2016.09.001" @default.
- W2537785526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27771345" @default.
- W2537785526 hasPublicationYear "2017" @default.
- W2537785526 type Work @default.
- W2537785526 sameAs 2537785526 @default.
- W2537785526 citedByCount "12" @default.
- W2537785526 countsByYear W25377855262018 @default.
- W2537785526 countsByYear W25377855262019 @default.
- W2537785526 countsByYear W25377855262020 @default.
- W2537785526 countsByYear W25377855262022 @default.
- W2537785526 countsByYear W25377855262023 @default.
- W2537785526 crossrefType "journal-article" @default.
- W2537785526 hasAuthorship W2537785526A5010818881 @default.
- W2537785526 hasAuthorship W2537785526A5022496548 @default.
- W2537785526 hasAuthorship W2537785526A5028634125 @default.
- W2537785526 hasAuthorship W2537785526A5042921982 @default.
- W2537785526 hasAuthorship W2537785526A5055316584 @default.
- W2537785526 hasAuthorship W2537785526A5074270442 @default.
- W2537785526 hasAuthorship W2537785526A5088874330 @default.
- W2537785526 hasAuthorship W2537785526A5089488228 @default.
- W2537785526 hasConcept C104317684 @default.
- W2537785526 hasConcept C124490489 @default.
- W2537785526 hasConcept C126322002 @default.
- W2537785526 hasConcept C134018914 @default.
- W2537785526 hasConcept C135763542 @default.
- W2537785526 hasConcept C149737253 @default.
- W2537785526 hasConcept C179639408 @default.
- W2537785526 hasConcept C197754878 @default.
- W2537785526 hasConcept C203014093 @default.
- W2537785526 hasConcept C2779105492 @default.
- W2537785526 hasConcept C2779134260 @default.
- W2537785526 hasConcept C2780479503 @default.
- W2537785526 hasConcept C2781308329 @default.
- W2537785526 hasConcept C2908647359 @default.
- W2537785526 hasConcept C54355233 @default.
- W2537785526 hasConcept C71924100 @default.
- W2537785526 hasConcept C86803240 @default.
- W2537785526 hasConcept C90924648 @default.
- W2537785526 hasConcept C99454951 @default.
- W2537785526 hasConceptScore W2537785526C104317684 @default.
- W2537785526 hasConceptScore W2537785526C124490489 @default.
- W2537785526 hasConceptScore W2537785526C126322002 @default.
- W2537785526 hasConceptScore W2537785526C134018914 @default.
- W2537785526 hasConceptScore W2537785526C135763542 @default.
- W2537785526 hasConceptScore W2537785526C149737253 @default.
- W2537785526 hasConceptScore W2537785526C179639408 @default.
- W2537785526 hasConceptScore W2537785526C197754878 @default.
- W2537785526 hasConceptScore W2537785526C203014093 @default.
- W2537785526 hasConceptScore W2537785526C2779105492 @default.