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• W2537832546 endingPage "888" @default.
• W2537832546 startingPage "878" @default.
• W2537832546 abstract "In plants, RNA silencing regulates gene expression through the action of Dicer-like (DCL) and Argonaute (AGO) proteins via micro RNAs and RNA-dependent DNA methylation (RdDM). In addition, RNA silencing functions as an antiviral defense mechanism by targeting virus-derived double-stranded RNA. Plants encode multiple AGO proteins with specialized functions, including AGO4-like proteins that affect RdDM and AGO2, AGO5, and AGO1, which have antiviral activities. Here, we show that AGO4 is also required for defense against the potexvirus Plantago asiatica mosaic virus (PlAMV), most likely independent of RdDM components such as DCL3, Pol IV, and Pol V. Transient assays showed that AGO4 has direct antiviral activity on PlAMV and, unlike RdDM, this activity does not require nuclear localization of AGO4. Furthermore, although PlAMV infection causes a decrease in AGO4 expression, PlAMV causes a change in AGO4 localization from a largely nuclear to a largely cytoplasmic distribution. These results indicate an important role for AGO4 in targeting plant RNA viruses as well as demonstrating novel mechanisms of regulation of and by AGO4, independent of its canonical role in regulating gene expression by RdDM." @default.
• W2537832546 created "2016-10-28" @default.
• W2537832546 creator A5002351852 @default.
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• W2537832546 creator A5086027154 @default.
• W2537832546 date "2016-11-01" @default.
• W2537832546 modified "2023-10-14" @default.
• W2537832546 title "Antiviral Defense Involves AGO4 in an <i>Arabidopsis</i>–Potexvirus Interaction" @default.
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• W2537832546 doi "https://doi.org/10.1094/mpmi-09-16-0188-r" @default.
• W2537832546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27762650" @default.
• W2537832546 hasPublicationYear "2016" @default.

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