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• W2537958818 abstract "SUMMARY The aim of this study was to evaluate the effect of nerolidol free (N-F) and nerolidol-loaded in nanospheres (N-NS) on the hepatic antioxidant/oxidant status of mice experimentally infected by Trypanosoma evansi . In the liver it was measured: reactive oxygen species (ROS), thiobarbituric reactive acid substances (TBARS) and non-protein thiols (NPSH), catalase (CAT), superoxide dismutase (SOD) and glutathione-S-transferase (GST) and performed histopathological examination. In addition, seric levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured. Liver samples from mice infected by T. evansi showed increased ( P < 0·05) ROS, TBARS, AST and ALT levels and SOD activity, and decreased NPSH levels and CAT activity ( P < 0·05) compared with uninfected animals. N-NS treatment prevented ( P < 0·05) ROS and TBARS increase, and increased NPSH levels, and ameliorate CAT and SOD activities on liver of infected mice. Moreover, N-NS treatment reduced ( P < 0·05) AST and ALT levels, and prevented histopathological changes caused by the parasite. N-NS protected the liver from the oxidative stress caused by T. evansi , which might be due to its antioxidant properties. Nerolidol might be considered a promising therapeutic agent against oxidative stress, and nanotechnology is an encouraging approach to be explored." @default.
• W2537958818 created "2016-10-28" @default.
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• W2537958818 date "2016-10-17" @default.
• W2537958818 modified "2023-10-18" @default.
• W2537958818 title "Nerolidol-loaded nanospheres prevent hepatic oxidative stress of mice infected by<i>Trypanosoma evansi</i>" @default.
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• W2537958818 doi "https://doi.org/10.1017/s0031182016001803" @default.
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• W2537958818 hasPublicationYear "2016" @default.
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