Matches in SemOpenAlex for { <https://semopenalex.org/work/W2537974699> ?p ?o ?g. }
- W2537974699 endingPage "688" @default.
- W2537974699 startingPage "674" @default.
- W2537974699 abstract "Hu-antigen R (HuR) is an RNA-binding posttranscriptional regulator that belongs to the Hu/ELAV family. HuR expression levels are modulated by a variety of proteins, microRNAs, chemical compounds, or the microenvironment, and in turn, HuR affects mRNA stability and translation of various genes implicated in breast cancer formation, progression, metastasis, and treatment. The aim of the present review is to critically summarize the role of HuR in breast cancer development and its potential as a prognosticator and a therapeutic target. In this aspect, all the existing English literature concerning HuR expression and function in breast cancer cell lines, in vivo animal models, and clinical studies is critically presented and summarized. HuR modulates many genes implicated in biological processes crucial for breast cancer formation, growth, and metastasis, whereas the link between HuR and these processes has been demonstrated directly in vitro and in vivo. Additionally, clinical studies reveal that HuR is associated with more aggressive forms of breast cancer and is a putative prognosticator for patients' survival. All the above indicate HuR as a promising drug target for cancer therapy; nevertheless, additional studies are required to fully understand its potential and determine against which types of breast cancer and at which stage of the disease a therapeutic agent targeting HuR would be more effective." @default.
- W2537974699 created "2016-10-28" @default.
- W2537974699 creator A5004345445 @default.
- W2537974699 creator A5006412575 @default.
- W2537974699 creator A5056126637 @default.
- W2537974699 creator A5077465928 @default.
- W2537974699 date "2016-11-01" @default.
- W2537974699 modified "2023-09-26" @default.
- W2537974699 title "Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment" @default.
- W2537974699 cites W1492237306 @default.
- W2537974699 cites W1964170234 @default.
- W2537974699 cites W1965657782 @default.
- W2537974699 cites W1965882417 @default.
- W2537974699 cites W1967554461 @default.
- W2537974699 cites W1968242863 @default.
- W2537974699 cites W1971904680 @default.
- W2537974699 cites W1972056075 @default.
- W2537974699 cites W1973480874 @default.
- W2537974699 cites W1973614363 @default.
- W2537974699 cites W1976238769 @default.
- W2537974699 cites W1977629626 @default.
- W2537974699 cites W1977995106 @default.
- W2537974699 cites W1978947011 @default.
- W2537974699 cites W1981781176 @default.
- W2537974699 cites W1982476634 @default.
- W2537974699 cites W1982925662 @default.
- W2537974699 cites W1984485637 @default.
- W2537974699 cites W1988097332 @default.
- W2537974699 cites W1993691900 @default.
- W2537974699 cites W1993841930 @default.
- W2537974699 cites W1994121712 @default.
- W2537974699 cites W1995128552 @default.
- W2537974699 cites W2001320847 @default.
- W2537974699 cites W2001453032 @default.
- W2537974699 cites W2001724396 @default.
- W2537974699 cites W2003478746 @default.
- W2537974699 cites W2004851542 @default.
- W2537974699 cites W2005558505 @default.
- W2537974699 cites W2009012471 @default.
- W2537974699 cites W2012112428 @default.
- W2537974699 cites W2013331123 @default.
- W2537974699 cites W2014177782 @default.
- W2537974699 cites W2014548387 @default.
- W2537974699 cites W2014708467 @default.
- W2537974699 cites W2019563964 @default.
- W2537974699 cites W2019928317 @default.
- W2537974699 cites W2020081155 @default.
- W2537974699 cites W2029790299 @default.
- W2537974699 cites W2030248691 @default.
- W2537974699 cites W2032863945 @default.
- W2537974699 cites W2035142776 @default.
- W2537974699 cites W2037009541 @default.
- W2537974699 cites W2038162228 @default.
- W2537974699 cites W2039971642 @default.
- W2537974699 cites W2045632759 @default.
- W2537974699 cites W2046100110 @default.
- W2537974699 cites W2047667717 @default.
- W2537974699 cites W2049462796 @default.
- W2537974699 cites W2050489269 @default.
- W2537974699 cites W2055855613 @default.
- W2537974699 cites W2057961158 @default.
- W2537974699 cites W2058691182 @default.
- W2537974699 cites W2059646461 @default.
- W2537974699 cites W2059796196 @default.
- W2537974699 cites W2060708740 @default.
- W2537974699 cites W2062233672 @default.
- W2537974699 cites W2063091067 @default.
- W2537974699 cites W2069994852 @default.
- W2537974699 cites W2072622898 @default.
- W2537974699 cites W2073971623 @default.
- W2537974699 cites W2077091701 @default.
- W2537974699 cites W2079394315 @default.
- W2537974699 cites W2083131367 @default.
- W2537974699 cites W2087702912 @default.
- W2537974699 cites W2088590657 @default.
- W2537974699 cites W2090001497 @default.
- W2537974699 cites W2090009109 @default.
- W2537974699 cites W2091005985 @default.
- W2537974699 cites W2092165028 @default.
- W2537974699 cites W2093565522 @default.
- W2537974699 cites W2096259566 @default.
- W2537974699 cites W2097105411 @default.
- W2537974699 cites W2097789360 @default.
- W2537974699 cites W2098180928 @default.
- W2537974699 cites W2099518931 @default.
- W2537974699 cites W2100798473 @default.
- W2537974699 cites W2100835711 @default.
- W2537974699 cites W2101228135 @default.
- W2537974699 cites W2103374010 @default.
- W2537974699 cites W2104119190 @default.
- W2537974699 cites W2106135159 @default.
- W2537974699 cites W2108090987 @default.
- W2537974699 cites W2110062940 @default.
- W2537974699 cites W2111369086 @default.
- W2537974699 cites W2111685937 @default.
- W2537974699 cites W2113704334 @default.
- W2537974699 cites W2114160973 @default.
- W2537974699 cites W2115794627 @default.