Matches in SemOpenAlex for { <https://semopenalex.org/work/W2538025626> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2538025626 endingPage "539" @default.
- W2538025626 startingPage "533" @default.
- W2538025626 abstract "To ascertain efficacy and tolerability of carbamazepine (CBZ), sodium valproate (VPA), lamotrigine (LTG) and levetiracetam (LEV) using the UKAED register (www.ukaed.info).Patients on CBZ (n=91), VPA (n=61), LTG (n=105), LEV (n=72) and healthy control subjects (CTR) on no medication (n=51) were extracted. All patients had anonymously provided information on seizure type and frequency and completed the Liverpool Adverse Event Profile (LAEP).The number of seizure-free patients in the last 4 weeks was overall CBZ/VPA/LTG/LEV=60%/79%/67%/67%, for generalized epilepsy was CBZ/VPA/LTG/LEV=67%/89%/65%/94%, and for localization-related epilepsy was CBZ/VPA/LTG/LEV=59%/71%/67%/57%. Mean LAEP scores were CBZ/VPA/LTG/LEV/CTR=42.21/39.66/39.86/43.01/29.69. The mean LAEP was significantly higher in patients reporting depression and in patients with active epilepsy than in patients without depression and remission. Central nervous system (CNS) adverse effects including memory problems, difficulty concentrating, depression, unsteadiness, restlessness, feelings of anger, shaky hands and dizziness were significantly more frequent in CBZ, VPA, LTG and LEV than in CTR. The feeling of anger was significantly more frequent in LEV, and depression was significantly more frequent in CBZ compared to the other drugs.In this Internet-based register of self-reported efficacy and tolerability, CBZ, VPA, LTG and LEV were similar. Self-reported CNS adverse effects were significantly more frequent than in controls. In addition, anger was associated with LEV and depression with CBZ. Confounding factors were depression and uncontrolled epilepsy." @default.
- W2538025626 created "2016-10-28" @default.
- W2538025626 creator A5005845056 @default.
- W2538025626 creator A5038003929 @default.
- W2538025626 date "2016-10-18" @default.
- W2538025626 modified "2023-09-26" @default.
- W2538025626 title "Efficacy and tolerability of anti-epileptic drugs-an internet study" @default.
- W2538025626 cites W1603700769 @default.
- W2538025626 cites W1979819746 @default.
- W2538025626 cites W1982025098 @default.
- W2538025626 cites W1989268538 @default.
- W2538025626 cites W1996310014 @default.
- W2538025626 cites W2017924471 @default.
- W2538025626 cites W2027655456 @default.
- W2538025626 cites W2028500192 @default.
- W2538025626 cites W2034532029 @default.
- W2538025626 cites W2038469099 @default.
- W2538025626 cites W2054260662 @default.
- W2538025626 cites W2090551991 @default.
- W2538025626 cites W2090986994 @default.
- W2538025626 cites W2122924429 @default.
- W2538025626 cites W2126317054 @default.
- W2538025626 cites W2132499662 @default.
- W2538025626 cites W2138521331 @default.
- W2538025626 cites W2147519862 @default.
- W2538025626 cites W2147974822 @default.
- W2538025626 cites W2155517463 @default.
- W2538025626 cites W2169605702 @default.
- W2538025626 cites W2200287734 @default.
- W2538025626 cites W428228508 @default.
- W2538025626 doi "https://doi.org/10.1111/ane.12698" @default.
- W2538025626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27757951" @default.
- W2538025626 hasPublicationYear "2016" @default.
- W2538025626 type Work @default.
- W2538025626 sameAs 2538025626 @default.
- W2538025626 citedByCount "10" @default.
- W2538025626 countsByYear W25380256262017 @default.
- W2538025626 countsByYear W25380256262018 @default.
- W2538025626 countsByYear W25380256262019 @default.
- W2538025626 countsByYear W25380256262020 @default.
- W2538025626 countsByYear W25380256262021 @default.
- W2538025626 crossrefType "journal-article" @default.
- W2538025626 hasAuthorship W2538025626A5005845056 @default.
- W2538025626 hasAuthorship W2538025626A5038003929 @default.
- W2538025626 hasBestOaLocation W25380256261 @default.
- W2538025626 hasConcept C118552586 @default.
- W2538025626 hasConcept C126322002 @default.
- W2538025626 hasConcept C139719470 @default.
- W2538025626 hasConcept C162324750 @default.
- W2538025626 hasConcept C197934379 @default.
- W2538025626 hasConcept C2776867660 @default.
- W2538025626 hasConcept C2777332695 @default.
- W2538025626 hasConcept C2778186239 @default.
- W2538025626 hasConcept C2778375690 @default.
- W2538025626 hasConcept C2778802184 @default.
- W2538025626 hasConcept C2779253243 @default.
- W2538025626 hasConcept C71924100 @default.
- W2538025626 hasConcept C98274493 @default.
- W2538025626 hasConceptScore W2538025626C118552586 @default.
- W2538025626 hasConceptScore W2538025626C126322002 @default.
- W2538025626 hasConceptScore W2538025626C139719470 @default.
- W2538025626 hasConceptScore W2538025626C162324750 @default.
- W2538025626 hasConceptScore W2538025626C197934379 @default.
- W2538025626 hasConceptScore W2538025626C2776867660 @default.
- W2538025626 hasConceptScore W2538025626C2777332695 @default.
- W2538025626 hasConceptScore W2538025626C2778186239 @default.
- W2538025626 hasConceptScore W2538025626C2778375690 @default.
- W2538025626 hasConceptScore W2538025626C2778802184 @default.
- W2538025626 hasConceptScore W2538025626C2779253243 @default.
- W2538025626 hasConceptScore W2538025626C71924100 @default.
- W2538025626 hasConceptScore W2538025626C98274493 @default.
- W2538025626 hasIssue "5" @default.
- W2538025626 hasLocation W25380256261 @default.
- W2538025626 hasLocation W25380256262 @default.
- W2538025626 hasOpenAccess W2538025626 @default.
- W2538025626 hasPrimaryLocation W25380256261 @default.
- W2538025626 hasRelatedWork W2018889851 @default.
- W2538025626 hasRelatedWork W2070762175 @default.
- W2538025626 hasRelatedWork W2426802198 @default.
- W2538025626 hasRelatedWork W2565914894 @default.
- W2538025626 hasRelatedWork W2800793743 @default.
- W2538025626 hasRelatedWork W3008396421 @default.
- W2538025626 hasRelatedWork W3038019569 @default.
- W2538025626 hasRelatedWork W3120211463 @default.
- W2538025626 hasRelatedWork W4214613679 @default.
- W2538025626 hasRelatedWork W4235800070 @default.
- W2538025626 hasVolume "135" @default.
- W2538025626 isParatext "false" @default.
- W2538025626 isRetracted "false" @default.
- W2538025626 magId "2538025626" @default.
- W2538025626 workType "article" @default.