FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2538410523> ?p ?o ?g. }

• W2538410523 endingPage "668" @default.
• W2538410523 startingPage "663" @default.
• W2538410523 abstract "Aged garlic extract (AGE) is a popular nutritional supplement and is believed to promote health benefits by exhibiting antioxidant and anti-inflammatory activities and hypolipidemic and antiplatelet effects. We have previously identified N-α-(1-deoxy-d-fructos-1-yl)-l-arginine (FruArg) as a major contributor to the bioactivity of AGE in BV-2 microglial cells whereby it exerted a significant ability to attenuate lipopolysaccharide-induced neuroinflammatory responses and to regulate the Nrf2-mediated antioxidant response. Here, we report on a sensitive ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) protocol that was validated for the quantitation of FruArg in mouse plasma and brain tissue samples. Solid-phase extraction was used to separate FruArg from proteins and phospholipids present in the biological fluids. Results indicated that FruArg was readily absorbed into the blood circulation of mice after intraperitoneal injections. FruArg was reliably detected in the subregions of the brain tissue postinjection, indicating that it penetrates the blood-brain barrier in subnanomolar concentrations that are sufficient for its biological activity." @default.
• W2538410523 created "2016-10-28" @default.
• W2538410523 creator A5003965621 @default.
• W2538410523 creator A5025375830 @default.
• W2538410523 creator A5029138795 @default.
• W2538410523 creator A5062429074 @default.
• W2538410523 creator A5066396102 @default.
• W2538410523 creator A5079825099 @default.
• W2538410523 date "2016-10-25" @default.
• W2538410523 modified "2023-09-28" @default.
• W2538410523 title "Development of a Method and Validation for the Quantitation of FruArg in Mice Plasma and Brain Tissue Using UPLC–MS/MS" @default.
• W2538410523 cites W1548389490 @default.
• W2538410523 cites W1873363109 @default.
• W2538410523 cites W1907341342 @default.
• W2538410523 cites W1940376237 @default.
• W2538410523 cites W1943303117 @default.
• W2538410523 cites W1962566950 @default.
• W2538410523 cites W1972611314 @default.
• W2538410523 cites W1973544766 @default.
• W2538410523 cites W1983117952 @default.
• W2538410523 cites W1987785923 @default.
• W2538410523 cites W1989355099 @default.
• W2538410523 cites W2005423454 @default.
• W2538410523 cites W2006967871 @default.
• W2538410523 cites W2009878632 @default.
• W2538410523 cites W2015541518 @default.
• W2538410523 cites W2027250924 @default.
• W2538410523 cites W2027683710 @default.
• W2538410523 cites W2029695201 @default.
• W2538410523 cites W2032866414 @default.
• W2538410523 cites W2037517746 @default.
• W2538410523 cites W2053595255 @default.
• W2538410523 cites W2055041586 @default.
• W2538410523 cites W2058143878 @default.
• W2538410523 cites W2058164136 @default.
• W2538410523 cites W2059775744 @default.
• W2538410523 cites W2066372627 @default.
• W2538410523 cites W2067109836 @default.
• W2538410523 cites W2077216169 @default.
• W2538410523 cites W2099794801 @default.
• W2538410523 cites W2101099825 @default.
• W2538410523 cites W2103854085 @default.
• W2538410523 cites W2122219012 @default.
• W2538410523 cites W2135123400 @default.
• W2538410523 cites W2136157827 @default.
• W2538410523 cites W2136360772 @default.
• W2538410523 cites W2155717658 @default.
• W2538410523 cites W2324245696 @default.
• W2538410523 cites W2330405479 @default.
• W2538410523 cites W2408575276 @default.
• W2538410523 doi "https://doi.org/10.1021/acsomega.6b00220" @default.
• W2538410523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5088453" @default.
• W2538410523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27819064" @default.
• W2538410523 hasPublicationYear "2016" @default.
• W2538410523 type Work @default.
• W2538410523 sameAs 2538410523 @default.
• W2538410523 citedByCount "5" @default.
• W2538410523 countsByYear W25384105232018 @default.
• W2538410523 countsByYear W25384105232019 @default.
• W2538410523 crossrefType "journal-article" @default.
• W2538410523 hasAuthorship W2538410523A5003965621 @default.
• W2538410523 hasAuthorship W2538410523A5025375830 @default.
• W2538410523 hasAuthorship W2538410523A5029138795 @default.
• W2538410523 hasAuthorship W2538410523A5062429074 @default.
• W2538410523 hasAuthorship W2538410523A5066396102 @default.
• W2538410523 hasAuthorship W2538410523A5079825099 @default.
• W2538410523 hasBestOaLocation W25384105231 @default.
• W2538410523 hasConcept C126322002 @default.
• W2538410523 hasConcept C162356407 @default.
• W2538410523 hasConcept C179998833 @default.
• W2538410523 hasConcept C185592680 @default.
• W2538410523 hasConcept C203014093 @default.
• W2538410523 hasConcept C2778004101 @default.
• W2538410523 hasConcept C2778754761 @default.
• W2538410523 hasConcept C2986936838 @default.
• W2538410523 hasConcept C31827203 @default.
• W2538410523 hasConcept C43617362 @default.
• W2538410523 hasConcept C55493867 @default.
• W2538410523 hasConcept C64489805 @default.
• W2538410523 hasConcept C71924100 @default.
• W2538410523 hasConcept C86803240 @default.
• W2538410523 hasConcept C98274493 @default.
• W2538410523 hasConceptScore W2538410523C126322002 @default.
• W2538410523 hasConceptScore W2538410523C162356407 @default.
• W2538410523 hasConceptScore W2538410523C179998833 @default.
• W2538410523 hasConceptScore W2538410523C185592680 @default.
• W2538410523 hasConceptScore W2538410523C203014093 @default.
• W2538410523 hasConceptScore W2538410523C2778004101 @default.
• W2538410523 hasConceptScore W2538410523C2778754761 @default.
• W2538410523 hasConceptScore W2538410523C2986936838 @default.
• W2538410523 hasConceptScore W2538410523C31827203 @default.
• W2538410523 hasConceptScore W2538410523C43617362 @default.
• W2538410523 hasConceptScore W2538410523C55493867 @default.
• W2538410523 hasConceptScore W2538410523C64489805 @default.
• W2538410523 hasConceptScore W2538410523C71924100 @default.
• W2538410523 hasConceptScore W2538410523C86803240 @default.
• W2538410523 hasConceptScore W2538410523C98274493 @default.
• W2538410523 hasFunder F4320306096 @default.

• next