Matches in SemOpenAlex for { <https://semopenalex.org/work/W2538629088> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2538629088 abstract "FINGER is a multicenter randomized controlled trial (NCT01041989) that reported beneficial effects on cognition for a 2-year multimodal intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This study reports exploratory analyses of diffusion tensor imaging. FINGER targeted 1260 at-risk elderly from the general Finnish population, aged 60-77 years and without dementia/substantial cognitive impairment. Primary outcome was change in cognition (Neuropsychological Test battery, z-score). 60 cases (26 control, 34 intervention) who underwent baseline and 2-year followup MRI exams were selected from FINGER. Fractional anisotropy (FA) change and its correlation with cognitive change were analyzed using Tract-Based Spatial Statistics (TBSS). The total composite z-score and scores of memory, processing speed, and executive function domains showed significantly improved in the intervention group (p≤0.047), but no significant change in the control group (p≥0.061). Significant FA reduction was found in both groups (corrected for multiple comparisons, p<0.05). In the control group the FA reduction localized at genu of corpus callosum (CC). In the intervention group, the FA reduction localized at CC, bilateral posterior cingulum, frontal and cerebellar white matter (WM), left corticospinal track, fornix, and occipital and parietal WM, external capsule, superior and inferior longitudinal fasciculuses, right postcentral gyral WM. In the control group the FA reduction positively correlated with decrease of the total composite z-score at CC genu and right frontal, and also positively correlated with memory and executive function at CC body and genu, bilateral frontal, right external capsule, corticospinal track, cingulum, parietal WM, and superior longitudinal fasciculus (corrected, p<0.05) However, no any correlation was found in the intervention group. The 2-year multimodal intervention can change the evolution of WM. Considering the fact that FA change correlated with change in cognition in the control group but not in the intervention group, the reduction of FA in the two groups might involve different mechanisms." @default.
- W2538629088 created "2016-10-28" @default.
- W2538629088 creator A5006418280 @default.
- W2538629088 creator A5009884101 @default.
- W2538629088 creator A5026262571 @default.
- W2538629088 creator A5028144162 @default.
- W2538629088 creator A5034334081 @default.
- W2538629088 creator A5035161646 @default.
- W2538629088 creator A5042748010 @default.
- W2538629088 creator A5075861989 @default.
- W2538629088 creator A5079237983 @default.
- W2538629088 creator A5079862221 @default.
- W2538629088 creator A5086456642 @default.
- W2538629088 creator A5087888043 @default.
- W2538629088 date "2016-07-01" @default.
- W2538629088 modified "2023-10-02" @default.
- W2538629088 title "P3-030: White Matter Changes on Diffusion Tensor Imaging in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)" @default.
- W2538629088 doi "https://doi.org/10.1016/j.jalz.2016.06.1687" @default.
- W2538629088 hasPublicationYear "2016" @default.
- W2538629088 type Work @default.
- W2538629088 sameAs 2538629088 @default.
- W2538629088 citedByCount "0" @default.
- W2538629088 crossrefType "journal-article" @default.
- W2538629088 hasAuthorship W2538629088A5006418280 @default.
- W2538629088 hasAuthorship W2538629088A5009884101 @default.
- W2538629088 hasAuthorship W2538629088A5026262571 @default.
- W2538629088 hasAuthorship W2538629088A5028144162 @default.
- W2538629088 hasAuthorship W2538629088A5034334081 @default.
- W2538629088 hasAuthorship W2538629088A5035161646 @default.
- W2538629088 hasAuthorship W2538629088A5042748010 @default.
- W2538629088 hasAuthorship W2538629088A5075861989 @default.
- W2538629088 hasAuthorship W2538629088A5079237983 @default.
- W2538629088 hasAuthorship W2538629088A5079862221 @default.
- W2538629088 hasAuthorship W2538629088A5086456642 @default.
- W2538629088 hasAuthorship W2538629088A5087888043 @default.
- W2538629088 hasConcept C118552586 @default.
- W2538629088 hasConcept C126322002 @default.
- W2538629088 hasConcept C126838900 @default.
- W2538629088 hasConcept C142724271 @default.
- W2538629088 hasConcept C143409427 @default.
- W2538629088 hasConcept C149550507 @default.
- W2538629088 hasConcept C15744967 @default.
- W2538629088 hasConcept C169900460 @default.
- W2538629088 hasConcept C1862650 @default.
- W2538629088 hasConcept C2775968953 @default.
- W2538629088 hasConcept C2777193593 @default.
- W2538629088 hasConcept C2777796809 @default.
- W2538629088 hasConcept C2778183499 @default.
- W2538629088 hasConcept C2778677889 @default.
- W2538629088 hasConcept C2781161787 @default.
- W2538629088 hasConcept C2781192897 @default.
- W2538629088 hasConcept C2908647359 @default.
- W2538629088 hasConcept C548259974 @default.
- W2538629088 hasConcept C71924100 @default.
- W2538629088 hasConcept C89916169 @default.
- W2538629088 hasConcept C99454951 @default.
- W2538629088 hasConcept C99508421 @default.
- W2538629088 hasConceptScore W2538629088C118552586 @default.
- W2538629088 hasConceptScore W2538629088C126322002 @default.
- W2538629088 hasConceptScore W2538629088C126838900 @default.
- W2538629088 hasConceptScore W2538629088C142724271 @default.
- W2538629088 hasConceptScore W2538629088C143409427 @default.
- W2538629088 hasConceptScore W2538629088C149550507 @default.
- W2538629088 hasConceptScore W2538629088C15744967 @default.
- W2538629088 hasConceptScore W2538629088C169900460 @default.
- W2538629088 hasConceptScore W2538629088C1862650 @default.
- W2538629088 hasConceptScore W2538629088C2775968953 @default.
- W2538629088 hasConceptScore W2538629088C2777193593 @default.
- W2538629088 hasConceptScore W2538629088C2777796809 @default.
- W2538629088 hasConceptScore W2538629088C2778183499 @default.
- W2538629088 hasConceptScore W2538629088C2778677889 @default.
- W2538629088 hasConceptScore W2538629088C2781161787 @default.
- W2538629088 hasConceptScore W2538629088C2781192897 @default.
- W2538629088 hasConceptScore W2538629088C2908647359 @default.
- W2538629088 hasConceptScore W2538629088C548259974 @default.
- W2538629088 hasConceptScore W2538629088C71924100 @default.
- W2538629088 hasConceptScore W2538629088C89916169 @default.
- W2538629088 hasConceptScore W2538629088C99454951 @default.
- W2538629088 hasConceptScore W2538629088C99508421 @default.
- W2538629088 hasIssue "7S_Part_17" @default.
- W2538629088 hasLocation W25386290881 @default.
- W2538629088 hasOpenAccess W2538629088 @default.
- W2538629088 hasPrimaryLocation W25386290881 @default.
- W2538629088 hasRelatedWork W1965339644 @default.
- W2538629088 hasRelatedWork W2156294540 @default.
- W2538629088 hasRelatedWork W2159419408 @default.
- W2538629088 hasRelatedWork W2168893651 @default.
- W2538629088 hasRelatedWork W2357078099 @default.
- W2538629088 hasRelatedWork W2519051677 @default.
- W2538629088 hasRelatedWork W2611800695 @default.
- W2538629088 hasRelatedWork W2620768635 @default.
- W2538629088 hasRelatedWork W3145486478 @default.
- W2538629088 hasRelatedWork W4296825676 @default.
- W2538629088 hasVolume "12" @default.
- W2538629088 isParatext "false" @default.
- W2538629088 isRetracted "false" @default.
- W2538629088 magId "2538629088" @default.
- W2538629088 workType "article" @default.