FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2539032971> ?p ?o ?g. }

• W2539032971 endingPage "235" @default.
• W2539032971 startingPage "226" @default.
• W2539032971 abstract "The nitric oxide (NO•) metabolites nitrite and nitrate exert antihypertensive effects by mechanisms that involve gastric formation of S-nitrosothiols. However, while the use of antiseptic mouthwash (AM) is known to attenuate the responses to nitrate by disrupting its enterosalivary cycle, there is little information about whether AM attenuates the effects of orally administered nitrite. We hypothesized that the antihypertensive effects of orally administered nitrite would not be prevented by AM because, in contrast to oral nitrate, oral nitrite could promote S-nitrosothiols formation in the stomach without intereference by AM. Chronic effects of oral nitrite or nitrate were studied in two-kidney, one-clip (2K1C) hypertensive rats (and normotensive controls) treated with AM (or vehicle) once/day. We found that orally administered nitrite exerts antihypertensive effects that were not affected by AM. This finding contrasts with lack of antihypertensive responses to oral nitrate in 2K1C hypertensive rats treated with AM. Nitrite and nitrate treatments increased plasma nitrites, nitrates, and S-nitrosothiols concentrations. However, while treatment with AM attenuated the increases in plasma nitrite concentrations after both nitrite and nitrate treatments, AM attenuated the increases in S-nitrosothiols in nitrate-treated rats, but not in nitrite-treated rats. Moreover, AM attenuated vascular S-nitrosylation (detected by the SNO-RAC method) after nitrate, but not after nitrite treatment. Significant correlations were found between the hypotensive responses and S-nitrosothiols, and vascular S-nitrosylation levels. These results show for the first time that oral nitrite exerts antihypertensive effects notwithstanding the fact that antiseptic mouthwash disrupts the enterosalivary circulation of nitrate. Our results support a major role for S-nitrosothiols formation resulting in vascular S-nitrosylation as a key mechanism for the antihypertensive effects of both oral nitrite and nitrate." @default.
• W2539032971 created "2016-10-28" @default.
• W2539032971 creator A5002216895 @default.
• W2539032971 creator A5005565627 @default.
• W2539032971 creator A5006663847 @default.
• W2539032971 creator A5016463511 @default.
• W2539032971 creator A5024452132 @default.
• W2539032971 creator A5025281456 @default.
• W2539032971 creator A5039974725 @default.
• W2539032971 date "2016-12-01" @default.
• W2539032971 modified "2023-09-27" @default.
• W2539032971 title "Oral nitrite circumvents antiseptic mouthwash-induced disruption of enterosalivary circuit of nitrate and promotes nitrosation and blood pressure lowering effect" @default.
• W2539032971 cites W1119734502 @default.
• W2539032971 cites W1511302815 @default.
• W2539032971 cites W1533731827 @default.
• W2539032971 cites W1753393634 @default.
• W2539032971 cites W1965950958 @default.
• W2539032971 cites W1970169137 @default.
• W2539032971 cites W1974083352 @default.
• W2539032971 cites W1974569195 @default.
• W2539032971 cites W1986703419 @default.
• W2539032971 cites W1988778394 @default.
• W2539032971 cites W2002338268 @default.
• W2539032971 cites W2003946735 @default.
• W2539032971 cites W2009798374 @default.
• W2539032971 cites W2013052071 @default.
• W2539032971 cites W2017907872 @default.
• W2539032971 cites W2023421218 @default.
• W2539032971 cites W2024487462 @default.
• W2539032971 cites W2027439180 @default.
• W2539032971 cites W2030950447 @default.
• W2539032971 cites W2033357754 @default.
• W2539032971 cites W2036352285 @default.
• W2539032971 cites W2044950850 @default.
• W2539032971 cites W2051071984 @default.
• W2539032971 cites W2051209160 @default.
• W2539032971 cites W2053807731 @default.
• W2539032971 cites W2062912375 @default.
• W2539032971 cites W2065320565 @default.
• W2539032971 cites W2077390291 @default.
• W2539032971 cites W2085050015 @default.
• W2539032971 cites W2087384948 @default.
• W2539032971 cites W2091892600 @default.
• W2539032971 cites W2094077539 @default.
• W2539032971 cites W2100756743 @default.
• W2539032971 cites W2105080404 @default.
• W2539032971 cites W2111609140 @default.
• W2539032971 cites W2112453730 @default.
• W2539032971 cites W2125647807 @default.
• W2539032971 cites W2126330593 @default.
• W2539032971 cites W2128632568 @default.
• W2539032971 cites W2129415401 @default.
• W2539032971 cites W2130121105 @default.
• W2539032971 cites W2133236934 @default.
• W2539032971 cites W2142613692 @default.
• W2539032971 cites W2144413971 @default.
• W2539032971 cites W2145989199 @default.
• W2539032971 cites W2161221966 @default.
• W2539032971 cites W2192919500 @default.
• W2539032971 cites W2478599067 @default.
• W2539032971 cites W2505175538 @default.
• W2539032971 cites W772307155 @default.
• W2539032971 cites W833501392 @default.
• W2539032971 doi "https://doi.org/10.1016/j.freeradbiomed.2016.10.013" @default.
• W2539032971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27769921" @default.
• W2539032971 hasPublicationYear "2016" @default.
• W2539032971 type Work @default.
• W2539032971 sameAs 2539032971 @default.
• W2539032971 citedByCount "32" @default.
• W2539032971 countsByYear W25390329712017 @default.
• W2539032971 countsByYear W25390329712018 @default.
• W2539032971 countsByYear W25390329712019 @default.
• W2539032971 countsByYear W25390329712020 @default.
• W2539032971 countsByYear W25390329712021 @default.
• W2539032971 countsByYear W25390329712022 @default.
• W2539032971 countsByYear W25390329712023 @default.
• W2539032971 crossrefType "journal-article" @default.
• W2539032971 hasAuthorship W2539032971A5002216895 @default.
• W2539032971 hasAuthorship W2539032971A5005565627 @default.
• W2539032971 hasAuthorship W2539032971A5006663847 @default.
• W2539032971 hasAuthorship W2539032971A5016463511 @default.
• W2539032971 hasAuthorship W2539032971A5024452132 @default.
• W2539032971 hasAuthorship W2539032971A5025281456 @default.
• W2539032971 hasAuthorship W2539032971A5039974725 @default.
• W2539032971 hasBestOaLocation W25390329711 @default.
• W2539032971 hasConcept C178790620 @default.
• W2539032971 hasConcept C181199279 @default.
• W2539032971 hasConcept C185592680 @default.
• W2539032971 hasConcept C2776179834 @default.
• W2539032971 hasConcept C2776384668 @default.
• W2539032971 hasConcept C2777056448 @default.
• W2539032971 hasConcept C2778784160 @default.
• W2539032971 hasConcept C2780795997 @default.
• W2539032971 hasConcept C2781460226 @default.
• W2539032971 hasConcept C2910772780 @default.
• W2539032971 hasConcept C45068187 @default.
• W2539032971 hasConcept C519581460 @default.
• W2539032971 hasConcept C55493867 @default.

• next