FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2539364080> ?p ?o ?g. }

• W2539364080 endingPage "2497" @default.
• W2539364080 startingPage "2484" @default.
• W2539364080 abstract "DNGR-1 is receptor expressed by certain dendritic cell (DC) subsets and by DC precursors in mouse. It possesses a C-type lectin-like domain (CTLD) followed by a poorly characterized neck region coupled to a transmembrane region and short intracellular tail. The CTLD of DNGR-1 binds F-actin exposed by dead cell corpses and causes the receptor to signal and potentiate cross-presentation of dead cell-associated antigens by DCs. Here, we describe a conformational change that occurs in the neck region of DNGR-1 in a pH- and ionic strength-dependent manner and that controls cross-presentation of dead cell-associated antigens. We identify residues in the neck region that, when mutated, lock DNGR-1 in one of the two conformational states to potentiate cross-presentation. In contrast, we show that chimeric proteins in which the neck region of DNGR-1 is replaced by that of unrelated C-type lectin receptors fail to promote cross-presentation. Our results suggest that the neck region of DNGR-1 is an integral receptor component that senses receptor progression through the endocytic pathway and has evolved to maximize extraction of antigens from cell corpses, coupling DNGR-1 function to its cellular localization." @default.
• W2539364080 created "2016-10-28" @default.
• W2539364080 creator A5025058594 @default.
• W2539364080 creator A5027125016 @default.
• W2539364080 creator A5039240766 @default.
• W2539364080 creator A5043170875 @default.
• W2539364080 creator A5055637943 @default.
• W2539364080 creator A5072204509 @default.
• W2539364080 date "2016-10-17" @default.
• W2539364080 modified "2023-10-18" @default.
• W2539364080 title "A <scp>pH</scp> ‐ and ionic strength‐dependent conformational change in the neck region regulates <scp>DNGR</scp> ‐1 function in dendritic cells" @default.
• W2539364080 cites W1492794688 @default.
• W2539364080 cites W1532187041 @default.
• W2539364080 cites W1579140398 @default.
• W2539364080 cites W1669343833 @default.
• W2539364080 cites W1981817247 @default.
• W2539364080 cites W1982846895 @default.
• W2539364080 cites W1989270637 @default.
• W2539364080 cites W1994182910 @default.
• W2539364080 cites W1995629350 @default.
• W2539364080 cites W1997511430 @default.
• W2539364080 cites W2002863574 @default.
• W2539364080 cites W2007478258 @default.
• W2539364080 cites W2027500624 @default.
• W2539364080 cites W2038859753 @default.
• W2539364080 cites W2039730154 @default.
• W2539364080 cites W2044136163 @default.
• W2539364080 cites W2045160328 @default.
• W2539364080 cites W2046098930 @default.
• W2539364080 cites W2049122170 @default.
• W2539364080 cites W2055021349 @default.
• W2539364080 cites W2061058307 @default.
• W2539364080 cites W2066432176 @default.
• W2539364080 cites W2072691337 @default.
• W2539364080 cites W2074379065 @default.
• W2539364080 cites W2091019029 @default.
• W2539364080 cites W2106538910 @default.
• W2539364080 cites W2119252911 @default.
• W2539364080 cites W2136883776 @default.
• W2539364080 cites W2148643349 @default.
• W2539364080 cites W2168400876 @default.
• W2539364080 cites W2172266795 @default.
• W2539364080 cites W2321832119 @default.
• W2539364080 cites W2539364080 @default.
• W2539364080 doi "https://doi.org/10.15252/embj.201694695" @default.
• W2539364080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5109244" @default.
• W2539364080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27753620" @default.
• W2539364080 hasPublicationYear "2016" @default.
• W2539364080 type Work @default.
• W2539364080 sameAs 2539364080 @default.
• W2539364080 citedByCount "26" @default.
• W2539364080 countsByYear W25393640802016 @default.
• W2539364080 countsByYear W25393640802017 @default.
• W2539364080 countsByYear W25393640802018 @default.
• W2539364080 countsByYear W25393640802019 @default.
• W2539364080 countsByYear W25393640802020 @default.
• W2539364080 countsByYear W25393640802021 @default.
• W2539364080 countsByYear W25393640802022 @default.
• W2539364080 countsByYear W25393640802023 @default.
• W2539364080 crossrefType "journal-article" @default.
• W2539364080 hasAuthorship W2539364080A5025058594 @default.
• W2539364080 hasAuthorship W2539364080A5027125016 @default.
• W2539364080 hasAuthorship W2539364080A5039240766 @default.
• W2539364080 hasAuthorship W2539364080A5043170875 @default.
• W2539364080 hasAuthorship W2539364080A5055637943 @default.
• W2539364080 hasAuthorship W2539364080A5072204509 @default.
• W2539364080 hasBestOaLocation W25393640801 @default.
• W2539364080 hasConcept C106257327 @default.
• W2539364080 hasConcept C12554922 @default.
• W2539364080 hasConcept C147483822 @default.
• W2539364080 hasConcept C153911025 @default.
• W2539364080 hasConcept C170493617 @default.
• W2539364080 hasConcept C203014093 @default.
• W2539364080 hasConcept C24530287 @default.
• W2539364080 hasConcept C2776090121 @default.
• W2539364080 hasConcept C2777339483 @default.
• W2539364080 hasConcept C2778170410 @default.
• W2539364080 hasConcept C2778973524 @default.
• W2539364080 hasConcept C28005876 @default.
• W2539364080 hasConcept C55493867 @default.
• W2539364080 hasConcept C79747257 @default.
• W2539364080 hasConcept C79879829 @default.
• W2539364080 hasConcept C83464605 @default.
• W2539364080 hasConcept C86803240 @default.
• W2539364080 hasConcept C8891405 @default.
• W2539364080 hasConcept C95444343 @default.
• W2539364080 hasConceptScore W2539364080C106257327 @default.
• W2539364080 hasConceptScore W2539364080C12554922 @default.
• W2539364080 hasConceptScore W2539364080C147483822 @default.
• W2539364080 hasConceptScore W2539364080C153911025 @default.
• W2539364080 hasConceptScore W2539364080C170493617 @default.
• W2539364080 hasConceptScore W2539364080C203014093 @default.
• W2539364080 hasConceptScore W2539364080C24530287 @default.
• W2539364080 hasConceptScore W2539364080C2776090121 @default.
• W2539364080 hasConceptScore W2539364080C2777339483 @default.
• W2539364080 hasConceptScore W2539364080C2778170410 @default.
• W2539364080 hasConceptScore W2539364080C2778973524 @default.
• W2539364080 hasConceptScore W2539364080C28005876 @default.

• next