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- W2539565501 endingPage "162" @default.
- W2539565501 startingPage "153" @default.
- W2539565501 abstract "Abstract An efficient and convenient one‐pot procedure for the stereoselective catalytic synthesis of ring‐substituted [amino(phenyl)methyl]phosphonates has been developed. The enantioselective hydrogenation of easily available diisopropyl ( Z )‐[aryl(phenylhydrazono)methyl]phosphonates using palladium(II) acetate as a precatalyst, ( R )‐2,2′‐bis(diphenylphosphino)‐5,5′‐dichloro‐6,6′‐dimethoxy‐1,1′‐biphenyl [( R )‐Cl–MeO‐BIPHEP] as a ligand, and (1 S )‐(+)‐10‐camphorsulfonic acid as an activator in a mixture of 2,2,2‐trifluoroethanol and methylene chloride at ambient temperature results in the formation of corresponding [aryl(2‐phenylhydrazino)methyl]phosphonates. The subsequent cleavage of the N−N bond has been accomplished with molecular hydrogen after the addition of palladium on carbon and methanol into crude reaction mixture to afford the optically active [amino(aryl)methyl]phosphonates. The method is operationally simple and provides an appreciable enantioselectivity up to 98 % ee . magnified image" @default.
- W2539565501 created "2016-11-04" @default.
- W2539565501 creator A5007996916 @default.
- W2539565501 creator A5017559111 @default.
- W2539565501 creator A5082710282 @default.
- W2539565501 creator A5087087375 @default.
- W2539565501 date "2016-12-09" @default.
- W2539565501 modified "2023-10-13" @default.
- W2539565501 title "One-Pot Two-Step Synthesis of Optically Active<i>α</i>-Amino Phosphonates by Palladium-Catalyzed Hydrogenation/Hydrogenolysis of<i>α</i>-Hydrazono Phosphonates" @default.
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