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- W2539724837 abstract "BackgroundFibrinogen concentrate can improve clot firmness and offers a better safety profile than platelet concentrates. Reduction or avoidance of blood transfusions represents a strategy to reduce associated risks. We investigated whether supplementation of fibrinogen concentrate ex vivo can compensate for clot strength as compared with platelet transfusion in vivo.MethodsOne hundred patients in need of platelet transfusion (PT) were enrolled. Blood samples were collected immediately before PT and at 1 h and 24 h after PT. Fibrinogen concentrate was added to these citrated whole blood samples at concentrations of 50, 100, 200 and 400 mg kg−1 and the maximum clot firmness (MCF) was analysed using ROTEM thromboelastometry.ResultsFibrinogen supplementation increased MCF significantly and dose-dependently before and after PT. The effect of fibrinogen concentrate (equivalent to doses of 100 and 200 mg kg−1) ex vivo was comparable to that of PT in vivo, whereas 400 mg kg−1 fibrinogen significantly improved MCF compared with PT (P < 0.001).ConclusionsFibrinogen concentrate can match the effect of PT on MCF in thrombocytopenia. This potential alternative haemostatic intervention should be evaluated in clinical trials." @default.
- W2539724837 created "2016-11-04" @default.
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- W2539724837 date "2016-11-01" @default.
- W2539724837 modified "2023-10-16" @default.
- W2539724837 title "Fibrinogen supplementation ex vivo increasesclot firmness comparable to platelet transfusion in thrombocytopenia" @default.
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- W2539724837 doi "https://doi.org/10.1093/bja/aew315" @default.
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