FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2539892457> ?p ?o ?g. }

• W2539892457 endingPage "1050" @default.
• W2539892457 startingPage "1042" @default.
• W2539892457 abstract "This study aimed to investigate the mechanism of the induction of apoptosis of human oral cancer cells by the scorpion venom peptide BmKn2. Human oral squamous carcinoma cells (HSC4), mouth epidermoid carcinoma cells (KB), human normal gingival cells (HGC) and dental pulp cells (DPC) were treated with BmKn-2 peptide for 24 h. Cell viability was determined by the MTT assay. Apoptosis was assessed using phase contrast microscopy, by propidium iodide (PI) staining to assess nuclear morphology and by Annexin V staining. Apoptotic signaling pathways were investigated by quantitative reverse transcription–polymerase chain reaction (RT-qPCR) and Western blotting. BmKn-2 showed potent cytotoxic effects towards both HSC4 and KB cells with the associated induction of apoptosis. The cells showed distinct morphological changes, nuclear disintegration and an increase in the number of Annexin V-positive cells. Interestingly, at concentrations which kill cancerous cells, BmKn-2 did not affect cell viability or mediate the induction of apoptosis in normal HGC or DPC. Induction of apoptosis by BmKn-2 in HSC4 and KB cells was associated with the activation of tumor suppress p53. Pro-apoptotic BAX expression was increased, whereas antiapoptotic BCL-2 expression was decreased in BmKn-2 exposed HSC4 and KB cells. BmKn-2 treated-oral cancer cells showed distinct upregulation of initiator caspase-9, with no effect on caspase-8 expression. Increased expression levels of executor caspases-3 and −7 were also found in treated cells for both oral cancers. This study has suggested for the first time that BmKn-2 exerts selective cytotoxic effects on human oral cancer cells by inducting apoptosis via a p53-dependent intrinsic apoptotic pathway. BmKn-2 peptide originally derived from a natural source shows great promise as a candidate treatment for oral cancer, with minimal effects on healthy tissue." @default.
• W2539892457 created "2016-11-04" @default.
• W2539892457 creator A5006213255 @default.
• W2539892457 creator A5013951510 @default.
• W2539892457 creator A5031271099 @default.
• W2539892457 creator A5033377541 @default.
• W2539892457 creator A5046061579 @default.
• W2539892457 creator A5049829407 @default.
• W2539892457 creator A5074342043 @default.
• W2539892457 creator A5084521790 @default.
• W2539892457 date "2016-12-01" @default.
• W2539892457 modified "2023-10-17" @default.
• W2539892457 title "The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells" @default.
• W2539892457 cites W1588493170 @default.
• W2539892457 cites W1973794835 @default.
• W2539892457 cites W1977258127 @default.
• W2539892457 cites W1979291608 @default.
• W2539892457 cites W1979995768 @default.
• W2539892457 cites W1980280881 @default.
• W2539892457 cites W1988108021 @default.
• W2539892457 cites W1990519619 @default.
• W2539892457 cites W1991865867 @default.
• W2539892457 cites W1998423564 @default.
• W2539892457 cites W1999660608 @default.
• W2539892457 cites W2023794283 @default.
• W2539892457 cites W2063435495 @default.
• W2539892457 cites W2073474576 @default.
• W2539892457 cites W2077754831 @default.
• W2539892457 cites W2084998196 @default.
• W2539892457 cites W2116859082 @default.
• W2539892457 cites W2130866079 @default.
• W2539892457 cites W2134048164 @default.
• W2539892457 cites W2134979684 @default.
• W2539892457 cites W2144284013 @default.
• W2539892457 cites W2149293843 @default.
• W2539892457 cites W2150195627 @default.
• W2539892457 cites W2159247973 @default.
• W2539892457 cites W2160733129 @default.
• W2539892457 cites W2186226299 @default.
• W2539892457 cites W2346456510 @default.
• W2539892457 cites W4229662680 @default.
• W2539892457 doi "https://doi.org/10.1016/j.biopha.2016.10.041" @default.
• W2539892457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27780132" @default.
• W2539892457 hasPublicationYear "2016" @default.
• W2539892457 type Work @default.
• W2539892457 sameAs 2539892457 @default.
• W2539892457 citedByCount "16" @default.
• W2539892457 countsByYear W25398924572017 @default.
• W2539892457 countsByYear W25398924572019 @default.
• W2539892457 countsByYear W25398924572020 @default.
• W2539892457 countsByYear W25398924572021 @default.
• W2539892457 countsByYear W25398924572022 @default.
• W2539892457 countsByYear W25398924572023 @default.
• W2539892457 crossrefType "journal-article" @default.
• W2539892457 hasAuthorship W2539892457A5006213255 @default.
• W2539892457 hasAuthorship W2539892457A5013951510 @default.
• W2539892457 hasAuthorship W2539892457A5031271099 @default.
• W2539892457 hasAuthorship W2539892457A5033377541 @default.
• W2539892457 hasAuthorship W2539892457A5046061579 @default.
• W2539892457 hasAuthorship W2539892457A5049829407 @default.
• W2539892457 hasAuthorship W2539892457A5074342043 @default.
• W2539892457 hasAuthorship W2539892457A5084521790 @default.
• W2539892457 hasConcept C121608353 @default.
• W2539892457 hasConcept C153911025 @default.
• W2539892457 hasConcept C154317977 @default.
• W2539892457 hasConcept C185592680 @default.
• W2539892457 hasConcept C190283241 @default.
• W2539892457 hasConcept C202751555 @default.
• W2539892457 hasConcept C2775934118 @default.
• W2539892457 hasConcept C2780783641 @default.
• W2539892457 hasConcept C31573885 @default.
• W2539892457 hasConcept C502942594 @default.
• W2539892457 hasConcept C53227056 @default.
• W2539892457 hasConcept C54355233 @default.
• W2539892457 hasConcept C55493867 @default.
• W2539892457 hasConcept C86803240 @default.
• W2539892457 hasConcept C88634738 @default.
• W2539892457 hasConcept C95444343 @default.
• W2539892457 hasConcept C96232424 @default.
• W2539892457 hasConceptScore W2539892457C121608353 @default.
• W2539892457 hasConceptScore W2539892457C153911025 @default.
• W2539892457 hasConceptScore W2539892457C154317977 @default.
• W2539892457 hasConceptScore W2539892457C185592680 @default.
• W2539892457 hasConceptScore W2539892457C190283241 @default.
• W2539892457 hasConceptScore W2539892457C202751555 @default.
• W2539892457 hasConceptScore W2539892457C2775934118 @default.
• W2539892457 hasConceptScore W2539892457C2780783641 @default.
• W2539892457 hasConceptScore W2539892457C31573885 @default.
• W2539892457 hasConceptScore W2539892457C502942594 @default.
• W2539892457 hasConceptScore W2539892457C53227056 @default.
• W2539892457 hasConceptScore W2539892457C54355233 @default.
• W2539892457 hasConceptScore W2539892457C55493867 @default.
• W2539892457 hasConceptScore W2539892457C86803240 @default.
• W2539892457 hasConceptScore W2539892457C88634738 @default.
• W2539892457 hasConceptScore W2539892457C95444343 @default.
• W2539892457 hasConceptScore W2539892457C96232424 @default.
• W2539892457 hasLocation W25398924571 @default.
• W2539892457 hasLocation W25398924572 @default.

• next