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- W2539899411 abstract "Summary Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate protection are unknown. Using radiation chimeras, we were able to rule out a requirement for IL-17RA in the hematopoietic compartment. We saw remarkable concordance of IL-17-controlled gene expression in C. albicans -infected human oral epithelial cells (OECs) and in tongue tissue from mice with OPC. To interrogate the role of the IL-17R in OECs, we generated mice with conditional deletion of IL-17RA in superficial oral and esophageal epithelial cells ( Il17ra ΔK13 ). Following oral Candida infection, Il17ra ΔK13 mice exhibited fungal loads and weight loss indistinguishable from Il17ra −/− mice. Susceptibility in Il17ra ΔK13 mice correlated with expression of the antimicrobial peptide β-defensin 3 (BD3, Defb3 ). Consistently, Defb3 −/− mice were susceptible to OPC. Thus, OECs dominantly control IL-17R-dependent responses to OPC through regulation of BD3 expression." @default.
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- W2539899411 date "2016-11-01" @default.
- W2539899411 modified "2023-10-17" @default.
- W2539899411 title "IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis" @default.
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- W2539899411 cites W1766634910 @default.
- W2539899411 cites W1800708805 @default.
- W2539899411 cites W1911254661 @default.
- W2539899411 cites W1912289137 @default.
- W2539899411 cites W1934986900 @default.
- W2539899411 cites W1960011333 @default.
- W2539899411 cites W1969696561 @default.
- W2539899411 cites W1977723888 @default.
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- W2539899411 doi "https://doi.org/10.1016/j.chom.2016.10.001" @default.
- W2539899411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5147498" @default.
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- W2539899411 hasPublicationYear "2016" @default.
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