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• W2539919329 abstract "Background: The objective of this study was to evaluate the antimicrobial performance of a rifampin/minocycline-coated, non–cross-linked, acellular porcine dermal matrix (XenMatrix AB) compared to an uncoated, non–cross-linked, acellular porcine dermal matrix (Strattice) after implantation/inoculation with methicillin-resistant Staphylococcus aureus or Escherichia coli in a dorsal rabbit model. Methods: Forty male New Zealand White rabbits were bilaterally implanted with XenMatrix AB or Strattice grafts and inoculated with clinically isolated methicillin-resistant S. aureus (5 × 10 7 colony-forming units/ml) or E. coli (1 × 10 7 colony-forming units/ml). At 2 and 8 weeks, sites were analyzed for viable methicillin-resistant S. aureus / E. coli colony-forming units, abscess formation, and histologic response ( n = 5 rabbits per group per bacterium per time point). Results: XenMatrix AB completely inhibited bacterial colonization of the graft, inhibited abscess formation, reduced inflammation and encapsulation, and improved neovascularization compared with Strattice. XenMatrix AB implants exhibited significantly fewer colony-forming units compared with Strattice implants at 2 weeks (methicillin-resistant S. aureus ) ( p < 0.01) and at 2 and 8 weeks ( E. coli ) ( p < 0.05). In addition, XenMatrix AB implants demonstrated a significantly lower abscess score at 2 weeks (methicillin-resistant S. aureus ) and 8 weeks ( E. coli ) ( p < 0.01 in both cases). For both types of bacteria and both time points evaluated, XenMatrix AB implants exhibited minimal inflammation and encapsulation and a lack of neutrophils. In contrast, Strattice implants displayed marked inflammatory and neutrophilic responses and moderate encapsulation. Conclusions: This study demonstrated the antimicrobial performance of a rifampin/minocycline-coated bioprosthetic (XenMatrix AB) in a rabbit inoculation model. XenMatrix AB completely inhibited bacterial colonization of the graft, with minimal host inflammation and encapsulation, and improved neovascularization compared with Strattice." @default.
• W2539919329 created "2016-11-04" @default.
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• W2539919329 date "2016-11-01" @default.
• W2539919329 modified "2023-09-26" @default.
• W2539919329 title "Comparison of Antibiotic-Coated versus Uncoated Porcine Dermal Matrix" @default.
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• W2539919329 doi "https://doi.org/10.1097/prs.0000000000002688" @default.
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