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- W2540066182 endingPage "e1251539" @default.
- W2540066182 startingPage "e1251539" @default.
- W2540066182 abstract "The chimeric antigen receptor (CAR) is a genetically engineered receptor that combines a scFv domain, which specifically recognizes the tumor-specific antigen, with T cell activation domains. CAR-T cell therapies have demonstrated tremendous efficacy against hematologic malignancies in many clinical trials. Recent studies have extended these efforts to the treatment of solid tumors. However, the outcomes of CAR-T cell therapy for solid tumors are not as remarkable as the outcomes have been for hematologic malignancies. A series of hurdles has arisen with respect to CAR-T cell-based immunotherapy, which needs to be overcome to target solid tumors. The major challenge for CAR-T cell therapy in solid tumors is the selection of the appropriate specific antigen to demarcate the tumor from normal tissue. In this review, we discuss the application of CAR-T cells to gastrointestinal and hepatic carcinomas in preclinical and clinical research. Furthermore, we analyze the usefulness of several specific markers in the study of gastrointestinal tumors and hepatic carcinoma." @default.
- W2540066182 created "2016-11-04" @default.
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- W2540066182 creator A5068218262 @default.
- W2540066182 creator A5089655271 @default.
- W2540066182 date "2016-10-28" @default.
- W2540066182 modified "2023-10-16" @default.
- W2540066182 title "CAR-T cell therapy in gastrointestinal tumors and hepatic carcinoma: From bench to bedside" @default.
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