Matches in SemOpenAlex for { <https://semopenalex.org/work/W2540358509> ?p ?o ?g. }
- W2540358509 endingPage "65" @default.
- W2540358509 startingPage "55" @default.
- W2540358509 abstract "Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is confined to ependymal cells in the adult spinal cord which could be targeted for non-invasive SCI therapy. However, ependymal cells are an understudied cell population. Taking advantage of transgenic lines, we characterize the appearance and potential of ependymal cells during development. We show that spinal cord stem cell potential in vitro is contained within these cells by birth. Moreover, juvenile cultures generate more neurospheres and more oligodendrocytes than adult ones. Interestingly, juvenile ependymal cells in vivo contribute to glial scar formation after severe but not mild SCI, due to a more effective sealing of the lesion by other glial cells. This study highlights the importance of the age-dependent potential of stem cells and post-SCI environment in order to utilize ependymal cell's regenerative potential." @default.
- W2540358509 created "2016-11-04" @default.
- W2540358509 creator A5005385777 @default.
- W2540358509 creator A5013416685 @default.
- W2540358509 creator A5016857689 @default.
- W2540358509 creator A5025270532 @default.
- W2540358509 creator A5044059436 @default.
- W2540358509 creator A5071533204 @default.
- W2540358509 date "2016-11-01" @default.
- W2540358509 modified "2023-10-05" @default.
- W2540358509 title "Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time" @default.
- W2540358509 cites W123993916 @default.
- W2540358509 cites W1541950618 @default.
- W2540358509 cites W1557538973 @default.
- W2540358509 cites W1590831986 @default.
- W2540358509 cites W1591103981 @default.
- W2540358509 cites W1723367680 @default.
- W2540358509 cites W1807507622 @default.
- W2540358509 cites W1981203912 @default.
- W2540358509 cites W1981556150 @default.
- W2540358509 cites W1986236443 @default.
- W2540358509 cites W1994674541 @default.
- W2540358509 cites W1996243257 @default.
- W2540358509 cites W1998384354 @default.
- W2540358509 cites W2006075702 @default.
- W2540358509 cites W2010378000 @default.
- W2540358509 cites W2016043593 @default.
- W2540358509 cites W2028664124 @default.
- W2540358509 cites W2047585900 @default.
- W2540358509 cites W2047661701 @default.
- W2540358509 cites W2047678214 @default.
- W2540358509 cites W2047724409 @default.
- W2540358509 cites W2052604373 @default.
- W2540358509 cites W2055847790 @default.
- W2540358509 cites W2058089532 @default.
- W2540358509 cites W2062366535 @default.
- W2540358509 cites W2065262203 @default.
- W2540358509 cites W2083946660 @default.
- W2540358509 cites W2089234060 @default.
- W2540358509 cites W2091317796 @default.
- W2540358509 cites W2101363175 @default.
- W2540358509 cites W2104968232 @default.
- W2540358509 cites W2128475302 @default.
- W2540358509 cites W2139208934 @default.
- W2540358509 cites W2148806905 @default.
- W2540358509 cites W2156354373 @default.
- W2540358509 cites W2156757115 @default.
- W2540358509 cites W2161456562 @default.
- W2540358509 cites W2288805393 @default.
- W2540358509 cites W2335534790 @default.
- W2540358509 cites W2509896909 @default.
- W2540358509 cites W2522568367 @default.
- W2540358509 doi "https://doi.org/10.1016/j.ebiom.2016.10.035" @default.
- W2540358509 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5264475" @default.
- W2540358509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27818039" @default.
- W2540358509 hasPublicationYear "2016" @default.
- W2540358509 type Work @default.
- W2540358509 sameAs 2540358509 @default.
- W2540358509 citedByCount "46" @default.
- W2540358509 countsByYear W25403585092017 @default.
- W2540358509 countsByYear W25403585092018 @default.
- W2540358509 countsByYear W25403585092019 @default.
- W2540358509 countsByYear W25403585092020 @default.
- W2540358509 countsByYear W25403585092021 @default.
- W2540358509 countsByYear W25403585092022 @default.
- W2540358509 countsByYear W25403585092023 @default.
- W2540358509 crossrefType "journal-article" @default.
- W2540358509 hasAuthorship W2540358509A5005385777 @default.
- W2540358509 hasAuthorship W2540358509A5013416685 @default.
- W2540358509 hasAuthorship W2540358509A5016857689 @default.
- W2540358509 hasAuthorship W2540358509A5025270532 @default.
- W2540358509 hasAuthorship W2540358509A5044059436 @default.
- W2540358509 hasAuthorship W2540358509A5071533204 @default.
- W2540358509 hasBestOaLocation W25403585091 @default.
- W2540358509 hasConcept C104317684 @default.
- W2540358509 hasConcept C136834591 @default.
- W2540358509 hasConcept C142724271 @default.
- W2540358509 hasConcept C148738053 @default.
- W2540358509 hasConcept C162746124 @default.
- W2540358509 hasConcept C169760540 @default.
- W2540358509 hasConcept C20875687 @default.
- W2540358509 hasConcept C2776663378 @default.
- W2540358509 hasConcept C2778334475 @default.
- W2540358509 hasConcept C2780775167 @default.
- W2540358509 hasConcept C28328180 @default.
- W2540358509 hasConcept C2909073510 @default.
- W2540358509 hasConcept C529278444 @default.
- W2540358509 hasConcept C55493867 @default.
- W2540358509 hasConcept C71924100 @default.
- W2540358509 hasConcept C86803240 @default.
- W2540358509 hasConcept C95444343 @default.
- W2540358509 hasConceptScore W2540358509C104317684 @default.
- W2540358509 hasConceptScore W2540358509C136834591 @default.
- W2540358509 hasConceptScore W2540358509C142724271 @default.
- W2540358509 hasConceptScore W2540358509C148738053 @default.
- W2540358509 hasConceptScore W2540358509C162746124 @default.
- W2540358509 hasConceptScore W2540358509C169760540 @default.
- W2540358509 hasConceptScore W2540358509C20875687 @default.