Matches in SemOpenAlex for { <https://semopenalex.org/work/W2540651481> ?p ?o ?g. }
- W2540651481 abstract "During the last decades, we face an increasing interest in superior plants to supply growing demands for human and animal nutrition and for the developing bio-based economy. Presently, our limited understanding of their metabolism and its regulation hampers the targeted development of desired plant phenotypes. In this regard, systems biology, in particular the integration of metabolic and regulatory networks, is promising to broaden our knowledge and to further explore the biotechnological potential of plants. The thale cress Arabidopsis thaliana provides an ideal model to understand plant primary metabolism. To obtain insight into its functional properties, we constructed a large-scale metabolic network of the leaf of A. thaliana. It represented 511 reactions with spatial separation into compartments. Systematic analysis of this network, utilizing elementary flux modes, investigates metabolic capabilities of the plant and predicts relevant properties on the systems level: optimum pathway use for maximum growth and flux re-arrangement in response to environmental perturbation. Our computational model indicates that the A. thaliana leaf operates near its theoretical optimum flux state in the light, however, only in a narrow range of photon usage. The simulations further demonstrate that the natural day-night shift requires substantial re-arrangement of pathway flux between compartments: 89 reactions, involving redox and energy metabolism, substantially change the extent of flux, whereas 19 reactions even invert flux direction. The optimum set of anabolic pathways differs between day and night and is partly shifted between compartments. The integration with experimental transcriptome data pinpoints selected transcriptional changes that mediate the diurnal adaptation of the plant and superimpose the flux response. The successful application of predictive modelling in Arabidopsis thaliana can bring systems-biological interpretation of plant systems forward. Using the gained knowledge, metabolic engineering strategies to engage plants as biotechnological factories can be developed." @default.
- W2540651481 created "2016-11-04" @default.
- W2540651481 creator A5002106456 @default.
- W2540651481 creator A5011969791 @default.
- W2540651481 creator A5038268651 @default.
- W2540651481 creator A5044172043 @default.
- W2540651481 creator A5059986718 @default.
- W2540651481 creator A5072014427 @default.
- W2540651481 creator A5075432861 @default.
- W2540651481 creator A5084674318 @default.
- W2540651481 date "2016-10-29" @default.
- W2540651481 modified "2023-10-17" @default.
- W2540651481 title "In silico metabolic network analysis of Arabidopsis leaves" @default.
- W2540651481 cites W1793404797 @default.
- W2540651481 cites W1801503786 @default.
- W2540651481 cites W1963277947 @default.
- W2540651481 cites W1963297719 @default.
- W2540651481 cites W1969571365 @default.
- W2540651481 cites W1970083563 @default.
- W2540651481 cites W1972508433 @default.
- W2540651481 cites W1974202946 @default.
- W2540651481 cites W1974966154 @default.
- W2540651481 cites W1976719123 @default.
- W2540651481 cites W1979287129 @default.
- W2540651481 cites W1979294707 @default.
- W2540651481 cites W1982783237 @default.
- W2540651481 cites W1983174095 @default.
- W2540651481 cites W1986157873 @default.
- W2540651481 cites W1987198680 @default.
- W2540651481 cites W1989046619 @default.
- W2540651481 cites W1991888393 @default.
- W2540651481 cites W1992792323 @default.
- W2540651481 cites W1998057899 @default.
- W2540651481 cites W2000852928 @default.
- W2540651481 cites W2003122661 @default.
- W2540651481 cites W2005331290 @default.
- W2540651481 cites W2005669816 @default.
- W2540651481 cites W2008555977 @default.
- W2540651481 cites W2011307711 @default.
- W2540651481 cites W2011530219 @default.
- W2540651481 cites W2012689220 @default.
- W2540651481 cites W2013543988 @default.
- W2540651481 cites W2015600749 @default.
- W2540651481 cites W2022446046 @default.
- W2540651481 cites W2022567299 @default.
- W2540651481 cites W2026185694 @default.
- W2540651481 cites W2026205682 @default.
- W2540651481 cites W2027374968 @default.
- W2540651481 cites W2029144840 @default.
- W2540651481 cites W2036551273 @default.
- W2540651481 cites W2041020934 @default.
- W2540651481 cites W2041668772 @default.
- W2540651481 cites W2042040184 @default.
- W2540651481 cites W2044243244 @default.
- W2540651481 cites W2047106642 @default.
- W2540651481 cites W2048682154 @default.
- W2540651481 cites W2053680440 @default.
- W2540651481 cites W2056553121 @default.
- W2540651481 cites W2062229977 @default.
- W2540651481 cites W2065095031 @default.
- W2540651481 cites W2065603832 @default.
- W2540651481 cites W2066656769 @default.
- W2540651481 cites W2072543338 @default.
- W2540651481 cites W2072754018 @default.
- W2540651481 cites W2073269622 @default.
- W2540651481 cites W2074892828 @default.
- W2540651481 cites W2082091267 @default.
- W2540651481 cites W2084414310 @default.
- W2540651481 cites W2086091236 @default.
- W2540651481 cites W2086334942 @default.
- W2540651481 cites W2087872878 @default.
- W2540651481 cites W2089661821 @default.
- W2540651481 cites W2093736045 @default.
- W2540651481 cites W2095735864 @default.
- W2540651481 cites W2096077816 @default.
- W2540651481 cites W2098130298 @default.
- W2540651481 cites W2098709515 @default.
- W2540651481 cites W2099039198 @default.
- W2540651481 cites W2099825899 @default.
- W2540651481 cites W2099901681 @default.
- W2540651481 cites W2100481323 @default.
- W2540651481 cites W2100700481 @default.
- W2540651481 cites W2101778601 @default.
- W2540651481 cites W2102971996 @default.
- W2540651481 cites W2103328552 @default.
- W2540651481 cites W2108759090 @default.
- W2540651481 cites W2110355460 @default.
- W2540651481 cites W2111100441 @default.
- W2540651481 cites W2115803636 @default.
- W2540651481 cites W2116058003 @default.
- W2540651481 cites W2116882280 @default.
- W2540651481 cites W2123060905 @default.
- W2540651481 cites W2125325048 @default.
- W2540651481 cites W2128927770 @default.
- W2540651481 cites W2133556195 @default.
- W2540651481 cites W2134152363 @default.
- W2540651481 cites W2134245322 @default.
- W2540651481 cites W2135084125 @default.
- W2540651481 cites W2135871119 @default.
- W2540651481 cites W2141391392 @default.