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• W2540924107 abstract "Two new monoterpenoid indole alkaloids, melaxillines A (1) and B (2), together with four known alkaloids (3–6), were isolated from the roots of Melodinus axillaris. The structures were determined by extensive spectroscopic methods, including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data, and by comparison to literature data. New compounds 1–2 might be derived from a common precursor (3) by proposing their biogenetic route, and compound 1 represents the first Melodinus alkaloid featuring an ethyl acetate group skeleton at C-18. The anti-inflammatory effects of all the isolated compounds were evaluated by measuring the inhibitory ratios of β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor. Compounds 1–4 showed significant anti-inflammatory activities with IC50 values ranging from 1.51 to 21.56 μM, respectively." @default.
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• W2540924107 date "2016-12-01" @default.
• W2540924107 modified "2023-09-30" @default.
• W2540924107 title "Melaxillines A and B, monoterpenoid indole alkaloids from Melodinus axillaris" @default.
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• W2540924107 doi "https://doi.org/10.1016/j.fitote.2016.10.012" @default.
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