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- W2541034714 abstract "Abstract The biopharmaceutical industry is a maturing industry, now confronted with increasing generic competition and greater regulatory expectations. These drivers are motivating manufacturers to incorporate process modeling tools into their development and manufacturing practices to reduce development costs and shorten time-to-market. This is because the enhanced process understanding provided by modeling minimizes the number of experiments required to develop a process and reduces the risk of failure during scale-up. This chapter provides an overview of the current state of the process modeling field for bioprocess development. The scope is limited to modeling approaches based on first principles, with a focus on computational fluid dynamics because of the extensive application of this approach throughout the drug manufacturing process. The chapter begins with a review of the conservation equations for fluid flow, heat transfer, and species transport. Methodologies for applying these equations to predict the performance of selected upstream and downstream unit operations are then described. Throughout the chapter, case studies illustrate the application of process modeling to key design challenges facing today’s process development engineers." @default.
- W2541034714 created "2016-11-04" @default.
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- W2541034714 date "2017-01-01" @default.
- W2541034714 modified "2023-09-26" @default.
- W2541034714 title "Process modeling in the biopharmaceutical industry" @default.
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- W2541034714 doi "https://doi.org/10.1016/b978-0-08-100154-7.00014-4" @default.
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