Matches in SemOpenAlex for { <https://semopenalex.org/work/W2541203668> ?p ?o ?g. }
- W2541203668 abstract "Despite extensive research in the past decades, the influence of genetics on cognitive functions in schizophrenia remains unclear. Dystrobrevin-binding protein 1 (DTNBP1) is one of the most promising candidate genes in schizophrenia. An association of DTNBP1 with cognitive dysfunction, particularly memory impairment, has been reported in a number of studies. However, the results remain inconsistent. The aim of this study was to measure the association between DTNBP1 polymorphisms and cognitive domains in a well-characterized sample.Ninety-one clinically stable schizophrenia outpatients underwent a battery of cognitive tests. Six single nucleotide polymorphisms (SNPs) of DTNBP1 were genotyped in all participants. Statistical and multivariate analyses were performed.Factor analysis revealed 4 factors corresponding to distinct cognitive domains, namely sustained attention, set-shifting, executive functioning, and memory. We found a significant association of the rs909706 polymorphism with attention (p = 0.030) and a nonsignificant trend for set-shifting (p = 0.060). The other SNPs and haplotypes were not associated with cognitive function.Replication of this finding in a larger sample is needed in order to confirm the importance of this particular polymorphism in the genetics of schizophrenia, particularly the distinct cognitive domains. In conclusion, the present study supports the involvement of DTNBP1 in the regulation of cognitive processes and demonstrates association in particular with sustained attention and set-shifting in schizophrenia patients." @default.
- W2541203668 created "2016-11-04" @default.
- W2541203668 creator A5002200774 @default.
- W2541203668 creator A5006966463 @default.
- W2541203668 creator A5010994708 @default.
- W2541203668 creator A5040294643 @default.
- W2541203668 creator A5045838134 @default.
- W2541203668 creator A5048625350 @default.
- W2541203668 creator A5074466370 @default.
- W2541203668 date "2016-01-01" @default.
- W2541203668 modified "2023-10-16" @default.
- W2541203668 title "Association of Dystrobrevin-Binding Protein 1 Polymorphisms with Sustained Attention and Set-Shifting in Schizophrenia Patients" @default.
- W2541203668 cites W1718065612 @default.
- W2541203668 cites W1963673462 @default.
- W2541203668 cites W1963686948 @default.
- W2541203668 cites W1969699052 @default.
- W2541203668 cites W1972916674 @default.
- W2541203668 cites W1986206352 @default.
- W2541203668 cites W1987383840 @default.
- W2541203668 cites W1989508933 @default.
- W2541203668 cites W2008397268 @default.
- W2541203668 cites W2014813076 @default.
- W2541203668 cites W2026037056 @default.
- W2541203668 cites W2030705868 @default.
- W2541203668 cites W2041802575 @default.
- W2541203668 cites W2046365356 @default.
- W2541203668 cites W2050081796 @default.
- W2541203668 cites W2056355013 @default.
- W2541203668 cites W2060069187 @default.
- W2541203668 cites W2063918687 @default.
- W2541203668 cites W2073544062 @default.
- W2541203668 cites W2074446477 @default.
- W2541203668 cites W2076414256 @default.
- W2541203668 cites W2078544847 @default.
- W2541203668 cites W2080836123 @default.
- W2541203668 cites W2082310446 @default.
- W2541203668 cites W2083878136 @default.
- W2541203668 cites W2094384124 @default.
- W2541203668 cites W2101295234 @default.
- W2541203668 cites W2133558343 @default.
- W2541203668 cites W2138981262 @default.
- W2541203668 cites W2141186163 @default.
- W2541203668 cites W2151899057 @default.
- W2541203668 cites W2156420407 @default.
- W2541203668 cites W2162530578 @default.
- W2541203668 cites W2163214444 @default.
- W2541203668 cites W2165294134 @default.
- W2541203668 cites W2168855528 @default.
- W2541203668 cites W2170259615 @default.
- W2541203668 cites W2410747742 @default.
- W2541203668 cites W2599911490 @default.
- W2541203668 cites W293590370 @default.
- W2541203668 cites W2949561799 @default.
- W2541203668 doi "https://doi.org/10.1159/000450550" @default.
- W2541203668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27798936" @default.
- W2541203668 hasPublicationYear "2016" @default.
- W2541203668 type Work @default.
- W2541203668 sameAs 2541203668 @default.
- W2541203668 citedByCount "3" @default.
- W2541203668 countsByYear W25412036682017 @default.
- W2541203668 countsByYear W25412036682018 @default.
- W2541203668 crossrefType "journal-article" @default.
- W2541203668 hasAuthorship W2541203668A5002200774 @default.
- W2541203668 hasAuthorship W2541203668A5006966463 @default.
- W2541203668 hasAuthorship W2541203668A5010994708 @default.
- W2541203668 hasAuthorship W2541203668A5040294643 @default.
- W2541203668 hasAuthorship W2541203668A5045838134 @default.
- W2541203668 hasAuthorship W2541203668A5048625350 @default.
- W2541203668 hasAuthorship W2541203668A5074466370 @default.
- W2541203668 hasConcept C104317684 @default.
- W2541203668 hasConcept C118552586 @default.
- W2541203668 hasConcept C135763542 @default.
- W2541203668 hasConcept C142853389 @default.
- W2541203668 hasConcept C153209595 @default.
- W2541203668 hasConcept C15744967 @default.
- W2541203668 hasConcept C186413461 @default.
- W2541203668 hasConcept C2776412080 @default.
- W2541203668 hasConcept C542102704 @default.
- W2541203668 hasConcept C54355233 @default.
- W2541203668 hasConcept C70410870 @default.
- W2541203668 hasConcept C71924100 @default.
- W2541203668 hasConcept C86803240 @default.
- W2541203668 hasConceptScore W2541203668C104317684 @default.
- W2541203668 hasConceptScore W2541203668C118552586 @default.
- W2541203668 hasConceptScore W2541203668C135763542 @default.
- W2541203668 hasConceptScore W2541203668C142853389 @default.
- W2541203668 hasConceptScore W2541203668C153209595 @default.
- W2541203668 hasConceptScore W2541203668C15744967 @default.
- W2541203668 hasConceptScore W2541203668C186413461 @default.
- W2541203668 hasConceptScore W2541203668C2776412080 @default.
- W2541203668 hasConceptScore W2541203668C542102704 @default.
- W2541203668 hasConceptScore W2541203668C54355233 @default.
- W2541203668 hasConceptScore W2541203668C70410870 @default.
- W2541203668 hasConceptScore W2541203668C71924100 @default.
- W2541203668 hasConceptScore W2541203668C86803240 @default.
- W2541203668 hasLocation W25412036681 @default.
- W2541203668 hasLocation W25412036682 @default.
- W2541203668 hasOpenAccess W2541203668 @default.
- W2541203668 hasPrimaryLocation W25412036681 @default.
- W2541203668 hasRelatedWork W1608774374 @default.