FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2541272528> ?p ?o ?g. }

• W2541272528 endingPage "923" @default.
• W2541272528 startingPage "914" @default.
• W2541272528 abstract "Ketamine has been used safely in clinics for decades for analgesia and anesthesia. It is increasingly popular in clinical practice due to its new uses and importance for emergency procedures. It is known that ketamine is sequestered in the bone marrow and the major receptors for ketamine, noncompetitive N-methyl-d-aspartate receptors (NMDARs), are expressed in osteoclasts (OCs) and osteoblasts. However, the impact of ketamine on OCs or osteoblasts is unknown. In this study, we investigated the effects of ketamine on osteoclastogenesis and regulation of NMDARs expression in vitro. Bone marrows (BMs) or bone marrow macrophages (BMMs) were cultured in the presence of macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RANKL) with or without ketamine for up to 6 days. OC formation peaked at day 5. On day 5 of culture, ketamine inhibited OC formation from both BM and BMM cultures at clinically relevant concentrations (3-200 µM). Ketamine inhibited RANKL-induced expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) in BMM cultures. Inhibition of ketamine on RANKL-induced osteoclastogenesis is associated with down-regulation of NMDARs. In addition, ketamine significantly inhibited the M-CSF induced migration of BMMs, inhibited cell fusion and significantly increased mature OC apoptosis. We conclude that clinically relevant concentrations of ketamine inhibit OC formation in both BM and BMM cultures in vitro through inhibiting migration and fusion process and enhancing mature OC apoptosis. It is likely that ketamine regulates osteoclastogenesis, at least in part, via its effects on NMDAR expression. J. Cell. Biochem. 118: 914-923, 2017. © 2016 Wiley Periodicals, Inc." @default.
• W2541272528 created "2016-11-04" @default.
• W2541272528 creator A5013239844 @default.
• W2541272528 creator A5047961915 @default.
• W2541272528 creator A5068607756 @default.
• W2541272528 creator A5076036469 @default.
• W2541272528 date "2016-11-10" @default.
• W2541272528 modified "2023-10-05" @default.
• W2541272528 title "Clinically Relevant Concentrations of Ketamine Inhibit Osteoclast Formation In Vitro in Mouse Bone Marrow Cultures" @default.
• W2541272528 cites W15515072 @default.
• W2541272528 cites W1964210477 @default.
• W2541272528 cites W1986346121 @default.
• W2541272528 cites W1987292404 @default.
• W2541272528 cites W1994514751 @default.
• W2541272528 cites W2000494198 @default.
• W2541272528 cites W2007681965 @default.
• W2541272528 cites W2011633672 @default.
• W2541272528 cites W2015969526 @default.
• W2541272528 cites W2020533505 @default.
• W2541272528 cites W2025593998 @default.
• W2541272528 cites W2026158613 @default.
• W2541272528 cites W2028702261 @default.
• W2541272528 cites W2034124091 @default.
• W2541272528 cites W2034610934 @default.
• W2541272528 cites W2044440339 @default.
• W2541272528 cites W2045707567 @default.
• W2541272528 cites W2048299560 @default.
• W2541272528 cites W2048976632 @default.
• W2541272528 cites W2052830386 @default.
• W2541272528 cites W2054437388 @default.
• W2541272528 cites W2055280345 @default.
• W2541272528 cites W2055661286 @default.
• W2541272528 cites W2055842467 @default.
• W2541272528 cites W2059756482 @default.
• W2541272528 cites W2059761623 @default.
• W2541272528 cites W2061935788 @default.
• W2541272528 cites W2072774318 @default.
• W2541272528 cites W2081535550 @default.
• W2541272528 cites W2084202583 @default.
• W2541272528 cites W2091363925 @default.
• W2541272528 cites W2107533252 @default.
• W2541272528 cites W2108244474 @default.
• W2541272528 cites W2114374007 @default.
• W2541272528 cites W2117269242 @default.
• W2541272528 cites W2122518329 @default.
• W2541272528 cites W2139996507 @default.
• W2541272528 cites W2145936409 @default.
• W2541272528 cites W2151732631 @default.
• W2541272528 cites W2328844820 @default.
• W2541272528 cites W2362970587 @default.
• W2541272528 doi "https://doi.org/10.1002/jcb.25772" @default.
• W2541272528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27775174" @default.
• W2541272528 hasPublicationYear "2016" @default.
• W2541272528 type Work @default.
• W2541272528 sameAs 2541272528 @default.
• W2541272528 citedByCount "5" @default.
• W2541272528 countsByYear W25412725282018 @default.
• W2541272528 countsByYear W25412725282019 @default.
• W2541272528 countsByYear W25412725282020 @default.
• W2541272528 countsByYear W25412725282023 @default.
• W2541272528 crossrefType "journal-article" @default.
• W2541272528 hasAuthorship W2541272528A5013239844 @default.
• W2541272528 hasAuthorship W2541272528A5047961915 @default.
• W2541272528 hasAuthorship W2541272528A5068607756 @default.
• W2541272528 hasAuthorship W2541272528A5076036469 @default.
• W2541272528 hasConcept C126322002 @default.
• W2541272528 hasConcept C170493617 @default.
• W2541272528 hasConcept C185592680 @default.
• W2541272528 hasConcept C190283241 @default.
• W2541272528 hasConcept C202751555 @default.
• W2541272528 hasConcept C2776033226 @default.
• W2541272528 hasConcept C2779428903 @default.
• W2541272528 hasConcept C2780007613 @default.
• W2541272528 hasConcept C2780426850 @default.
• W2541272528 hasConcept C2780795376 @default.
• W2541272528 hasConcept C42219234 @default.
• W2541272528 hasConcept C55493867 @default.
• W2541272528 hasConcept C71924100 @default.
• W2541272528 hasConcept C88045685 @default.
• W2541272528 hasConcept C98274493 @default.
• W2541272528 hasConceptScore W2541272528C126322002 @default.
• W2541272528 hasConceptScore W2541272528C170493617 @default.
• W2541272528 hasConceptScore W2541272528C185592680 @default.
• W2541272528 hasConceptScore W2541272528C190283241 @default.
• W2541272528 hasConceptScore W2541272528C202751555 @default.
• W2541272528 hasConceptScore W2541272528C2776033226 @default.
• W2541272528 hasConceptScore W2541272528C2779428903 @default.
• W2541272528 hasConceptScore W2541272528C2780007613 @default.
• W2541272528 hasConceptScore W2541272528C2780426850 @default.
• W2541272528 hasConceptScore W2541272528C2780795376 @default.
• W2541272528 hasConceptScore W2541272528C42219234 @default.
• W2541272528 hasConceptScore W2541272528C55493867 @default.
• W2541272528 hasConceptScore W2541272528C71924100 @default.
• W2541272528 hasConceptScore W2541272528C88045685 @default.
• W2541272528 hasConceptScore W2541272528C98274493 @default.
• W2541272528 hasIssue "4" @default.
• W2541272528 hasLocation W25412725281 @default.
• W2541272528 hasLocation W25412725282 @default.

• next