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- W2541304001 endingPage "196" @default.
- W2541304001 startingPage "177" @default.
- W2541304001 abstract "The cohesin protein complex regulates multiple cellular events including sister chromatid cohesion and gene expression. Several distinct human diseases called cohesinopathies have been associated with genetic mutations in cohesin subunit genes or genes encoding regulators of cohesin function. Studies in different model systems, from yeast to mouse have provided insights into the molecular mechanisms of action of cohesin/cohesin regulators and their implications in the pathogenesis of cohesinopathies. The zebrafish has unique advantages for embryonic analyses and quantitative gene knockdown with morpholinos during the first few days of development, in contrast to knockouts of cohesin regulators in flies or mammals, which are either lethal as homozygotes or dramatically compensated for in heterozygotes. This has been particularly informative for Rad21, where a role in gene expression was first shown in zebrafish, and Nipbl, where the fish work revealed tissue-specific functions in heart, gut, and limbs, and long-range enhancer–promoter interactions that control Hox gene expression in vivo. Here we discuss the utility of the zebrafish in studying the developmental and pathogenic roles of cohesin." @default.
- W2541304001 created "2016-11-04" @default.
- W2541304001 creator A5013616060 @default.
- W2541304001 creator A5032617904 @default.
- W2541304001 date "2016-10-29" @default.
- W2541304001 modified "2023-09-24" @default.
- W2541304001 title "Zebrafish as a Model to Study Cohesin and Cohesinopathies" @default.
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