Matches in SemOpenAlex for { <https://semopenalex.org/work/W2541356010> ?p ?o ?g. }
- W2541356010 abstract "Disorders of hearing and balance are most commonly associated with damage to cochlear and vestibular hair cells or neurons. Although these cells are not capable of spontaneous regeneration, progenitor cells in the hearing and balance organs of the neonatal mammalian inner ear have the capacity to generate new hair cells after damage. To investigate whether these cells were restricted in their differentiation capacity, we assessed the phenotypes of differentiated progenitor cells isolated from three compartments of the inner ear - the vestibular and cochlear sensory epithelia and the spiral ganglion - by measuring electrophysiological properties and gene expression. Lgr5+ progenitor cells from the sensory epithelia gave rise to hair cell-like cells, but not neurons or glial cells. Newly created hair cell-like cells had hair bundle proteins, synaptic proteins, and membrane proteins characteristic of the compartment of origin. PLP+ glial cells from the spiral ganglion were identified as neural progenitors, which gave rise to neurons, astrocytes, and oligodendrocytes, but not hair cells. Thus, distinct progenitor populations from the neonatal inner ear differentiate to cell types associated with their organ of origin." @default.
- W2541356010 created "2016-11-04" @default.
- W2541356010 creator A5012007070 @default.
- W2541356010 creator A5061254120 @default.
- W2541356010 creator A5072316782 @default.
- W2541356010 creator A5072429681 @default.
- W2541356010 date "2016-01-01" @default.
- W2541356010 modified "2023-10-09" @default.
- W2541356010 title "Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs" @default.
- W2541356010 cites W1502631288 @default.
- W2541356010 cites W1503462679 @default.
- W2541356010 cites W1519680742 @default.
- W2541356010 cites W1537760924 @default.
- W2541356010 cites W1547150431 @default.
- W2541356010 cites W1617074755 @default.
- W2541356010 cites W169623269 @default.
- W2541356010 cites W1764972970 @default.
- W2541356010 cites W1875709550 @default.
- W2541356010 cites W1903915989 @default.
- W2541356010 cites W1967175995 @default.
- W2541356010 cites W1971625935 @default.
- W2541356010 cites W1974373320 @default.
- W2541356010 cites W1976040566 @default.
- W2541356010 cites W1976217597 @default.
- W2541356010 cites W1977604087 @default.
- W2541356010 cites W1980883991 @default.
- W2541356010 cites W1981860165 @default.
- W2541356010 cites W1982603620 @default.
- W2541356010 cites W1984425391 @default.
- W2541356010 cites W1990107804 @default.
- W2541356010 cites W1994402916 @default.
- W2541356010 cites W1994624028 @default.
- W2541356010 cites W1995145501 @default.
- W2541356010 cites W1995714714 @default.
- W2541356010 cites W1996266062 @default.
- W2541356010 cites W1998721838 @default.
- W2541356010 cites W1998964891 @default.
- W2541356010 cites W2000872405 @default.
- W2541356010 cites W2004332335 @default.
- W2541356010 cites W2005019117 @default.
- W2541356010 cites W2005586229 @default.
- W2541356010 cites W2006320251 @default.
- W2541356010 cites W2006623752 @default.
- W2541356010 cites W2009283506 @default.
- W2541356010 cites W2009441433 @default.
- W2541356010 cites W2011540182 @default.
- W2541356010 cites W2012694604 @default.
- W2541356010 cites W2013935392 @default.
- W2541356010 cites W2015819422 @default.
- W2541356010 cites W2016764434 @default.
- W2541356010 cites W2018682447 @default.
- W2541356010 cites W2019237061 @default.
- W2541356010 cites W2019496337 @default.
- W2541356010 cites W2023895951 @default.
- W2541356010 cites W2024299195 @default.
- W2541356010 cites W2024555306 @default.
- W2541356010 cites W2033347933 @default.
- W2541356010 cites W2034193769 @default.
- W2541356010 cites W2036567890 @default.
- W2541356010 cites W2038440214 @default.
- W2541356010 cites W2038717281 @default.
- W2541356010 cites W2040771287 @default.
- W2541356010 cites W2042914897 @default.
- W2541356010 cites W2043064965 @default.
- W2541356010 cites W2043093018 @default.
- W2541356010 cites W2043784071 @default.
- W2541356010 cites W2044413432 @default.
- W2541356010 cites W2046124242 @default.
- W2541356010 cites W2054535684 @default.
- W2541356010 cites W2057608998 @default.
- W2541356010 cites W2059605418 @default.
- W2541356010 cites W2063464173 @default.
- W2541356010 cites W2064128449 @default.
- W2541356010 cites W2064657201 @default.
- W2541356010 cites W2068465317 @default.
- W2541356010 cites W2068559327 @default.
- W2541356010 cites W2069515096 @default.
- W2541356010 cites W2077029464 @default.
- W2541356010 cites W2078884966 @default.
- W2541356010 cites W2079853168 @default.
- W2541356010 cites W2082745903 @default.
- W2541356010 cites W2084096953 @default.
- W2541356010 cites W2087188329 @default.
- W2541356010 cites W2087539633 @default.
- W2541356010 cites W2087618995 @default.
- W2541356010 cites W2088299102 @default.
- W2541356010 cites W2089071732 @default.
- W2541356010 cites W2089715002 @default.
- W2541356010 cites W2092597147 @default.
- W2541356010 cites W2096821559 @default.
- W2541356010 cites W2097498366 @default.
- W2541356010 cites W2098650397 @default.
- W2541356010 cites W2100007797 @default.
- W2541356010 cites W2100984050 @default.
- W2541356010 cites W2104412302 @default.
- W2541356010 cites W2111210385 @default.
- W2541356010 cites W2115290127 @default.
- W2541356010 cites W2124940469 @default.
- W2541356010 cites W2130813711 @default.
- W2541356010 cites W2132842784 @default.