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- W2541362014 abstract "The study was designed to assess the prevalence of comorbidities in patients with Hepatitis C Virus (HCV) and with concomitant HIV/HCV infection, and to estimate the healthcare costs associated with those comorbidities. An observational retrospective cohort analysis, using administrative and laboratory tests databases from 7 Local Health Units (LHUs) in Italy was designed. A preliminary analysis from one LHU was completed. Patients diagnosed (through hospitalisations, specific treatments or blood test results) with HCV or HIV/HCV co-infection between January 1st 2013 and December 31st 2015 were included. The date of the first diagnosis related to HCV or HIV/HCV co-infection was used as the index date. Clinical characteristics of patients enrolled in the study were investigated in the year before the index-date. All patients were followed for 1 year after the index-date. The preliminary analysis included a total of 105 patients mono-infected with HCV and 68 patients co-infected with HIV/HCV. Mean age was 53.8 and 54.3 years, respectively; 60% were male; 44% of HCV mono-infected patients had one comorbidity (rheumatologic/pulmonary conditions), 12% had two and 7% had three or more. Among HIV/HCV co-infected patients, 25% had one, 9% had two and 12% had three or more comorbidities. On average, the cost to the healthcare system of a co-infected patient was 45% more than mono-infected HCV patients. Pharmaceutical expenditure accounted for 51% and 87% of the total cost for mono-infected and HIV/HCV co-infected patients, respectively. The preliminary findings of this study showed that a significant proportion of HCV and HIV/HCV co-infected patients also experience comorbidities. As a consequence, antiviral strategies with minimal drug-drug interactions (DDIs) and favourable safety and tolerability profiles are necessary for optimal management of these patients. HIV/HCV co-infected patients required higher overall costs than HCV mono-infected ones. This was mainly due to drugs prescribed for comorbidities." @default.
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- W2541362014 date "2016-11-01" @default.
- W2541362014 modified "2023-09-29" @default.
- W2541362014 title "Burden Of Comorbidities In Hcv And Hiv/Hcv Patients. Real world evidence from italian administrative databases" @default.
- W2541362014 doi "https://doi.org/10.1016/j.jval.2016.09.377" @default.
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