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- W2541465498 abstract "DNA methylation at CpG sites is both heritable and influenced by environment, but the relative contributions of each to DNA methylation levels are unclear. We conducted a heritability analysis of CpG methylation in human CD4+ cells across 975 individuals from 163 families in the Genetics of Lipid-lowering Drugs and Diet Network (GOLDN). Based on a broad-sense heritability (H2) value threshold of 0.4, we identified 20,575 highly heritable CpGs among the 174,445 most variable autosomal CpGs (SD > 0.02). Tests for associations of heritable CpGs with genotype at 2,145,360 SNPs using 717 of 975 individuals showed that ~74% were cis-meQTLs (< 1 Mb away from the CpG), 6% of CpGs exhibited trans-meQTL associations (>1 Mb away from the CpG or located on a different chromosome), and 20% of CpGs showed no strong significant associations with genotype (based on a p-value threshold of 1e-7). Genes proximal to the genotype independent heritable CpGs were enriched for functional terms related to regulation of T cell activation. These CpGs were also among those that distinguished T cells from other blood cell lineages. Compared to genes proximal to meQTL-associated heritable CpGs, genotype independent heritable CpGs were moderately enriched in the same genomic regions that escape erasure during primordial germ cell development and could carry potential for generational transmission." @default.
- W2541465498 created "2016-11-04" @default.
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- W2541465498 date "2016-10-28" @default.
- W2541465498 modified "2023-09-28" @default.
- W2541465498 title "Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects" @default.
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- W2541465498 doi "https://doi.org/10.1371/journal.pone.0165488" @default.
- W2541465498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5085095" @default.
- W2541465498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27792787" @default.
- W2541465498 hasPublicationYear "2016" @default.
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