Matches in SemOpenAlex for { <https://semopenalex.org/work/W254147912> ?p ?o ?g. }
- W254147912 endingPage "4013" @default.
- W254147912 startingPage "4007" @default.
- W254147912 abstract "The C-terminus of nuclear lamins (CXXM) resembles a C-terminal motif (the CAAX box) of fungal mating factors and ras-related proteins. The CAAX box is subject to different types of post-translational modifications, including proteolytic processing, isoprenylation and carboxyl methylation. By peptide mapping we show that both chicken lamins A and B2 are processed proteolytically in vivo. However, whereas the entire CXXM motif is cleaved from lamin A, at most three C-terminal amino acids are removed from lamin B2. Following translation of cDNA-derived RNAs in reticulocyte lysates, lamin proteins specifically incorporate a derivative of [14C]mevalonic acid (MV), i.e. the precursor of a putative isoprenoid modification. Remarkably, no MV is incorporated into lamin B2 translated from a mutant cDNA encoding alanine instead of cysteine in the C-terminal CXXM motif. These results implicate this particular cysteine residue as the target for modification of lamin proteins by an isoprenoid MV derivative, and they indicate that isoprenylation is amenable to studies in cell-free systems. Moreover, our observations suggest that C-terminal processing of newly synthesized nuclear lamins is a multi-step process highly reminiscent of the pathway elaborated recently for ras-related proteins." @default.
- W254147912 created "2016-06-24" @default.
- W254147912 creator A5045543126 @default.
- W254147912 creator A5055957873 @default.
- W254147912 creator A5067286626 @default.
- W254147912 date "1989-12-01" @default.
- W254147912 modified "2023-10-18" @default.
- W254147912 title "Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif." @default.
- W254147912 cites W1480125182 @default.
- W254147912 cites W1490586953 @default.
- W254147912 cites W1492910694 @default.
- W254147912 cites W1500314244 @default.
- W254147912 cites W1527774170 @default.
- W254147912 cites W1536311055 @default.
- W254147912 cites W1563194997 @default.
- W254147912 cites W1564406238 @default.
- W254147912 cites W1568086666 @default.
- W254147912 cites W1569061529 @default.
- W254147912 cites W1571172000 @default.
- W254147912 cites W1594736139 @default.
- W254147912 cites W1606128793 @default.
- W254147912 cites W1639281802 @default.
- W254147912 cites W1819297632 @default.
- W254147912 cites W1978705807 @default.
- W254147912 cites W1996451278 @default.
- W254147912 cites W2003267467 @default.
- W254147912 cites W2008900071 @default.
- W254147912 cites W2010924785 @default.
- W254147912 cites W2011804485 @default.
- W254147912 cites W2016374284 @default.
- W254147912 cites W2018289835 @default.
- W254147912 cites W2025935725 @default.
- W254147912 cites W2032858454 @default.
- W254147912 cites W2034720843 @default.
- W254147912 cites W2038364318 @default.
- W254147912 cites W2072245143 @default.
- W254147912 cites W207418012 @default.
- W254147912 cites W2082833702 @default.
- W254147912 cites W2095534953 @default.
- W254147912 cites W2096101727 @default.
- W254147912 cites W2100837269 @default.
- W254147912 cites W2107771511 @default.
- W254147912 cites W2119297613 @default.
- W254147912 cites W2119932131 @default.
- W254147912 cites W2121897510 @default.
- W254147912 cites W2133362776 @default.
- W254147912 cites W2140558481 @default.
- W254147912 cites W2146525926 @default.
- W254147912 cites W2149077527 @default.
- W254147912 cites W2149467639 @default.
- W254147912 cites W2321742004 @default.
- W254147912 cites W2888511473 @default.
- W254147912 cites W289399362 @default.
- W254147912 cites W4234462880 @default.
- W254147912 doi "https://doi.org/10.1002/j.1460-2075.1989.tb08583.x" @default.
- W254147912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/401575" @default.
- W254147912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2686979" @default.
- W254147912 hasPublicationYear "1989" @default.
- W254147912 type Work @default.
- W254147912 sameAs 254147912 @default.
- W254147912 citedByCount "178" @default.
- W254147912 countsByYear W2541479122012 @default.
- W254147912 countsByYear W2541479122013 @default.
- W254147912 countsByYear W2541479122014 @default.
- W254147912 countsByYear W2541479122017 @default.
- W254147912 countsByYear W2541479122018 @default.
- W254147912 countsByYear W2541479122019 @default.
- W254147912 countsByYear W2541479122020 @default.
- W254147912 countsByYear W2541479122021 @default.
- W254147912 countsByYear W2541479122022 @default.
- W254147912 countsByYear W2541479122023 @default.
- W254147912 crossrefType "journal-article" @default.
- W254147912 hasAuthorship W254147912A5045543126 @default.
- W254147912 hasAuthorship W254147912A5055957873 @default.
- W254147912 hasAuthorship W254147912A5067286626 @default.
- W254147912 hasBestOaLocation W2541479122 @default.
- W254147912 hasConcept C104317684 @default.
- W254147912 hasConcept C153911025 @default.
- W254147912 hasConcept C167625842 @default.
- W254147912 hasConcept C179093185 @default.
- W254147912 hasConcept C181199279 @default.
- W254147912 hasConcept C187882448 @default.
- W254147912 hasConcept C2779201268 @default.
- W254147912 hasConcept C29512474 @default.
- W254147912 hasConcept C55493867 @default.
- W254147912 hasConcept C57790582 @default.
- W254147912 hasConcept C86339819 @default.
- W254147912 hasConcept C86803240 @default.
- W254147912 hasConcept C94912109 @default.
- W254147912 hasConcept C95444343 @default.
- W254147912 hasConceptScore W254147912C104317684 @default.
- W254147912 hasConceptScore W254147912C153911025 @default.
- W254147912 hasConceptScore W254147912C167625842 @default.
- W254147912 hasConceptScore W254147912C179093185 @default.
- W254147912 hasConceptScore W254147912C181199279 @default.
- W254147912 hasConceptScore W254147912C187882448 @default.
- W254147912 hasConceptScore W254147912C2779201268 @default.
- W254147912 hasConceptScore W254147912C29512474 @default.