Matches in SemOpenAlex for { <https://semopenalex.org/work/W2541536089> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2541536089 abstract "R advances in cell-type specific research tools have led to a growing appreciation for the role of neuroglia in CNS disorders. Astrocytes are a major glial-subtype that perform vital metabolic functions and interact extensively with synapses and microvessels, which show high vulnerability in Alzheimer’s disease (AD). At early stages of AD, “activated” astrocytes exhibit pronounced morphologic and biochemical changes, offering a largely-untapped source of druggable targets. Previously, we demonstrated that calcineurin (CN)/NFAT signaling is elevated in astrocytes early in AD and recapitulates many components of the activated phenotype. Our ongoing work exploits the activation status of the astrocytic CN/NFAT pathway in an attempt to (1) dissect the functional impact of activated astrocytes and (2) assess the therapeutic potential of these cells in experimental models of AD. Recently, we used adeno-associated virus (AAV) vectors bearing the astrocyte-specific Gfa2 promoter to deliver a CN/NFAT inhibitor (i.e. VIVIT) selectively to hippocampal astrocytes of APP/PS1 mice at the outset of amyloid pathology. At 10-months-post-injection, these mice exhibited less glial activation, reduced amyloid deposition, and improved synaptic and cognitive function relative to mice treated with control AAV vectors. Ongoing studies are investigating the mechanistic basis for the neuroprotective actions of AAV-Gfa2-VIVIT and are determining if similar beneficial effects occur when treatment is administered at late disease stages. The results provide some of the first direct evidence that activated astrocytes help drive neurologic dysfunction during AD and provide proof-of-principle for the development of similar astrocyte-based strategies for treating AD. Christopher M. Norris, J Alzheimers Dis Parkinsonism 2013, 3:4 http://dx.doi.org/10.4172/2161-0460.S1.002" @default.
- W2541536089 created "2016-11-04" @default.
- W2541536089 creator A5003116077 @default.
- W2541536089 date "2013-11-21" @default.
- W2541536089 modified "2023-09-23" @default.
- W2541536089 title "Targeting astrocytes as a therapeutic strategy for Alzheimer?s disease" @default.
- W2541536089 hasPublicationYear "2013" @default.
- W2541536089 type Work @default.
- W2541536089 sameAs 2541536089 @default.
- W2541536089 citedByCount "0" @default.
- W2541536089 crossrefType "journal-article" @default.
- W2541536089 hasAuthorship W2541536089A5003116077 @default.
- W2541536089 hasConcept C104317684 @default.
- W2541536089 hasConcept C126322002 @default.
- W2541536089 hasConcept C127716648 @default.
- W2541536089 hasConcept C128057223 @default.
- W2541536089 hasConcept C142724271 @default.
- W2541536089 hasConcept C169760540 @default.
- W2541536089 hasConcept C175344181 @default.
- W2541536089 hasConcept C189938988 @default.
- W2541536089 hasConcept C203014093 @default.
- W2541536089 hasConcept C25498285 @default.
- W2541536089 hasConcept C2776914184 @default.
- W2541536089 hasConcept C2777542381 @default.
- W2541536089 hasConcept C2777682930 @default.
- W2541536089 hasConcept C2779134260 @default.
- W2541536089 hasConcept C2779830541 @default.
- W2541536089 hasConcept C2780884517 @default.
- W2541536089 hasConcept C2781161787 @default.
- W2541536089 hasConcept C2911091166 @default.
- W2541536089 hasConcept C502032728 @default.
- W2541536089 hasConcept C529278444 @default.
- W2541536089 hasConcept C55493867 @default.
- W2541536089 hasConcept C71924100 @default.
- W2541536089 hasConcept C86803240 @default.
- W2541536089 hasConceptScore W2541536089C104317684 @default.
- W2541536089 hasConceptScore W2541536089C126322002 @default.
- W2541536089 hasConceptScore W2541536089C127716648 @default.
- W2541536089 hasConceptScore W2541536089C128057223 @default.
- W2541536089 hasConceptScore W2541536089C142724271 @default.
- W2541536089 hasConceptScore W2541536089C169760540 @default.
- W2541536089 hasConceptScore W2541536089C175344181 @default.
- W2541536089 hasConceptScore W2541536089C189938988 @default.
- W2541536089 hasConceptScore W2541536089C203014093 @default.
- W2541536089 hasConceptScore W2541536089C25498285 @default.
- W2541536089 hasConceptScore W2541536089C2776914184 @default.
- W2541536089 hasConceptScore W2541536089C2777542381 @default.
- W2541536089 hasConceptScore W2541536089C2777682930 @default.
- W2541536089 hasConceptScore W2541536089C2779134260 @default.
- W2541536089 hasConceptScore W2541536089C2779830541 @default.
- W2541536089 hasConceptScore W2541536089C2780884517 @default.
- W2541536089 hasConceptScore W2541536089C2781161787 @default.
- W2541536089 hasConceptScore W2541536089C2911091166 @default.
- W2541536089 hasConceptScore W2541536089C502032728 @default.
- W2541536089 hasConceptScore W2541536089C529278444 @default.
- W2541536089 hasConceptScore W2541536089C55493867 @default.
- W2541536089 hasConceptScore W2541536089C71924100 @default.
- W2541536089 hasConceptScore W2541536089C86803240 @default.
- W2541536089 hasLocation W25415360891 @default.
- W2541536089 hasOpenAccess W2541536089 @default.
- W2541536089 hasPrimaryLocation W25415360891 @default.
- W2541536089 hasRelatedWork W1509604932 @default.
- W2541536089 hasRelatedWork W1841772591 @default.
- W2541536089 hasRelatedWork W2011071982 @default.
- W2541536089 hasRelatedWork W2035431936 @default.
- W2541536089 hasRelatedWork W2516998486 @default.
- W2541536089 hasRelatedWork W2537448032 @default.
- W2541536089 hasRelatedWork W2735240222 @default.
- W2541536089 hasRelatedWork W2893554173 @default.
- W2541536089 hasRelatedWork W2901572343 @default.
- W2541536089 hasRelatedWork W2909644057 @default.
- W2541536089 hasRelatedWork W2911484089 @default.
- W2541536089 hasRelatedWork W2971125674 @default.
- W2541536089 hasRelatedWork W2976429613 @default.
- W2541536089 hasRelatedWork W3020538786 @default.
- W2541536089 hasRelatedWork W3087743103 @default.
- W2541536089 hasRelatedWork W3127432357 @default.
- W2541536089 hasRelatedWork W3137928502 @default.
- W2541536089 hasRelatedWork W3196330367 @default.
- W2541536089 hasRelatedWork W3197066362 @default.
- W2541536089 hasRelatedWork W427846973 @default.
- W2541536089 isParatext "false" @default.
- W2541536089 isRetracted "false" @default.
- W2541536089 magId "2541536089" @default.
- W2541536089 workType "article" @default.