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- W2541569086 abstract "Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling and cell division. We show that mechanical strain induced Src-dependent phosphorylation of Y654 β-catenin and increased β-catenin-mediated transcription in mammalian MDCK epithelial cells. Under these conditions, cells accumulated in S/G2 (independent of DNA damage) but did not divide. Activating β-catenin through Casein Kinase I inhibition or Wnt3A addition increased β-catenin-mediated transcription and strain-induced accumulation of cells in S/G2. Significantly, only the combination of mechanical strain and Wnt/β-catenin activation triggered cells in S/G2 to divide. These results indicate that strain-induced Src phosphorylation of β-catenin and Wnt-dependent β-catenin stabilization synergize to increase β-catenin-mediated transcription to levels required for mitosis. Thus, local Wnt signaling may fine-tune the effects of global mechanical strain to restrict cell divisions during tissue development and homeostasis." @default.
- W2541569086 created "2016-11-04" @default.
- W2541569086 creator A5003965162 @default.
- W2541569086 creator A5006724579 @default.
- W2541569086 creator A5008309794 @default.
- W2541569086 creator A5052283727 @default.
- W2541569086 creator A5077624417 @default.
- W2541569086 date "2016-10-26" @default.
- W2541569086 modified "2023-10-17" @default.
- W2541569086 title "Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis" @default.
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