FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2541840531> ?p ?o ?g. }

• W2541840531 endingPage "277" @default.
• W2541840531 startingPage "267" @default.
• W2541840531 abstract "Abstract OBJECTIVES In this study we aimed to identify novel metabolomic biomarkers suitable for improved diagnosis of heart failure with reduced ejection fraction (HFrEF). METHODS We prospectively recruited 887 individuals consisting of HFrEF patients with either ischemic (ICMP, n = 257) or nonischemic cardiomyopathy (NICMP, n = 269), healthy controls (n = 327), and patients with pulmonary diseases (n = 34). A single-center identification (n = 238) was followed by a multicenter confirmation study (n = 649). Plasma samples from the single-center study were subjected to metabolite profiling analysis to identify metabolomic features with potential as HFrEF biomarkers. A dedicated analytical protocol was developed for the routine analysis of selected metabolic features in the multicenter cohort. RESULTS In the single-center study, 92 of 181 metabolomic features with known chemical identity (51%) were significantly changed in HFrEF patients compared to healthy controls (P &lt;0.05). Three specific metabolomic features belonging to the lipid classes of sphingomyelins, triglycerides, and phosphatidylcholines were selected as the cardiac lipid panel (CLP) and analyzed in the multicenter study using the dedicated analytical protocol. The combination of the CLP with N-terminal pro–B-type natriuretic peptide (NT-proBNP) distinguished HFrEF patients from healthy controls with an area under the curve (AUC) of 0.97 (sensitivity 80.2%, specificity 97.6%) and was significantly superior compared to NT-proBNP alone (AUC = 0.93, sensitivity 81.7%, specificity 88.1%, P &lt;0.001), even in the subgroups with mildly reduced left ventricular EF (0.94 vs 0.87; P &lt;0.001) and asymptomatic patients (0.95 vs 0.91; P &lt;0.05). CONCLUSIONS The new metabolomic biomarker panel has the potential to improve HFrEF detection, even in mild and asymptomatic stages. The observed changes further indicate lipid alterations in the setting of HFrEF." @default.
• W2541840531 created "2016-11-04" @default.
• W2541840531 creator A5006969715 @default.
• W2541840531 creator A5008100709 @default.
• W2541840531 creator A5008704300 @default.
• W2541840531 creator A5010424704 @default.
• W2541840531 creator A5016114509 @default.
• W2541840531 creator A5018328821 @default.
• W2541840531 creator A5019765467 @default.
• W2541840531 creator A5024585720 @default.
• W2541840531 creator A5033002544 @default.
• W2541840531 creator A5034800453 @default.
• W2541840531 creator A5037092104 @default.
• W2541840531 creator A5039221753 @default.
• W2541840531 creator A5049262839 @default.
• W2541840531 creator A5055511768 @default.
• W2541840531 creator A5069873182 @default.
• W2541840531 creator A5070548943 @default.
• W2541840531 creator A5071108350 @default.
• W2541840531 creator A5072737089 @default.
• W2541840531 creator A5089677448 @default.
• W2541840531 date "2017-01-01" @default.
• W2541840531 modified "2023-09-30" @default.
• W2541840531 title "A Novel Lipid Biomarker Panel for the Detection of Heart Failure with Reduced Ejection Fraction" @default.
• W2541840531 cites W1509445416 @default.
• W2541840531 cites W177249847 @default.
• W2541840531 cites W1969889522 @default.
• W2541840531 cites W1971541774 @default.
• W2541840531 cites W1974438296 @default.
• W2541840531 cites W1999815460 @default.
• W2541840531 cites W2016433470 @default.
• W2541840531 cites W2018082119 @default.
• W2541840531 cites W2025559579 @default.
• W2541840531 cites W2035598079 @default.
• W2541840531 cites W2054822403 @default.
• W2541840531 cites W2067198284 @default.
• W2541840531 cites W2067266234 @default.
• W2541840531 cites W2070654125 @default.
• W2541840531 cites W2096248193 @default.
• W2541840531 cites W2099769151 @default.
• W2541840531 cites W2101914549 @default.
• W2541840531 cites W2105763343 @default.
• W2541840531 cites W2115764880 @default.
• W2541840531 cites W2122825543 @default.
• W2541840531 cites W2153131788 @default.
• W2541840531 cites W2165025270 @default.
• W2541840531 cites W288292848 @default.
• W2541840531 cites W4293204946 @default.
• W2541840531 cites W4294541781 @default.
• W2541840531 doi "https://doi.org/10.1373/clinchem.2016.257279" @default.
• W2541840531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28062623" @default.
• W2541840531 hasPublicationYear "2017" @default.
• W2541840531 type Work @default.
• W2541840531 sameAs 2541840531 @default.
• W2541840531 citedByCount "19" @default.
• W2541840531 countsByYear W25418405312017 @default.
• W2541840531 countsByYear W25418405312018 @default.
• W2541840531 countsByYear W25418405312019 @default.
• W2541840531 countsByYear W25418405312020 @default.
• W2541840531 countsByYear W25418405312021 @default.
• W2541840531 countsByYear W25418405312022 @default.
• W2541840531 countsByYear W25418405312023 @default.
• W2541840531 crossrefType "journal-article" @default.
• W2541840531 hasAuthorship W2541840531A5006969715 @default.
• W2541840531 hasAuthorship W2541840531A5008100709 @default.
• W2541840531 hasAuthorship W2541840531A5008704300 @default.
• W2541840531 hasAuthorship W2541840531A5010424704 @default.
• W2541840531 hasAuthorship W2541840531A5016114509 @default.
• W2541840531 hasAuthorship W2541840531A5018328821 @default.
• W2541840531 hasAuthorship W2541840531A5019765467 @default.
• W2541840531 hasAuthorship W2541840531A5024585720 @default.
• W2541840531 hasAuthorship W2541840531A5033002544 @default.
• W2541840531 hasAuthorship W2541840531A5034800453 @default.
• W2541840531 hasAuthorship W2541840531A5037092104 @default.
• W2541840531 hasAuthorship W2541840531A5039221753 @default.
• W2541840531 hasAuthorship W2541840531A5049262839 @default.
• W2541840531 hasAuthorship W2541840531A5055511768 @default.
• W2541840531 hasAuthorship W2541840531A5069873182 @default.
• W2541840531 hasAuthorship W2541840531A5070548943 @default.
• W2541840531 hasAuthorship W2541840531A5071108350 @default.
• W2541840531 hasAuthorship W2541840531A5072737089 @default.
• W2541840531 hasAuthorship W2541840531A5089677448 @default.
• W2541840531 hasBestOaLocation W25418405311 @default.
• W2541840531 hasConcept C126322002 @default.
• W2541840531 hasConcept C164705383 @default.
• W2541840531 hasConcept C185592680 @default.
• W2541840531 hasConcept C21565614 @default.
• W2541840531 hasConcept C2775846464 @default.
• W2541840531 hasConcept C2775915353 @default.
• W2541840531 hasConcept C2778198053 @default.
• W2541840531 hasConcept C2780073493 @default.
• W2541840531 hasConcept C2781197716 @default.
• W2541840531 hasConcept C55493867 @default.
• W2541840531 hasConcept C60644358 @default.
• W2541840531 hasConcept C71924100 @default.
• W2541840531 hasConcept C76318530 @default.
• W2541840531 hasConcept C78085059 @default.
• W2541840531 hasConcept C86803240 @default.

• next