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- W2541856909 abstract "MicroRNA are well-established players in post-transcriptional gene regulation. However, information on the effects of microRNA deregulation mainly relies on bioinformatic prediction of potential targets, whereas proof of the direct physical microRNA/target messenger RNA interaction is mostly lacking. Within the International Cancer Genome Consortium Project “Determining Molecular Mechanisms in Malignant Lymphoma by Sequencing”, we performed miRnome sequencing from 16 Burkitt lymphomas, 19 diffuse large B-cell lymphomas, and 21 follicular lymphomas. Twenty-two miRNA separated Burkitt lymphomas from diffuse large B-cell lymphomas/follicular lymphomas, of which 13 have shown regulation by MYC. Moreover, we found expression of three hitherto unreported microRNA. Additionally, we detected recurrent mutations of hsa-miR-142 in diffuse large B-cell lymphomas and follicular lymphomas, and editing of the hsa-miR-376 cluster, providing evidence for microRNA editing in lymphomagenesis. To interrogate the direct physical interactions of microRNA with messenger RNA, we performed Argonaute-2 photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipitation experiments. MicroRNA directly targeted 208 messsenger RNA in the Burkitt lymphomas and 328 messenger RNA in the non-Burkitt lymphoma models. This integrative analysis discovered several regulatory pathways of relevance in lymphomagenesis including Ras, PI3K-Akt and MAPK signaling pathways, also recurrently deregulated in lymphomas by mutations. Our dataset reveals that messenger RNA deregulation through microRNA is a highly relevant mechanism in lymphomagenesis." @default.
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- W2541856909 date "2016-07-06" @default.
- W2541856909 modified "2023-10-16" @default.
- W2541856909 title "Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis" @default.
- W2541856909 cites W1966082945 @default.
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- W2541856909 cites W1990690825 @default.
- W2541856909 cites W1990937720 @default.
- W2541856909 cites W1993652391 @default.
- W2541856909 cites W1996600340 @default.
- W2541856909 cites W1998413047 @default.
- W2541856909 cites W2000099335 @default.
- W2541856909 cites W2002520574 @default.
- W2541856909 cites W2006411367 @default.
- W2541856909 cites W2006704637 @default.
- W2541856909 cites W2013132763 @default.
- W2541856909 cites W2015782236 @default.
- W2541856909 cites W2018532884 @default.
- W2541856909 cites W2019103098 @default.
- W2541856909 cites W2038963685 @default.
- W2541856909 cites W2044390815 @default.
- W2541856909 cites W2045399297 @default.
- W2541856909 cites W2053003053 @default.
- W2541856909 cites W2062290101 @default.
- W2541856909 cites W2064919632 @default.
- W2541856909 cites W2066024172 @default.
- W2541856909 cites W2070146152 @default.
- W2541856909 cites W2080009925 @default.
- W2541856909 cites W2089743461 @default.
- W2541856909 cites W2092498599 @default.
- W2541856909 cites W2093200425 @default.
- W2541856909 cites W2096203569 @default.
- W2541856909 cites W2100555999 @default.
- W2541856909 cites W2103441770 @default.
- W2541856909 cites W2105613536 @default.
- W2541856909 cites W2107349444 @default.
- W2541856909 cites W2118028844 @default.
- W2541856909 cites W2120456037 @default.
- W2541856909 cites W2124709953 @default.
- W2541856909 cites W2132451283 @default.
- W2541856909 cites W2132685226 @default.
- W2541856909 cites W2138361806 @default.
- W2541856909 cites W2147246240 @default.
- W2541856909 cites W2148203455 @default.
- W2541856909 cites W2153806249 @default.
- W2541856909 cites W2155445572 @default.
- W2541856909 cites W2162312499 @default.
- W2541856909 cites W2165195065 @default.
- W2541856909 cites W2166170465 @default.
- W2541856909 cites W2400032569 @default.