Matches in SemOpenAlex for { <https://semopenalex.org/work/W2541968450> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2541968450 abstract "A144 The natural polyphenol curcumin has been demonstrated to be an effective agent against human cancer cells. This anti-cancer activity has been in part attributed to the inhibition of the nuclear factor of kappa B (NFkB), a transcription factor that controls the expression of genes involved in cellular survival, the anti-apoptotic machinery, and the inflammatory response. This knowledge has been exploited to develop curcumin-derived analogs, including the fluorinated EF24 compound, with higher potency in in vitro and in vivo models. In order to determine the mechanism of this analog, we examined the contribution of major mitogen-activated protein kinases (MAPKs) in EF24 induced signaling pathways and revealed the upregulated ERK, JNK, and p38 MAPK. We utilized pharmacological MAPK inhibitors to determine pathways that are important for EF24-induced cell death. Interestingly, EF24 in combination with pyridinyl-imidazole p38 MAPK inhibitors elicited cytotoxic synergy based on cell viability assays, combination index (CI) analysis, and colony formation assays. The synergy was associated with the induction of apoptosis as reflected by PARP cleavage and the accumulation of the sub-G1 fraction in flow cytometery. The combination of EF24 and p38 inhibitory compounds was also effective in multiple lung cancer cell lines possibly due to general upregulation of p38 MAPK by EF24 treatment. These studies suggest that p38 MAPK has a role in the survival response of lung cancer cells and is possibly one of the major survival pathways induced by EF24. Our finding suggests a potential therapeutic approach by combining a curcumin analog, such as EF24, with a p38 MAPK inhibitors for the effective treatment of lung cancer." @default.
- W2541968450 created "2016-11-04" @default.
- W2541968450 creator A5016747290 @default.
- W2541968450 creator A5032077625 @default.
- W2541968450 creator A5039814984 @default.
- W2541968450 creator A5072454821 @default.
- W2541968450 creator A5090987592 @default.
- W2541968450 date "2007-12-01" @default.
- W2541968450 modified "2023-09-26" @default.
- W2541968450 title "Synergistic anticancer potential of the combination of the novel curcumin analog EF24 and p38 MAPK inhibitors" @default.
- W2541968450 hasPublicationYear "2007" @default.
- W2541968450 type Work @default.
- W2541968450 sameAs 2541968450 @default.
- W2541968450 citedByCount "0" @default.
- W2541968450 crossrefType "journal-article" @default.
- W2541968450 hasAuthorship W2541968450A5016747290 @default.
- W2541968450 hasAuthorship W2541968450A5032077625 @default.
- W2541968450 hasAuthorship W2541968450A5039814984 @default.
- W2541968450 hasAuthorship W2541968450A5072454821 @default.
- W2541968450 hasAuthorship W2541968450A5090987592 @default.
- W2541968450 hasConcept C104317684 @default.
- W2541968450 hasConcept C127561419 @default.
- W2541968450 hasConcept C184235292 @default.
- W2541968450 hasConcept C185592680 @default.
- W2541968450 hasConcept C190283241 @default.
- W2541968450 hasConcept C2778250585 @default.
- W2541968450 hasConcept C502942594 @default.
- W2541968450 hasConcept C51551487 @default.
- W2541968450 hasConcept C55493867 @default.
- W2541968450 hasConcept C57074206 @default.
- W2541968450 hasConcept C86803240 @default.
- W2541968450 hasConcept C95444343 @default.
- W2541968450 hasConcept C98274493 @default.
- W2541968450 hasConceptScore W2541968450C104317684 @default.
- W2541968450 hasConceptScore W2541968450C127561419 @default.
- W2541968450 hasConceptScore W2541968450C184235292 @default.
- W2541968450 hasConceptScore W2541968450C185592680 @default.
- W2541968450 hasConceptScore W2541968450C190283241 @default.
- W2541968450 hasConceptScore W2541968450C2778250585 @default.
- W2541968450 hasConceptScore W2541968450C502942594 @default.
- W2541968450 hasConceptScore W2541968450C51551487 @default.
- W2541968450 hasConceptScore W2541968450C55493867 @default.
- W2541968450 hasConceptScore W2541968450C57074206 @default.
- W2541968450 hasConceptScore W2541968450C86803240 @default.
- W2541968450 hasConceptScore W2541968450C95444343 @default.
- W2541968450 hasConceptScore W2541968450C98274493 @default.
- W2541968450 hasLocation W25419684501 @default.
- W2541968450 hasOpenAccess W2541968450 @default.
- W2541968450 hasPrimaryLocation W25419684501 @default.
- W2541968450 hasRelatedWork W1161220759 @default.
- W2541968450 hasRelatedWork W1971392795 @default.
- W2541968450 hasRelatedWork W1991182145 @default.
- W2541968450 hasRelatedWork W2002021525 @default.
- W2541968450 hasRelatedWork W2017813632 @default.
- W2541968450 hasRelatedWork W2025963778 @default.
- W2541968450 hasRelatedWork W2041807155 @default.
- W2541968450 hasRelatedWork W2044621655 @default.
- W2541968450 hasRelatedWork W2065025147 @default.
- W2541968450 hasRelatedWork W2065393180 @default.
- W2541968450 hasRelatedWork W2071801925 @default.
- W2541968450 hasRelatedWork W2095442587 @default.
- W2541968450 hasRelatedWork W2132418802 @default.
- W2541968450 hasRelatedWork W2158448236 @default.
- W2541968450 hasRelatedWork W2313917931 @default.
- W2541968450 hasRelatedWork W2472904797 @default.
- W2541968450 hasRelatedWork W2510971238 @default.
- W2541968450 hasRelatedWork W2521676439 @default.
- W2541968450 hasRelatedWork W3047392336 @default.
- W2541968450 hasRelatedWork W3164950287 @default.
- W2541968450 hasVolume "16" @default.
- W2541968450 isParatext "false" @default.
- W2541968450 isRetracted "false" @default.
- W2541968450 magId "2541968450" @default.
- W2541968450 workType "article" @default.