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• W254199749 abstract "AbstractIn order to examine the involvement of oxidative stress in childhood-onset neurological disorders, we have performed immunohistochemistry in autopsy brains and enzyme-linked immunosorbent and colorimetric assays in cerebrospinal fluid and urine samples. Herein, we review findings in the literature and present the data of our preliminary studies on subjects with autism spectrum disorders and Rett syndrome. Next, the involvement of oxidative stress is addressed briefly in Down syndrome and cerebral palsy, including severe motor and intellectual disabilities. Last, we summarize our data on intractable epilepsy that has been published in previous papers, in addition to reviewing the findings in the literature. The link between oxidative stress and such entities remains controversial. However, it is possible that antioxidant therapy will be useful in each disorder.KeywordsAutism Spectrum DisorderCerebral PalsyDown SyndromeReactive Nitrogen SpeciesOxidative Stress MarkerThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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• W254199749 date "2014-01-01" @default.
• W254199749 modified "2023-09-27" @default.
• W254199749 title "Neurological Disorders (Especially Developmental Brain Disorders)" @default.
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• W254199749 doi "https://doi.org/10.1007/978-1-4939-0679-6_24" @default.
• W254199749 hasPublicationYear "2014" @default.
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