FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2542118333> ?p ?o ?g. }

• W2542118333 endingPage "16.2016" @default.
• W2542118333 startingPage "ENEURO.0221" @default.
• W2542118333 abstract "Abstract Shudderer ( Shu ) is an X-linked dominant mutation in Drosophila melanogaster identified more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and defects in reactive climbing behavior, and that these phenotypes were significantly suppressed when mutants were fed food containing lithium, a mood stabilizer used in the treatment of bipolar disorder (Williamson, 1982). This unique observation suggested that the Shu mutation affects genes involved in lithium-responsive neurobiological processes. In the present study, we identified Shu as a novel mutant allele of the voltage-gated sodium (Na v ) channel gene paralytic ( para ). Given that hypomorphic para alleles and RNA interference–mediated para knockdown reduced the severity of Shu phenotypes, Shu was classified as a para hypermorphic allele. We also demonstrated that lithium could improve the behavioral abnormalities displayed by other Na v mutants, including a fly model of the human generalized epilepsy with febrile seizures plus. Our electrophysiological analysis of Shu showed that lithium treatment did not acutely suppress Na v channel activity, indicating that the rescue effect of lithium resulted from chronic physiological adjustments to this drug. Microarray analysis revealed that lithium significantly alters the expression of various genes in Shu , including those involved in innate immune responses, amino acid metabolism, and oxidation-reduction processes, raising the interesting possibility that lithium-induced modulation of these biological pathways may contribute to such adjustments. Overall, our findings demonstrate that Na v channel mutants in Drosophila are valuable genetic tools for elucidating the effects of lithium on the nervous system in the context of neurophysiology and behavior." @default.
• W2542118333 created "2016-11-04" @default.
• W2542118333 creator A5010842750 @default.
• W2542118333 creator A5018783259 @default.
• W2542118333 creator A5021377062 @default.
• W2542118333 creator A5033913974 @default.
• W2542118333 creator A5073473042 @default.
• W2542118333 creator A5085914160 @default.
• W2542118333 creator A5088515926 @default.
• W2542118333 date "2016-09-01" @default.
• W2542118333 modified "2023-10-16" @default.
• W2542118333 title "Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the<i>Drosophila</i>Voltage-Gated Sodium Channel Gene<i>paralytic</i>" @default.
• W2542118333 cites W1500816198 @default.
• W2542118333 cites W1532984791 @default.
• W2542118333 cites W1577928045 @default.
• W2542118333 cites W1636334135 @default.
• W2542118333 cites W1895827734 @default.
• W2542118333 cites W1936722638 @default.
• W2542118333 cites W1947481567 @default.
• W2542118333 cites W1962484858 @default.
• W2542118333 cites W1967297467 @default.
• W2542118333 cites W1971067213 @default.
• W2542118333 cites W1972882396 @default.
• W2542118333 cites W1977943570 @default.
• W2542118333 cites W1978279909 @default.
• W2542118333 cites W1982469223 @default.
• W2542118333 cites W1983271741 @default.
• W2542118333 cites W1984187867 @default.
• W2542118333 cites W1985221543 @default.
• W2542118333 cites W1990296960 @default.
• W2542118333 cites W1991587314 @default.
• W2542118333 cites W1992117613 @default.
• W2542118333 cites W1993288432 @default.
• W2542118333 cites W1993506650 @default.
• W2542118333 cites W1995058974 @default.
• W2542118333 cites W1997045509 @default.
• W2542118333 cites W1998557470 @default.
• W2542118333 cites W1998752329 @default.
• W2542118333 cites W1999426696 @default.
• W2542118333 cites W2001465365 @default.
• W2542118333 cites W2006402788 @default.
• W2542118333 cites W2006996625 @default.
• W2542118333 cites W2007816528 @default.
• W2542118333 cites W2012598794 @default.
• W2542118333 cites W2015031388 @default.
• W2542118333 cites W2017807006 @default.
• W2542118333 cites W2018435113 @default.
• W2542118333 cites W2018582505 @default.
• W2542118333 cites W2018894929 @default.
• W2542118333 cites W2020797973 @default.
• W2542118333 cites W2020815630 @default.
• W2542118333 cites W2021191740 @default.
• W2542118333 cites W2022981588 @default.
• W2542118333 cites W2023167817 @default.
• W2542118333 cites W2023456394 @default.
• W2542118333 cites W2026125882 @default.
• W2542118333 cites W2026982076 @default.
• W2542118333 cites W2029195952 @default.
• W2542118333 cites W2030443339 @default.
• W2542118333 cites W2032972160 @default.
• W2542118333 cites W2041287250 @default.
• W2542118333 cites W2043867460 @default.
• W2542118333 cites W2050357864 @default.
• W2542118333 cites W2051788298 @default.
• W2542118333 cites W2055124287 @default.
• W2542118333 cites W2064166298 @default.
• W2542118333 cites W2064313388 @default.
• W2542118333 cites W2065742101 @default.
• W2542118333 cites W2068078405 @default.
• W2542118333 cites W2070042414 @default.
• W2542118333 cites W2071885245 @default.
• W2542118333 cites W2075109419 @default.
• W2542118333 cites W2078086032 @default.
• W2542118333 cites W2079353889 @default.
• W2542118333 cites W2083682478 @default.
• W2542118333 cites W2085107624 @default.
• W2542118333 cites W2085491896 @default.
• W2542118333 cites W2085968319 @default.
• W2542118333 cites W2086125969 @default.
• W2542118333 cites W2088863630 @default.
• W2542118333 cites W2097058534 @default.
• W2542118333 cites W2100671007 @default.
• W2542118333 cites W2102036006 @default.
• W2542118333 cites W2102549002 @default.
• W2542118333 cites W2104653131 @default.
• W2542118333 cites W2107277218 @default.
• W2542118333 cites W2108244474 @default.
• W2542118333 cites W2109534550 @default.
• W2542118333 cites W2110363413 @default.
• W2542118333 cites W2110363999 @default.
• W2542118333 cites W2112551261 @default.
• W2542118333 cites W2113544881 @default.
• W2542118333 cites W2115110458 @default.
• W2542118333 cites W2118397392 @default.
• W2542118333 cites W2121134263 @default.
• W2542118333 cites W2127263164 @default.
• W2542118333 cites W2127442418 @default.
• W2542118333 cites W2128896077 @default.

• next