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- W2542233234 abstract "The cellular redox state is important for the regulation of multiple functions and is essential for the maintenance of cellular homeostasis and antioxidant defense. In the excretory/secretory (E/S) products of Strongyloides ratti and Trichuris suis sequences for thioredoxin (Trx) and Trx-like protein (Trx-lp) were identified. To characterize the antioxidant Trx-lp and its interaction with the parasite’s mucosal habitat, S. ratti and T. suis Trx-lps were cloned and recombinantly expressed. The primary antioxidative activity was assured by reduction of insulin and IgM. Further analysis applying an in vitro mucosal 3D-cell culture model revealed that the secreted Trx-lps were able to bind to monocytic and intestinal epithelial cells and induce the time-dependent release of cytokines such as TNF- α , IL-22, and TSLP. In addition, the redox proteins also possessed chemotactic activity for monocytic THP-1 cells and fostered epithelial wound healing activity. These results confirm that the parasite-secreted Trx-lps are multifunctional proteins that can affect the host intestinal mucosa." @default.
- W2542233234 created "2016-11-04" @default.
- W2542233234 creator A5028385919 @default.
- W2542233234 creator A5028922669 @default.
- W2542233234 creator A5056837196 @default.
- W2542233234 creator A5069935672 @default.
- W2542233234 creator A5070772777 @default.
- W2542233234 creator A5081576727 @default.
- W2542233234 creator A5085226733 @default.
- W2542233234 creator A5089119041 @default.
- W2542233234 date "2016-01-01" @default.
- W2542233234 modified "2023-10-18" @default.
- W2542233234 title "Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic Nematodes<i>Strongyloides ratti</i>and<i>Trichuris suis</i>Affects Mucosal Homeostasis" @default.
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