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- W2542241331 abstract "Various mechanisms of resistance to ALK inhibitors in ALK rearranged adenocarcinomas are reported including secondary gatekeeper mutations, bypass signaling or ALK amplifications as the commonest ones. We report a new mechanism of resistance with transformation of adenocarcinoma into small cell lung cancer. A 53-year-old non-smoker woman, experienced cancer progression after two lines of ALK inhibitors. A new biopsy showed a small cell lung cancer. FISH revealed persistent ALK rearrangement with an atypical pattern and complete loss of the 5' region of the ALK gene." @default.
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- W2542241331 date "2016-12-01" @default.
- W2542241331 modified "2023-10-16" @default.
- W2542241331 title "Histological transformation of ALK rearranged adenocarcinoma into small cell lung cancer: A new mechanism of resistance to ALK inhibitors" @default.
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- W2542241331 doi "https://doi.org/10.1016/j.lungcan.2016.10.012" @default.
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