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- W2542253449 abstract "This chapter focuses on the involvement of the cerebral cortex in Huntington disease, with special emphasis on the link between cortical pathology and variable clinical manifestations. Huntington disease is an autosomal-dominant neurodegenerative disorder characterized by involuntary movements and cognitive and psychiatric disturbances. The disease is caused by an expansion of polyglutamine repeats in the N-terminal domain of the huntingtin protein from a genetic mutation in the HTT gene on human chromosome 4. The major pathosis occurs in the brain with profound degeneration in the forebrain regions, namely the striatum and the cerebral cortex. Despite the single gene etiology, there is major variability in the neuropathology, as well as major heterogeneity in the symptom profiles. Recent in vivo imaging and pathological studies have shown that cortical degeneration is related to variable symptomatology. Here, we summarize the recent progress on how cortical degeneration contributes to symptom heterogeneity in Huntington disease." @default.
- W2542253449 created "2016-11-04" @default.
- W2542253449 creator A5019180500 @default.
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- W2542253449 creator A5050134689 @default.
- W2542253449 creator A5073877662 @default.
- W2542253449 creator A5088282584 @default.
- W2542253449 date "2017-01-01" @default.
- W2542253449 modified "2023-10-14" @default.
- W2542253449 title "Huntington Disease" @default.
- W2542253449 cites W1489178621 @default.
- W2542253449 cites W1508843172 @default.
- W2542253449 cites W1548868716 @default.
- W2542253449 cites W1557351439 @default.
- W2542253449 cites W1639255528 @default.
- W2542253449 cites W1767788740 @default.
- W2542253449 cites W1949056714 @default.
- W2542253449 cites W1962249623 @default.
- W2542253449 cites W1965271417 @default.
- W2542253449 cites W1965816119 @default.
- W2542253449 cites W1968304311 @default.
- W2542253449 cites W1968700646 @default.
- W2542253449 cites W1970732501 @default.
- W2542253449 cites W1973055895 @default.
- W2542253449 cites W1973765221 @default.
- W2542253449 cites W1974548594 @default.
- W2542253449 cites W1974578944 @default.
- W2542253449 cites W1982138681 @default.
- W2542253449 cites W1982138826 @default.
- W2542253449 cites W1982780729 @default.
- W2542253449 cites W1985474993 @default.
- W2542253449 cites W1987519006 @default.
- W2542253449 cites W1990406694 @default.
- W2542253449 cites W1992622283 @default.
- W2542253449 cites W1993449159 @default.
- W2542253449 cites W1993790650 @default.
- W2542253449 cites W1996592124 @default.
- W2542253449 cites W1996789718 @default.
- W2542253449 cites W1997669050 @default.
- W2542253449 cites W1999783230 @default.
- W2542253449 cites W1999981386 @default.
- W2542253449 cites W2002559713 @default.
- W2542253449 cites W2002885460 @default.
- W2542253449 cites W2004564566 @default.
- W2542253449 cites W2006952111 @default.
- W2542253449 cites W2008561777 @default.
- W2542253449 cites W2011930181 @default.
- W2542253449 cites W2016430082 @default.
- W2542253449 cites W2016460575 @default.
- W2542253449 cites W2019977932 @default.
- W2542253449 cites W2020685601 @default.
- W2542253449 cites W2021549489 @default.
- W2542253449 cites W2023887531 @default.
- W2542253449 cites W2024492535 @default.
- W2542253449 cites W2026826561 @default.
- W2542253449 cites W2027726362 @default.
- W2542253449 cites W2028362961 @default.
- W2542253449 cites W2029984090 @default.
- W2542253449 cites W2033022824 @default.
- W2542253449 cites W2036685176 @default.
- W2542253449 cites W2038253384 @default.
- W2542253449 cites W2039436205 @default.
- W2542253449 cites W2041119962 @default.
- W2542253449 cites W2042739691 @default.
- W2542253449 cites W2043306767 @default.
- W2542253449 cites W2044030703 @default.
- W2542253449 cites W2046487631 @default.
- W2542253449 cites W2048713258 @default.
- W2542253449 cites W2050577770 @default.
- W2542253449 cites W2052935486 @default.
- W2542253449 cites W2053189650 @default.
- W2542253449 cites W2055551927 @default.
- W2542253449 cites W2057534170 @default.
- W2542253449 cites W2061536887 @default.
- W2542253449 cites W2065962160 @default.
- W2542253449 cites W2066128411 @default.
- W2542253449 cites W2068275936 @default.
- W2542253449 cites W2072697147 @default.
- W2542253449 cites W2075326685 @default.
- W2542253449 cites W2076044875 @default.
- W2542253449 cites W2076211806 @default.
- W2542253449 cites W2082056883 @default.
- W2542253449 cites W2084728929 @default.
- W2542253449 cites W2084849755 @default.
- W2542253449 cites W2087157508 @default.
- W2542253449 cites W2100264277 @default.
- W2542253449 cites W2102185402 @default.
- W2542253449 cites W2105402392 @default.
- W2542253449 cites W2106200048 @default.
- W2542253449 cites W2106964787 @default.
- W2542253449 cites W2110341842 @default.
- W2542253449 cites W2110387447 @default.
- W2542253449 cites W2110915363 @default.
- W2542253449 cites W2113547127 @default.
- W2542253449 cites W2113661629 @default.
- W2542253449 cites W2114032995 @default.
- W2542253449 cites W2115870221 @default.
- W2542253449 cites W2117341801 @default.