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• W2542256217 abstract "Neurotoxicity induced by early developmental exposure to volatile anesthetics is a characteristic of organisms across a wide range of species, extending from the nematode C. elegans to mammals. Prevention of anesthetic-induced neurotoxicity (AIN) will rely upon an understanding of its underlying mechanisms. However, no forward genetic screens have been undertaken to identify the critical pathways affected in AIN. By characterizing such pathways, we may identify mechanisms to eliminate isoflurane induced AIN in mammals. Chemotaxis in adult C. elegans after larval exposure to isoflurane was used to measure AIN. We initially compared changes in chemotaxis indices between classical mutants known to affect nervous system development adding mutants in response to data. Activation of specific genes was visualized using fluorescent markers. Animals were then treated with rapamycin or preconditioned with isoflurane to test effects on AIN. Forty-four mutations, as well as pharmacologic manipulations, identified two pathways, highly conserved from invertebrates to humans, that regulate AIN in C. elegans. Activation of one stress-protective pathway (DAF-2 dependent) eliminates AIN, while activation of a second stress-responsive pathway (endoplasmic reticulum (ER) associated stress) causes AIN. Pharmacologic inhibition of the mechanistic Target of Rapamycin (mTOR) blocks ER-stress and AIN. Preconditioning with isoflurane prior to larval exposure also inhibited AIN. Our data are best explained by a model in which isoflurane acutely inhibits mitochondrial function causing activation of responses that ultimately lead to ER-stress. The neurotoxic effect of isoflurane can be completely prevented by manipulations at multiple points in the pathways that control this response. Endogenous signaling pathways can be recruited to protect organisms from the neurotoxic effects of isoflurane." @default.
• W2542256217 created "2016-11-04" @default.
• W2542256217 creator A5000879558 @default.
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• W2542256217 date "2017-03-01" @default.
• W2542256217 modified "2023-10-08" @default.
• W2542256217 title "The genetics of isoflurane-induced developmental neurotoxicity" @default.
• W2542256217 cites W1168906471 @default.
• W2542256217 cites W1456730919 @default.
• W2542256217 cites W1486595217 @default.
• W2542256217 cites W1521704888 @default.
• W2542256217 cites W1540183702 @default.
• W2542256217 cites W1565010155 @default.
• W2542256217 cites W1577876369 @default.
• W2542256217 cites W1944127002 @default.
• W2542256217 cites W1963656740 @default.
• W2542256217 cites W1964880819 @default.
• W2542256217 cites W1965843055 @default.
• W2542256217 cites W1979705609 @default.
• W2542256217 cites W1985645688 @default.
• W2542256217 cites W1988255350 @default.
• W2542256217 cites W1990257793 @default.
• W2542256217 cites W1990353914 @default.
• W2542256217 cites W1991080848 @default.
• W2542256217 cites W1996551678 @default.
• W2542256217 cites W1998025917 @default.
• W2542256217 cites W1999151746 @default.
• W2542256217 cites W2000605336 @default.
• W2542256217 cites W2002996450 @default.
• W2542256217 cites W2006274062 @default.
• W2542256217 cites W2010583480 @default.
• W2542256217 cites W2011278616 @default.
• W2542256217 cites W2022554846 @default.
• W2542256217 cites W2024494094 @default.
• W2542256217 cites W2025483501 @default.
• W2542256217 cites W2026508759 @default.
• W2542256217 cites W2027977649 @default.
• W2542256217 cites W2028298077 @default.
• W2542256217 cites W2035863659 @default.
• W2542256217 cites W2036386225 @default.
• W2542256217 cites W2038120788 @default.
• W2542256217 cites W2039464456 @default.
• W2542256217 cites W2040949325 @default.
• W2542256217 cites W2044052768 @default.
• W2542256217 cites W2044747701 @default.
• W2542256217 cites W2045364112 @default.
• W2542256217 cites W2046835799 @default.
• W2542256217 cites W2047651061 @default.
• W2542256217 cites W2050717118 @default.
• W2542256217 cites W2052722944 @default.
• W2542256217 cites W2054251296 @default.
• W2542256217 cites W2056036930 @default.
• W2542256217 cites W2056306864 @default.
• W2542256217 cites W2057470782 @default.
• W2542256217 cites W2058904604 @default.
• W2542256217 cites W2060646721 @default.
• W2542256217 cites W2061902760 @default.
• W2542256217 cites W2065368498 @default.
• W2542256217 cites W2066180307 @default.
• W2542256217 cites W2074783650 @default.
• W2542256217 cites W2075182269 @default.
• W2542256217 cites W2077396037 @default.
• W2542256217 cites W2078632746 @default.
• W2542256217 cites W2080349795 @default.
• W2542256217 cites W2081277412 @default.
• W2542256217 cites W2085525271 @default.
• W2542256217 cites W2086515125 @default.
• W2542256217 cites W2090827413 @default.
• W2542256217 cites W2092358853 @default.
• W2542256217 cites W2093398809 @default.
• W2542256217 cites W2098134556 @default.
• W2542256217 cites W2098924417 @default.
• W2542256217 cites W2099763381 @default.
• W2542256217 cites W2100569554 @default.
• W2542256217 cites W2105641712 @default.
• W2542256217 cites W2107568807 @default.
• W2542256217 cites W2109296388 @default.
• W2542256217 cites W2109662861 @default.
• W2542256217 cites W2112728348 @default.
• W2542256217 cites W2116437559 @default.
• W2542256217 cites W2121227338 @default.
• W2542256217 cites W2123488223 @default.
• W2542256217 cites W2140400644 @default.
• W2542256217 cites W2140535675 @default.
• W2542256217 cites W2141043038 @default.
• W2542256217 cites W2153312037 @default.
• W2542256217 cites W2154108823 @default.
• W2542256217 cites W2156322705 @default.
• W2542256217 cites W2169696860 @default.
• W2542256217 cites W2260600928 @default.
• W2542256217 cites W2331258043 @default.
• W2542256217 doi "https://doi.org/10.1016/j.ntt.2016.10.012" @default.
• W2542256217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5367966" @default.
• W2542256217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27989695" @default.

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