FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2543129869> ?p ?o ?g. }

• W2543129869 endingPage "4533" @default.
• W2543129869 startingPage "4526" @default.
• W2543129869 abstract "Prostate cancer (PCa) is unique in its tendency to produce osteoblastic (OB) bone metastases. There are no existing therapies that specifically target the OB phase that affects 90% of men with bone metastatic disease. Prostatic acid phosphatase (PAP) is secreted by PCa cells in OB metastases and increases OB growth, differentiation, and bone mineralization. The purpose of this study was to investigate whether PAP effects on OB bone metastases are mediated by autocrine and/or paracrine alterations in the receptor activator of nuclear factor κ-B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system. To investigate whether PAP modulated these factors and altered the bone reaction, we knocked down PAP expression in VCaP cells and stably overexpressed PAP in PC3M cells, both derived from human PCa bone metastases. We show that knockdown of PAP in VCaP cells decreased OPG while increasing RANK/RANKL expression. Forced overexpression of PAP in PC3M cells had the inverse effect, increasing OPG while decreasing RANK/RANKL expression. Coculture of PCa cells with MC3T3 preosteoblasts also revealed a role for secretory PAP in OB-PCa cross talk. Reduced PAP expression in VCaP cells decreased MC3T3 proliferation and differentiation and reduced their OPG expression. PAP overexpression in PC3M cells altered the bone phenotype creating OB rather than osteolytic lesions in vivo using an intratibial model. These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases OPG and plays a critical role in the vicious cross talk between cancer and bone cells. These data suggest that inhibition of secretory PAP may be an effective strategy for PCa OB bone lesions." @default.
• W2543129869 created "2016-11-04" @default.
• W2543129869 creator A5007898120 @default.
• W2543129869 creator A5014280061 @default.
• W2543129869 creator A5040759015 @default.
• W2543129869 creator A5061826734 @default.
• W2543129869 creator A5066701958 @default.
• W2543129869 creator A5071752055 @default.
• W2543129869 creator A5075926965 @default.
• W2543129869 creator A5085576609 @default.
• W2543129869 date "2016-10-26" @default.
• W2543129869 modified "2023-10-01" @default.
• W2543129869 title "Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases" @default.
• W2543129869 cites W1602502274 @default.
• W2543129869 cites W1967274524 @default.
• W2543129869 cites W1981386560 @default.
• W2543129869 cites W1984673297 @default.
• W2543129869 cites W1985177598 @default.
• W2543129869 cites W2007538553 @default.
• W2543129869 cites W2008549629 @default.
• W2543129869 cites W2019008302 @default.
• W2543129869 cites W2038935694 @default.
• W2543129869 cites W2054783675 @default.
• W2543129869 cites W2061144117 @default.
• W2543129869 cites W2077641456 @default.
• W2543129869 cites W2101009063 @default.
• W2543129869 cites W2112078646 @default.
• W2543129869 cites W2154161543 @default.
• W2543129869 doi "https://doi.org/10.1210/en.2016-1606" @default.
• W2543129869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133341" @default.
• W2543129869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27783536" @default.
• W2543129869 hasPublicationYear "2016" @default.
• W2543129869 type Work @default.
• W2543129869 sameAs 2543129869 @default.
• W2543129869 citedByCount "15" @default.
• W2543129869 countsByYear W25431298692018 @default.
• W2543129869 countsByYear W25431298692019 @default.
• W2543129869 countsByYear W25431298692020 @default.
• W2543129869 countsByYear W25431298692021 @default.
• W2543129869 countsByYear W25431298692022 @default.
• W2543129869 countsByYear W25431298692023 @default.
• W2543129869 crossrefType "journal-article" @default.
• W2543129869 hasAuthorship W2543129869A5007898120 @default.
• W2543129869 hasAuthorship W2543129869A5014280061 @default.
• W2543129869 hasAuthorship W2543129869A5040759015 @default.
• W2543129869 hasAuthorship W2543129869A5061826734 @default.
• W2543129869 hasAuthorship W2543129869A5066701958 @default.
• W2543129869 hasAuthorship W2543129869A5071752055 @default.
• W2543129869 hasAuthorship W2543129869A5075926965 @default.
• W2543129869 hasAuthorship W2543129869A5085576609 @default.
• W2543129869 hasBestOaLocation W25431298691 @default.
• W2543129869 hasConcept C121608353 @default.
• W2543129869 hasConcept C126322002 @default.
• W2543129869 hasConcept C128240485 @default.
• W2543129869 hasConcept C134018914 @default.
• W2543129869 hasConcept C170033053 @default.
• W2543129869 hasConcept C170493617 @default.
• W2543129869 hasConcept C185592680 @default.
• W2543129869 hasConcept C2777783956 @default.
• W2543129869 hasConcept C2779428903 @default.
• W2543129869 hasConcept C2780192828 @default.
• W2543129869 hasConcept C2780426850 @default.
• W2543129869 hasConcept C2909639871 @default.
• W2543129869 hasConcept C502942594 @default.
• W2543129869 hasConcept C71924100 @default.
• W2543129869 hasConcept C7876069 @default.
• W2543129869 hasConcept C88045685 @default.
• W2543129869 hasConceptScore W2543129869C121608353 @default.
• W2543129869 hasConceptScore W2543129869C126322002 @default.
• W2543129869 hasConceptScore W2543129869C128240485 @default.
• W2543129869 hasConceptScore W2543129869C134018914 @default.
• W2543129869 hasConceptScore W2543129869C170033053 @default.
• W2543129869 hasConceptScore W2543129869C170493617 @default.
• W2543129869 hasConceptScore W2543129869C185592680 @default.
• W2543129869 hasConceptScore W2543129869C2777783956 @default.
• W2543129869 hasConceptScore W2543129869C2779428903 @default.
• W2543129869 hasConceptScore W2543129869C2780192828 @default.
• W2543129869 hasConceptScore W2543129869C2780426850 @default.
• W2543129869 hasConceptScore W2543129869C2909639871 @default.
• W2543129869 hasConceptScore W2543129869C502942594 @default.
• W2543129869 hasConceptScore W2543129869C71924100 @default.
• W2543129869 hasConceptScore W2543129869C7876069 @default.
• W2543129869 hasConceptScore W2543129869C88045685 @default.
• W2543129869 hasIssue "12" @default.
• W2543129869 hasLocation W25431298691 @default.
• W2543129869 hasLocation W25431298692 @default.
• W2543129869 hasLocation W25431298693 @default.
• W2543129869 hasLocation W25431298694 @default.
• W2543129869 hasOpenAccess W2543129869 @default.
• W2543129869 hasPrimaryLocation W25431298691 @default.
• W2543129869 hasRelatedWork W1093104327 @default.
• W2543129869 hasRelatedWork W1975953388 @default.
• W2543129869 hasRelatedWork W2009111528 @default.
• W2543129869 hasRelatedWork W2026854426 @default.
• W2543129869 hasRelatedWork W2054797498 @default.
• W2543129869 hasRelatedWork W2070413050 @default.
• W2543129869 hasRelatedWork W2150422194 @default.
• W2543129869 hasRelatedWork W2326832210 @default.

• next