FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2543242644> ?p ?o ?g. }

• W2543242644 endingPage "107" @default.
• W2543242644 startingPage "97" @default.
• W2543242644 abstract "Recent advances in genome-wide surveys have revealed a number of lepidopteran insect homologs of mammalian and Drosophila genes that are responsible for apoptosis regulation. However, the underlying molecular mechanisms for apoptosis regulation in lepidopteran insect cells remain poorly understood. In the present study, we demonstrated that the transfection of Bombyx mori BM-N cells with dsRNA against the B. mori cellular iap1 gene (cbm-iap1) induces severe apoptosis that is accompanied by an increase of caspase-3-like protease activity. In these apoptotic cells, the cleaved form of the endogenous initiator caspase Dronc (Bm-Dronc) was detected, indicating that cBm-IAP1 protein depletion by RNAi silencing resulted in the activation of Bm-Dronc. In transient expression assays in BM-N cells, cBm-IAP1 suppressed the apoptosis triggered by Bm-Dronc overexpression and depressed the elevation of caspase-3-like protease activity, but also increased the cleaved form of Bm-Dronc protein. cBm-IAP1 also suppressed the caspase-3-like protease activity stimulated by Bm-caspase-1 overexpression. Co-immunoprecipitation experiments demonstrated that cBm-IAP1 strongly interacts with Bm-Dronc, but only has weak affinity for Bm-caspase-1. Transient expression analyses showed that truncated cBm-IAP1 proteins defective in the BIR1, BIR2 or RING domain were unable to suppress Bm-Dronc-induced apoptosis. In addition, BM-N cells expressing truncated cBm-IAP1 proteins underwent apoptosis, suggesting that intact cBm-IAP1, which has anti-apoptotic activity, was replaced or displaced by the overexpressed truncated cBm-IAP1 proteins, which are incapable of interfering with the apoptotic caspase cascade. Taken together, the present results demonstrate that cBm-IAP1 is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1." @default.
• W2543242644 created "2016-11-04" @default.
• W2543242644 creator A5002436491 @default.
• W2543242644 creator A5008673953 @default.
• W2543242644 creator A5009203389 @default.
• W2543242644 creator A5020918440 @default.
• W2543242644 creator A5040356126 @default.
• W2543242644 creator A5053625402 @default.
• W2543242644 creator A5078373211 @default.
• W2543242644 creator A5087479846 @default.
• W2543242644 date "2016-12-01" @default.
• W2543242644 modified "2023-09-28" @default.
• W2543242644 title "Functional analysis of inhibitor of apoptosis 1 of the silkworm Bombyx mori" @default.
• W2543242644 cites W1530629109 @default.
• W2543242644 cites W1586475872 @default.
• W2543242644 cites W1596498305 @default.
• W2543242644 cites W1825931139 @default.
• W2543242644 cites W1900669615 @default.
• W2543242644 cites W1962024916 @default.
• W2543242644 cites W1970167573 @default.
• W2543242644 cites W1973563597 @default.
• W2543242644 cites W1974146811 @default.
• W2543242644 cites W1976766400 @default.
• W2543242644 cites W1977139249 @default.
• W2543242644 cites W1981994588 @default.
• W2543242644 cites W1982677831 @default.
• W2543242644 cites W1984046437 @default.
• W2543242644 cites W1984229970 @default.
• W2543242644 cites W1990394716 @default.
• W2543242644 cites W1995429659 @default.
• W2543242644 cites W2005568569 @default.
• W2543242644 cites W2008757142 @default.
• W2543242644 cites W2017524293 @default.
• W2543242644 cites W2024864136 @default.
• W2543242644 cites W2026034997 @default.
• W2543242644 cites W2026970528 @default.
• W2543242644 cites W2036454153 @default.
• W2543242644 cites W2040289871 @default.
• W2543242644 cites W2046623597 @default.
• W2543242644 cites W2048540171 @default.
• W2543242644 cites W2049675426 @default.
• W2543242644 cites W2050995906 @default.
• W2543242644 cites W2052062814 @default.
• W2543242644 cites W2052788415 @default.
• W2543242644 cites W2054929638 @default.
• W2543242644 cites W2058101735 @default.
• W2543242644 cites W2060094943 @default.
• W2543242644 cites W2073243869 @default.
• W2543242644 cites W2074180135 @default.
• W2543242644 cites W2076770177 @default.
• W2543242644 cites W2080675930 @default.
• W2543242644 cites W2090369715 @default.
• W2543242644 cites W2093423926 @default.
• W2543242644 cites W2099053209 @default.
• W2543242644 cites W2104467548 @default.
• W2543242644 cites W2105906527 @default.
• W2543242644 cites W2106721770 @default.
• W2543242644 cites W2112582070 @default.
• W2543242644 cites W2118071427 @default.
• W2543242644 cites W2118126255 @default.
• W2543242644 cites W2118732328 @default.
• W2543242644 cites W2135799262 @default.
• W2543242644 cites W2137498548 @default.
• W2543242644 cites W2139108393 @default.
• W2543242644 cites W2142911981 @default.
• W2543242644 cites W2143872403 @default.
• W2543242644 cites W2144217701 @default.
• W2543242644 cites W2144420494 @default.
• W2543242644 cites W2154120432 @default.
• W2543242644 cites W2159728493 @default.
• W2543242644 cites W2160567170 @default.
• W2543242644 cites W2169875163 @default.
• W2543242644 cites W2170247411 @default.
• W2543242644 cites W2318482968 @default.
• W2543242644 cites W4230515018 @default.
• W2543242644 doi "https://doi.org/10.1016/j.ibmb.2016.10.012" @default.
• W2543242644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28327305" @default.
• W2543242644 hasPublicationYear "2016" @default.
• W2543242644 type Work @default.
• W2543242644 sameAs 2543242644 @default.
• W2543242644 citedByCount "18" @default.
• W2543242644 countsByYear W25432426442018 @default.
• W2543242644 countsByYear W25432426442019 @default.
• W2543242644 countsByYear W25432426442020 @default.
• W2543242644 countsByYear W25432426442021 @default.
• W2543242644 countsByYear W25432426442023 @default.
• W2543242644 crossrefType "journal-article" @default.
• W2543242644 hasAuthorship W2543242644A5002436491 @default.
• W2543242644 hasAuthorship W2543242644A5008673953 @default.
• W2543242644 hasAuthorship W2543242644A5009203389 @default.
• W2543242644 hasAuthorship W2543242644A5020918440 @default.
• W2543242644 hasAuthorship W2543242644A5040356126 @default.
• W2543242644 hasAuthorship W2543242644A5053625402 @default.
• W2543242644 hasAuthorship W2543242644A5078373211 @default.
• W2543242644 hasAuthorship W2543242644A5087479846 @default.
• W2543242644 hasConcept C104317684 @default.
• W2543242644 hasConcept C119056186 @default.
• W2543242644 hasConcept C153911025 @default.

• next