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- W2543286693 abstract "Abstract In the idling brain, neuronal circuits often exhibit transitions between periods of sustained firing (UP state) and quiescence (DOWN state). Although these dynamics occur across multiple areas and behavioral conditions, the underlying mechanisms remain unclear. Here we analyze spontaneous population activity from the somatosensory cortex of urethane-anesthetized rats. We find that UP and DOWN periods are variable (i.e. non-rhythmic) and that the population rate shows no significant decay during UP periods. We build a network model of excitatory (E) and inhibitory (I) neurons that exhibits a new bistability between a quiescent state and a balanced state of arbitrarily low rate. Fluctuating inputs trigger state transitions. Adaptation in E cells paradoxically causes a marginal decay of E-rate but a marked decay of I-rate, a signature of balanced bistability that we validate experimentally. Our findings provide evidence of a bistable balanced network that exhibits non-rhythmic state transitions when the brain rests." @default.
- W2543286693 created "2016-11-04" @default.
- W2543286693 creator A5008517726 @default.
- W2543286693 creator A5015767542 @default.
- W2543286693 creator A5047020510 @default.
- W2543286693 creator A5057276527 @default.
- W2543286693 creator A5067209600 @default.
- W2543286693 creator A5070756422 @default.
- W2543286693 date "2016-10-26" @default.
- W2543286693 modified "2023-10-07" @default.
- W2543286693 title "UP-DOWN cortical dynamics reflect state transitions in a bistable balanced network" @default.
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