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- W2543547728 abstract "The pain usually associated with intradermal injection of lidocaine and epinephrine is significantly attenuated by the addition of either sodium bicarbonate or sodium hydroxide to 1% lidocaine with epinephrine. This suggests that sodium bicarbonate attenuates pain by increasing the pH of the anesthetic solution. The clinical effects of a solution of lidocaine (1%) with epinephrine (1:100,000) and sodium bicarbonate (80 meq/L) were assessed after infiltration in skin. Anesthetic stored for 1 week caused nearly equal areas of anesthesia and vasoconstriction as an identical solution prepared on the day of use." @default.
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- W2543547728 date "1990-09-01" @default.
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- W2543547728 title "Neutralized Lidocaine with Epinephrine for Local Anesthesia - II" @default.
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- W2543547728 doi "https://doi.org/10.1111/j.1524-4725.1990.tb01570.x" @default.
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