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- W2543621568 abstract "After being approved by the National Drug Agency in several countries, Radium-223 (Ra-223) is gaining wide acceptance in the treatment of bone metastatic castration resistant prostate cancer. The exact mechanism of action remain unclear: The established model of direct alpha-particle irradiation from the remodelling bone surface, where Ra-223 accumulates, surrounding the tumor foci can explain a lethal effect only on metastatic microdeposits, but not on higher tumor burden. According to the pre-metastatic niche model, it is likely that Ra-223 targets several non-tumoral cell types of the tumor microenvironment involved in the complex mechanism of cancer bone homing and colonization. A deeper insight into this hypothetical mechanism will lead to a more accurate dosimetric approach and to find optimal sequencing and/or combination with the other therapeutic options." @default.
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- W2543621568 date "2016-01-01" @default.
- W2543621568 modified "2023-09-26" @default.
- W2543621568 title "Radium-223 and metastatic castration-resistant prostate cancer: All that glitters is not gold" @default.
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- W2543621568 doi "https://doi.org/10.4329/wjr.v8.i10.816" @default.
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