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• W2543669709 abstract "Background . There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods . A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria were patients who were on adefovir or tenofovir as mono- or add-on therapy with lamivudine (LAM) >1 year. Serum and urine were collected. Fractional excretion of phosphate (FEPO 4 ), uric acid (FEUA), and potassium was calculated. Renal losses were defined based on the criteria: protein (24-hour urine protein >150 mg), glucose (glycosuria with normoglycemia), phosphate (FEPO 4 >18%), uric acid (FEUA >15%), potassium (renal potassium losses with hypokalemia), and bicarbonate (normal gap acidosis). Subclinical and overt proximal RTD were defined when 2 and ≥3 criteria presented. Results . Ninety-two patients were enrolled. The mean duration of nucleotide analogue taking was<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn fontstyle=italic>55.1</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>29.6</mml:mn></mml:math>months. Proximal RTD was found in 24 (26.1%) patients (subclinical 15 (16.3%) and overt 9 (9.8%)). The severity of RTD was associated with the duration of nucleotide analogue (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.01</mml:mn></mml:math>). Conclusions . The prevalence of proximal RTD in CHB patients taking nucleotide analogues was 26%. The severity of RTD was associated with the treatment duration. Comprehensive testing is necessary for early detecting nucleotide analogue-related nephrotoxicity." @default.
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• W2543669709 date "2016-01-01" @default.
• W2543669709 modified "2023-09-25" @default.
• W2543669709 title "Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study" @default.
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• W2543669709 doi "https://doi.org/10.1155/2016/2952635" @default.
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