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- W2543922278 endingPage "10172" @default.
- W2543922278 startingPage "10161" @default.
- W2543922278 abstract "With mounting evidence that nanomaterials can trigger adverse innate immune responses such as complement activation, there is increasing attention to the development of strategies that mask the complement-activating properties of nanomaterials. The current gold standard to reduce complement activation of nanomaterials is the covalent attachment of polymer coatings on nanomaterial surfaces, even though this strategy provides only moderate protection against complement activation. Akin to protein coronas that form on nanomaterial surfaces in physiological fluids, noncovalent strategies based on protein adsorption would offer a simplified, biomimetic approach to mitigate complement activation. Herein, we demonstrate that precoating graphene-based nanomaterials with purified, natural proteins enables regulatory control of nanomaterial-triggered complement activation. When the graphene-based nanomaterials were coated with complement factor H, nearly complete protection (>90% reduction) against complement activation (a stealth effect) was achieved. By contrast, coating the nanomaterials with a passivating layer of bovine or human serum albumins achieved moderate protection (∼40% reduction), whereas immunoglobulin G amplified complement activation by several-fold. Taken together, our results demonstrate that surface-bound factor H, as well as serum albumins, can prevent graphene oxide-triggered complement activation, thereby offering a facile approach to inhibit complement activation completely down to naturally occurring levels." @default.
- W2543922278 created "2016-11-04" @default.
- W2543922278 creator A5003642180 @default.
- W2543922278 creator A5013993870 @default.
- W2543922278 creator A5024485764 @default.
- W2543922278 creator A5041228413 @default.
- W2543922278 creator A5049675779 @default.
- W2543922278 creator A5056204687 @default.
- W2543922278 creator A5066515999 @default.
- W2543922278 creator A5069083707 @default.
- W2543922278 creator A5087948924 @default.
- W2543922278 date "2016-11-07" @default.
- W2543922278 modified "2023-10-17" @default.
- W2543922278 title "Stealth Immune Properties of Graphene Oxide Enabled by Surface-Bound Complement Factor H" @default.
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