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- W2543935919 endingPage "1785" @default.
- W2543935919 startingPage "1785" @default.
- W2543935919 abstract "Alzheimer’s disease (AD) is the most common cause of dementia in the elderly population, currently affecting 46 million people worldwide. Histopathologically, the disease is characterized by the occurrence of extracellular amyloid plaques composed of aggregated amyloid-β (Aβ) peptides and intracellular neurofibrillary tangles containing the microtubule-associated protein tau. Aβ peptides are derived from the sequential processing of the amyloid precursor protein (APP) by enzymes called secretases, which are strongly influenced by the lipid environment. Several vitamins have been reported to be reduced in the plasma/serum of AD-affected individuals indicating they have an impact on AD pathogenesis. In this review we focus on vitamin E and the other lipophilic vitamins A, D, and K, and summarize the current knowledge about their status in AD patients, their impact on cognitive functions and AD risk, as well as their influence on the molecular mechanisms of AD. The vitamins might affect the generation and clearance of Aβ both by direct effects and indirectly by altering the cellular lipid homeostasis. Additionally, vitamins A, D, E, and K are reported to influence further mechanisms discussed to be involved in AD pathogenesis, e.g., Aβ-aggregation, Aβ-induced neurotoxicity, oxidative stress, and inflammatory processes, as summarized in this article." @default.
- W2543935919 created "2016-11-04" @default.
- W2543935919 creator A5015283879 @default.
- W2543935919 creator A5036985947 @default.
- W2543935919 creator A5046904851 @default.
- W2543935919 date "2016-10-26" @default.
- W2543935919 modified "2023-10-16" @default.
- W2543935919 title "The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease" @default.
- W2543935919 cites W1424634560 @default.
- W2543935919 cites W1487935461 @default.
- W2543935919 cites W1490443500 @default.
- W2543935919 cites W1515018114 @default.
- W2543935919 cites W1526586150 @default.
- W2543935919 cites W1551962384 @default.
- W2543935919 cites W1552783278 @default.
- W2543935919 cites W1557365633 @default.
- W2543935919 cites W1559660300 @default.
- W2543935919 cites W1580480113 @default.
- W2543935919 cites W1594975246 @default.
- W2543935919 cites W1611407165 @default.
- W2543935919 cites W1627982367 @default.
- W2543935919 cites W1750300060 @default.
- W2543935919 cites W1822032979 @default.
- W2543935919 cites W1885793991 @default.
- W2543935919 cites W1896341100 @default.
- W2543935919 cites W1896511357 @default.
- W2543935919 cites W1922087192 @default.
- W2543935919 cites W1933934710 @default.
- W2543935919 cites W1941294128 @default.
- W2543935919 cites W1965050626 @default.
- W2543935919 cites W1967205144 @default.
- W2543935919 cites W1968226859 @default.
- W2543935919 cites W1969738113 @default.
- W2543935919 cites W1969968664 @default.
- W2543935919 cites W1973148347 @default.
- W2543935919 cites W1973245527 @default.
- W2543935919 cites W1973932627 @default.
- W2543935919 cites W1974790839 @default.
- W2543935919 cites W1975806945 @default.
- W2543935919 cites W1977007818 @default.
- W2543935919 cites W1979533112 @default.
- W2543935919 cites W1980420209 @default.
- W2543935919 cites W1980808435 @default.
- W2543935919 cites W1984964878 @default.
- W2543935919 cites W1991435932 @default.
- W2543935919 cites W1992045133 @default.
- W2543935919 cites W1993172244 @default.
- W2543935919 cites W1993383247 @default.
- W2543935919 cites W1994221276 @default.
- W2543935919 cites W1994521227 @default.
- W2543935919 cites W1995193554 @default.
- W2543935919 cites W1995582336 @default.
- W2543935919 cites W1997198091 @default.
- W2543935919 cites W1998905522 @default.
- W2543935919 cites W2000631247 @default.
- W2543935919 cites W2004465970 @default.
- W2543935919 cites W2006154113 @default.
- W2543935919 cites W2008275433 @default.
- W2543935919 cites W2009111659 @default.
- W2543935919 cites W2009688542 @default.
- W2543935919 cites W2012227436 @default.
- W2543935919 cites W2012601387 @default.
- W2543935919 cites W2013061431 @default.
- W2543935919 cites W2013074496 @default.
- W2543935919 cites W2013753233 @default.
- W2543935919 cites W2014272598 @default.
- W2543935919 cites W2014886338 @default.
- W2543935919 cites W2015807060 @default.
- W2543935919 cites W2020969115 @default.
- W2543935919 cites W2021041444 @default.
- W2543935919 cites W2021950004 @default.
- W2543935919 cites W2024037661 @default.
- W2543935919 cites W2028301593 @default.
- W2543935919 cites W2032920422 @default.
- W2543935919 cites W2033170953 @default.
- W2543935919 cites W2037231427 @default.
- W2543935919 cites W2039173359 @default.
- W2543935919 cites W2042130020 @default.
- W2543935919 cites W2045267711 @default.
- W2543935919 cites W2046847750 @default.
- W2543935919 cites W2050341478 @default.
- W2543935919 cites W2052084403 @default.
- W2543935919 cites W2053227808 @default.
- W2543935919 cites W2054030934 @default.
- W2543935919 cites W2054159913 @default.
- W2543935919 cites W2055409595 @default.
- W2543935919 cites W2056855059 @default.
- W2543935919 cites W2058145440 @default.
- W2543935919 cites W2058324277 @default.
- W2543935919 cites W2058803950 @default.
- W2543935919 cites W2059215870 @default.
- W2543935919 cites W2060801523 @default.
- W2543935919 cites W2062956001 @default.
- W2543935919 cites W2064032283 @default.
- W2543935919 cites W2065715317 @default.
- W2543935919 cites W2067430815 @default.
- W2543935919 cites W2068019148 @default.
- W2543935919 cites W2070596032 @default.